Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice

Pathogenic Ubqln2 gains toxic properties to induce neuron death

(2014) Qinxue Wu et al.   ACTA NEUROPATHOLOGICA

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

UBQLN2mutation causing heterogeneous X-linked dominant neurodegeneration

(2014) Akl C. Fahed et al.   ANNALS OF NEUROLOGY

The ubiquilin gene family: evolutionary patterns and functional insights

(2014) Ignacio Marín   BMC EVOLUTIONARY BIOLOGY

Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutantUBQLN2

(2014) George H. Gorrie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation

(2013) Yuxing Xia et al.   JOURNAL OF NEUROCHEMISTRY

Conformational templating of α-synuclein aggregates in neuronal-glial cultures

(2013) Amanda N Sacino et al.   Molecular Neurodegeneration

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

(2013) Paramita Chakrabarty et al.   PLoS One

Ubiquilin 2 Is Not Associated with Tau Pathology

(2013) Anna Nölle et al.   PLoS One

Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype

(2012) Matthis Synofzik et al.   NEUROBIOLOGY OF AGING

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Making Connections: Pathology and Genetics Link Amyotrophic Lateral Sclerosis with Frontotemporal Lobe Dementia

(2011) Faisal Fecto et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD

(2009) Precious J. Lim et al.   JOURNAL OF CELL BIOLOGY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Characterization of antibodies that selectively detect α-synuclein in pathological inclusions

(2008) Elisa A. Waxman et al.   ACTA NEUROPATHOLOGICA

Herp enhances ER-associated protein degradation by recruiting ubiquilins

(2008) Tae-Yeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BRI2 (ITM2b) Inhibits A  Deposition In Vivo

(2008) J. Kim et al.   JOURNAL OF NEUROSCIENCE