rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures

(2017) Cara L Croft et al.   Cell Death & Disease

Oxytocin stimulates hippocampal neurogenesis via oxytocin receptor expressed in CA3 pyramidal neurons

(2017) Yu-Ting Lin et al.   Nature Communications

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines

(2017) Amanda L. Woerman et al.   JAMA Neurology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

(2017) Kevin H. Strang et al.   Acta Neuropathologica Communications

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease

(2017) Cara L. Croft et al.   Scientific Reports

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges

(2016) Mansi R. Khanna et al.   Alzheimers & Dementia

Tau: From research to clinical development

(2016) David M. Holtzman et al.   Alzheimers & Dementia

Microglia in Alzheimer's Disease: The Good, the Bad and the Ugly

(2016) Dario Tejera et al.   Current Alzheimer Research

Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

(2016) Sumihiro Maeda et al.   EMBO REPORTS

The Tau/A152T mutation, a risk factor for frontotemporal‐spectrum disorders, leads to NR2B receptor‐mediated excitotoxicity

(2016) Jochen Martin Decker et al.   EMBO REPORTS

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

(2016) Ghulam Jeelani Pir et al.   Molecular Neurodegeneration

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

(2016) Astrid Sydow et al.   Acta Neuropathologica Communications

IFN-γ promotes τ phosphorylation without affecting mature tangles

(2015) Andrew Li et al.   FASEB JOURNAL

Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10 + 16 splice-site mutation in MAPT

(2015) Teresa Sposito et al.   HUMAN MOLECULAR GENETICS

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

(2015) Carolina Ceballos-Diaz et al.   Molecular Neurodegeneration

Organotypic brain slice cultures: A review

(2015) C. Humpel   NEUROSCIENCE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Alpha-synuclein biology in Lewy body diseases

(2014) Woojin Scott Kim et al.   Alzheimers Research & Therapy

Open questions for Alzheimer’s disease immunotherapy

(2014) Todd E Golde   Alzheimers Research & Therapy

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Thinking laterally about neurodegenerative proteinopathies

(2013) Todd E. Golde et al.   JOURNAL OF CLINICAL INVESTIGATION

AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans

(2013) Biljana Georgievska et al.   JOURNAL OF NEUROCHEMISTRY

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

(2013) Amanda N Sacino et al.   Molecular Neurodegeneration

Anti-Tau Antibodies: Hitting the Target

(2013) Todd E. Golde et al.   NEURON

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic Mouse Models of Tauopathy in Drug Discovery

(2012) W. Noble et al.   CNS & Neurological Disorders-Drug Targets

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis

(2012) Christophe Verbeeck et al.   Molecular Neurodegeneration

Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors

(2012) Lars Messing et al.   NEUROBIOLOGY OF AGING

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study

(2011) Melissa E Murray et al.   LANCET NEUROLOGY

Tau cleavage and tau aggregation in neurodegenerative disease: Figure 1

(2010) Diane P. Hanger et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

From tau phosphorylation to tau aggregation: what about neuronal death?: Figure 1

(2010) Luc Buée et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IFN-  Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid   Precursor Protein Transgenic Mice

(2010) P. Chakrabarty et al.   JOURNAL OF IMMUNOLOGY

Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS

(2009) Laura Lossi et al.   PROGRESS IN NEUROBIOLOGY

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau

(2007) Roland Brandt et al.   NEUROBIOLOGY OF AGING