Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

(2016) Sachin Suresh Tiwari et al.   BRAIN

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

(2016) Marie K. Bondulich et al.   BRAIN

Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model

(2016) Renata Novotny et al.   JOURNAL OF NEUROSCIENCE

Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice

(2016) Claire S. Harwell et al.   Molecular Neurodegeneration

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

(2016) Ksenia Kurbatskaya et al.   Acta Neuropathologica Communications

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Jada Lewis et al.   ACTA NEUROPATHOLOGICA

mTor mediates tau localization and secretion: Implication for Alzheimer's disease

(2015) Zhi Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

No full admission for tau to the exclusive prion club yet

(2015) J. C. Polanco et al.   EMBO JOURNAL

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death

(2015) D. Kanmert et al.   JOURNAL OF NEUROSCIENCE

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: a mechanistic distinct event from other neurodegenerative processes

(2015) Nataliya Golovyashkina et al.   Molecular Neurodegeneration

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Invited review: Prion-like transmission and spreading of tau pathology

(2015) Florence Clavaguera et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

(2015) Christian Humpel   Frontiers in Aging Neuroscience

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

The physiology and pathology of microtubule-associated protein tau

(2014) Jian-Zhi Wang et al.   Essays in Biochemistry

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein

(2014) Simon Dujardin et al.   PLoS One

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

(2013) C Tackenberg et al.   Cell Death & Disease

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

Tau Overexpression Results in Its Secretion via Membrane Vesicles

(2012) Diana Simón et al.   Neurodegenerative Diseases

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion

(2012) Vanessa Plouffe et al.   PLoS One

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice—A Model for Tauopathy Studies

(2012) Agneta Mewes et al.   PLoS One

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Attention in the 3xTgAD Mouse Model of Alzheimer's Disease: Rescue by Donepezil (Aricept)

(2011) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice

(2011) S. Sakura Minami et al.   NEUROBIOLOGY OF AGING

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

(2008) A. Gómez-Ramos et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Decreased Presence of Perforated Synapses in a Triple-Transgenic Mouse Model of Alzheimer's Disease

(2008) Carlo Bertoni-Freddari et al.   REJUVENATION RESEARCH