Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

A macrophage relay for long-distance signaling during postembryonic tissue remodeling

(2017) Dae Seok Eom et al.   SCIENCE

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

(2016) Mari Tada et al.   ANNALS OF NEUROLOGY

Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration

(2016) Amy R. Dwyer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The development and maintenance of resident macrophages

(2016) Elisa Gomez Perdiguero et al.   NATURE IMMUNOLOGY

Tissue biology perspective on macrophages

(2016) Yasutaka Okabe et al.   NATURE IMMUNOLOGY

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics

(2016) Carmen Stabile et al.   NEUROLOGICAL SCIENCES

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

CSF-1/CSF-1R targeting agents in clinical development for cancer therapy

(2015) Carola H Ries et al.   CURRENT OPINION IN PHARMACOLOGY

Molecules in medicine mini-review: isoforms of PI3K in biology and disease

(2015) Bart Vanhaesebroeck et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

(2015) Jason H. Stafford et al.   NEURO-ONCOLOGY

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

(2015) Violeta Chitu et al.   NEUROBIOLOGY OF DISEASE

Alternatively activated macrophages are associated with metastasis and poor prognosis in prostate adenocarcinoma

(2015) WENXUE HU et al.   Oncology Letters

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Two-dimensional motility of a macrophage cell line on microcontact-printed fibronectin

(2014) Laurel E. Hind et al.   Cytoskeleton

Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma

(2014) Kirsten Kübler et al.   GYNECOLOGIC ONCOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Macrophages, Immunity, and Metabolic Disease

(2014) Joanne C. McNelis et al.   IMMUNITY

Origin, development, and homeostasis of tissue-resident macrophages

(2014) Malay Haldar et al.   IMMUNOLOGICAL REVIEWS

CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland

(2014) Amy Renee Sullivan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Macrophages migrate in an activation-dependent manner to chemokines involved in neuroinflammation

(2014) Daphne YS Vogel et al.   Journal of Neuroinflammation

Dissecting motility signaling through activation of specific Src-effector complexes

(2014) Andrei V Karginov et al.   Nature Chemical Biology

Idelalisib — A PI3Kδ Inhibitor for B-Cell Cancers

(2014) David A. Fruman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Promotion of Breast Cancer Metastasis Caused by Inhibition of CSF-1R/CSF-1 Signaling Is Blocked by Targeting the G-CSF Receptor

(2014) A. Swierczak et al.   Cancer Immunology Research

CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+T cells

(2014) Debbie C Strachan et al.   OncoImmunology

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Main Histologic Types of Non–Small-Cell Lung Cancer Differ in Expression of Prognosis-related Genes

(2013) Marcin Skrzypski et al.   Clinical Lung Cancer

Specific inhibition of PI3K p110δ inhibits CSF-1-induced macrophage spreading and invasive capacity

(2013) Kellie A. Mouchemore et al.   FEBS Journal

IL-34 and CSF-1: similarities and differences

(2013) Yuko Nakamichi et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS

(2013) T. Konno et al.   NEUROLOGY

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

(2013) Y. Saito et al.   Science Translational Medicine

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head

(2012) Kiyoshi Yoshikawa et al.   CANCER SCIENCE

CSF-1 signaling in macrophages: pleiotrophy through phosphotyrosine-based signaling pathways

(2012) Kellie A. Mouchemore et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Macrophage Proliferation Is Regulated through CSF-1 Receptor Tyrosines 544, 559, and 807

(2012) Wenfeng Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Managing Macrophages in Rheumatoid Arthritis by Reform or Removal

(2012) Jun Li et al.   Current Rheumatology Reports

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Phosphorylation of CSF-1R Y721 mediates its association with PI3K to regulate macrophage motility and enhancement of tumor cell invasion

(2011) N. G. Sampaio et al.   JOURNAL OF CELL SCIENCE

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer

(2011) E. T. Roussos et al.   JOURNAL OF CELL SCIENCE

The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells

(2011) R. Guiet et al.   JOURNAL OF IMMUNOLOGY

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of TH2 Inflammation

(2011) S. J. Jenkins et al.   SCIENCE

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration

(2011) James A. Stefater et al.   TRENDS IN MOLECULAR MEDICINE

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Mechanism of CSF-1-induced Wiskott-Aldrich Syndrome Protein Activationin Vivo

(2009) Michael Cammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Src in Solid Tumors

(2009) D. L. Wheeler et al.   ONCOLOGIST

The diverse functions of Src family kinases in macrophages

(2008) Clare et al.   Frontiers in Bioscience-Landmark

The regulation of cell motility and chemotaxis by phospholipid signaling

(2008) V. Kolsch et al.   JOURNAL OF CELL SCIENCE

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages

(2008) E. A. Papakonstanti et al.   JOURNAL OF CELL SCIENCE

CSF-1 receptor structure/function in MacCsf1r-/- macrophages: regulation of proliferation, differentiation, and morphology

(2008) Wenfeng Yu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE