A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

A Free Radical-Generating System Regulates AβPP Metabolism/Processing: Involvement of the Ubiquitin/Proteasome and Autophagy/Lysosome Pathways

(2018) María Recuero et al.   JOURNAL OF ALZHEIMERS DISEASE

Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

(2017) Lauren S. Whyte et al.   JOURNAL OF NEUROCHEMISTRY

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

(2017) David L. Brody et al.   Alzheimers Research & Therapy

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis

(2016) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

(2016) Stjepko Cermak et al.   PLoS One

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner

(2015) Jun Taneo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Racemization of the Aspartic Acid Residue of Amyloid-β Peptide by a Radical Reaction

(2015) Koharu TAMBO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease

(2014) Kazuma Murakami   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Beyond pathology: APP, brain development and Alzheimer's disease

(2014) Alessia Soldano et al.   CURRENT OPINION IN NEUROBIOLOGY

Simultaneous Determination of Post-Translational Racemization and Isomerization of N-Terminal Amyloid-β in Alzheimer’s Brain Tissues by Covalent Chiral Derivatized Ultraperformance Liquid Chromatography Tandem Mass Spectrometry

(2013) Koichi Inoue et al.   ANALYTICAL CHEMISTRY

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells

(2013) Kristine Porter et al.   Autophagy

CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid

(2013) Kwangmin Cho et al.   NEUROSCIENCE LETTERS

Oxidative Stress Enhances Neurodegeneration Markers Induced by Herpes Simplex Virus Type 1 Infection in Human Neuroblastoma Cells

(2013) Soraya Santana et al.   PLoS One

Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review

(2013) Tetsumori Yamashima   PROGRESS IN NEUROBIOLOGY

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

(2012) Akihiko Nunomura et al.   NEUROTOXICITY RESEARCH

Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C

(2011) Fang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal and Axonal Loss Are Selectively Linked to Fibrillar Amyloid-β within Plaques of the Aged Primate Cerebral Cortex

(2010) Palak Shah et al.   AMERICAN JOURNAL OF PATHOLOGY

A free radical-generating system regulates APP metabolism/processing

(2010) María Recuero et al.   FEBS LETTERS

Protein homeostasis and aging in neurodegeneration

(2010) Peter M. Douglas et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

A free radical-generating system induces the cholesterol biosynthesis pathway: a role in Alzheimer's disease

(2009) María Recuero et al.   AGING CELL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY