The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity

Collagen 18 and agrin are secreted by neural crest cells to remodel their microenvironment and regulate their migration during enteric nervous system development

(2018) Nandor Nagy et al.   DEVELOPMENT

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

(2018) Aurélie S. Cazet et al.   Nature Communications

Role of the ECM in notochord formation, function and disease

(2017) Valeria Trapani et al.   JOURNAL OF CELL SCIENCE

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Connective tissue growth factor promotes temozolomide resistance in glioblastoma through TGF-β1-dependent activation of Smad/ERK signaling

(2017) Huijun Zeng et al.   Cell Death & Disease

Human renal adipose tissue induces the invasion and progression of renal cell carcinoma

(2017) Fiorella Campo-Verde-Arbocco et al.   Oncotarget

The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance

(2017) Minh Ngoc Duong et al.   Oncotarget

Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components

(2017) Laween Meran et al.   Stem Cells International

Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

(2017) Amy Dwyer et al.   Cancers

Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells

(2017) Marcello Monti et al.   PLoS One

Phenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironment

(2016) Genichiro Ishii et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility

(2016) Francois Bordeleau et al.   JOURNAL OF BIOMECHANICS

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil extracellular traps: protagonists of cancer progression?

(2016) L Erpenbeck et al.   ONCOGENE

Inhibition of Focal Adhesion Kinase Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal

(2016) Luis G. Villa-Diaz et al.   STEM CELLS

Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy

(2016) J. Incio et al.   Cancer Discovery

Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1β dependent upregulation ofMYO3Agene in breast cancer cells

(2016) Khemraj Singh Baghel et al.   OncoImmunology

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

α6β1- and αV-integrins are required for long-term self-renewal of murine embryonic stem cells in the absence of LIF

(2015) Sandhanakrishnan Cattavarayane et al.   BMC CELL BIOLOGY

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway

(2015) Wei Xu et al.   CANCER LETTERS

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Microenvironment, tumor cell plasticity, and cancer

(2015) Eva Faurobert et al.   CURRENT OPINION IN ONCOLOGY

A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis

(2015) Jasreen Kular et al.   DEVELOPMENTAL CELL

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

(2015) Sarah T. Boyle et al.   Molecular Cancer

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies

(2015) C Raggi et al.   ONCOGENE

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis

(2015) Bo Ri Seo et al.   Science Translational Medicine

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

(2015) James W. Clancy et al.   Nature Communications

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics

(2015) Joanna M. Woodcock et al.   Oncotarget

Neutrophils Increase Oral Squamous Cell Carcinoma Invasion through an Invadopodia-Dependent Pathway

(2015) J. E. Glogauer et al.   Cancer Immunology Research

Cancer Microenvironment and Inflammation: Role of Hyaluronan

(2015) Dragana Nikitovic et al.   Frontiers in Immunology

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

Lysyl Oxidase Contributes to Mechanotransduction-Mediated Regulation of Transforming Growth Factor-β Signaling in Breast Cancer Cells

(2015) Molly A. Taylor et al.   NEOPLASIA

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma

(2014) Qing-Min Fan et al.   CANCER LETTERS

A Noncanonical Frizzled2 Pathway Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Taranjit S. Gujral et al.   CELL

Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells

(2014) I Ischenko et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil extracellular traps in cancer progression

(2014) Jonathan Cools-Lartigue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

(2014) M. Diepenbruck et al.   JOURNAL OF CELL SCIENCE

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

(2014) Masayuki Shimoda et al.   NATURE CELL BIOLOGY

Obesity and cancer—mechanisms underlying tumour progression and recurrence

(2014) Jiyoung Park et al.   Nature Reviews Endocrinology

Live Imaging and Gene Expression Analysis in Zebrafish Identifies a Link between Neutrophils and Epithelial to Mesenchymal Transition

(2014) Christina M. Freisinger et al.   PLoS One

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis

(2014) Hon S. Leong et al.   Cell Reports

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

Wound healing and the role of fibroblasts

(2014) Bainbridge P.   Journal of Wound Care

Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment

(2014) Elena I. Deryugina et al.   NEOPLASIA

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

(2013) T. R. Cox et al.   CANCER RESEARCH

Connective Tissue Growth Factor Activates Pluripotency Genes and Mesenchymal–Epithelial Transition in Head and Neck Cancer Cells

