期刊
IUBMB LIFE
卷 62, 期 8, 页码 611-617出版社
WILEY
DOI: 10.1002/iub.361
关键词
granulocyte colony-stimulating factor; immunomodulation; intestine; inflammatory bowel disease
资金
- Natural Sciences & engineering research Council of Canada [312482-2008]
- NIH [AI41637, AI68896]
The three colony-stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte colony-stimulating factor (G-CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM-CSF and M-CSF, G-CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G-CSF, endogenous G-CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G-CSF in immunomodulation and intestinal immune homeostasis. (c) 2010 IUBMB IUBMB Life, 62(8): 611-617, 2010
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