(2013) Cheng-Chi Chang et al.   CANCER RESEARCH

Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

(2013) D. M. Gilkes et al.   CANCER RESEARCH

Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer

(2013) L. Bochet et al.   CANCER RESEARCH

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

(2013) Tania Fiaschi et al.   CELL CYCLE

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

M2-polarized tumor-associated macrophages promoted epithelial–mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway

(2013) Chao-Ying Liu et al.   LABORATORY INVESTIGATION

Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase

(2013) Lei Gong et al.   Molecular Cancer

Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

(2013) Daniele M. Gilkes et al.   MOLECULAR CANCER RESEARCH

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

CTGF is a therapeutic target for metastatic melanoma

(2013) E C Finger et al.   ONCOGENE

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

(2013) Chunmei Yang et al.   PLoS One

Adipogenesis: From Stem Cell to Adipocyte

(2012) Qi Qun Tang et al.   Annual Review of Biochemistry

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

(2012) Anne-Katrine Bonde et al.   BMC CANCER

Tumor Cell-educated Periprostatic Adipose Tissue Acquires an Aggressive Cancer-promoting Secretory Profile

(2012) Ricardo J.T. Ribeiro et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase

(2012) Thomas Große-Steffen et al.   Clinical & Developmental Immunology

Mature breast adipocytes promote breast cancer cell motility

(2012) Jennifer C. Carter et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

TGF-β control of stem cell differentiation genes

(2012) Joan Massagué et al.   FEBS LETTERS

Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma

(2012) Shao-Lai Zhou et al.   HEPATOLOGY

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

Adipocyte-derived endotrophin promotes malignant tumor progression

(2012) Jiyoung Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

Vascular endothelial growth factor-induced skin carcinogenesis depends on recruitment and alternative activation of macrophages

(2012) Nina Linde et al.   JOURNAL OF PATHOLOGY

Macrophages Promote Fibroblast Growth Factor Receptor-Driven Tumor Cell Migration and Invasion in a Cxcr2-Dependent Manner

(2012) L. R. Bohrer et al.   MOLECULAR CANCER RESEARCH

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

(2012) C. P. El-Haibi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking away: matrix remodeling from the leading edge

(2012) Mark A. McNiven   TRENDS IN CELL BIOLOGY

Microenvironmental Regulation of Cancer Stem Cell Phenotypes

(2012) Daniela F. Quail et al.   Current Stem Cell Research & Therapy

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

(2011) Takuya Shirakihara et al.   EMBO JOURNAL

Variation of tumor-infiltrating lymphocytes in human cancers: controversy on clinical significance

(2011) Tetsuro Sasada et al.   Immunotherapy

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I

(2011) C Popov et al.   Cell Death & Disease

Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma

(2011) Manuela Liguori et al.   Cancers

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

(2010) Daiko Wakita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis

(2010) Andrew Martins et al.   IUBMB LIFE

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Matrix Metalloproteinase-Induced Epithelial-Mesenchymal Transition in Breast Cancer

(2010) Evette S. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

(2010) A McGarry Houghton et al.   NATURE MEDICINE

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

(2009) Shuh Narumiya et al.   CANCER AND METASTASIS REVIEWS

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Hematopoietic stem cell origin of adipocytes

(2009) Yasuhiko Sera et al.   EXPERIMENTAL HEMATOLOGY

Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions

(2009) C. Albiges-Rizo et al.   JOURNAL OF CELL SCIENCE

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

(2009) I. Ota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metastatic Cancer Cell

(2008) Marina Bacac et al.   Annual Review of Pathology-Mechanisms of Disease

Molecular signatures suggest a major role for stromal cells in development of invasive breast cancer

(2008) Theresa Casey et al.   BREAST CANCER RESEARCH AND TREATMENT

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Identification of White Adipocyte Progenitor Cells In Vivo

(2008) Matthew S. Rodeheffer et al.   CELL

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model

(2008) Stephanie Alexander et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Characterization of Transplanted Green Fluorescent Protein+Bone Marrow Cells into Adipose Tissue

(2007) Koji Tomiyama et al.   STEM CELLS