Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

SIRT1 promotes proliferation, migration, and invasion of breast cancer cell line MCF-7 by upregulating DNA polymerase delta1 (POLD1)

(2018) Yifang Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT1 and microRNAs: The role in breast, lung and prostate cancers

(2018) Hedyieh Karbasforooshan et al.   EXPERIMENTAL CELL RESEARCH

Small Molecules as SIRT Modulators

(2018) Xinfa Bai et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1

(2018) Zhaowei Xu et al.   Cell Death & Disease

SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancer

(2018) Khaldoun Rifaï et al.   Oncotarget

SIRT1 promotes formation of breast cancer through modulating Akt activity

(2018) Xiaoxia Jin et al.   Journal of Cancer

A SIRT1-centered circuitry regulates breast cancer stemness and metastasis

(2018) Lei Shi et al.   ONCOGENE

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

(2018) Félix A. Urra et al.   Scientific Reports

MicroRNA-22 inhibits cell growth and metastasis in breast cancer via targeting of SIRT1

(2017) Quanqing Zou et al.   Experimental and Therapeutic Medicine

Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer

(2017) Khaldoun Rifaï et al.   Oncotarget

Brachyury promotes tamoxifen resistance in breast cancer by targeting SIRT1

(2016) Kaichun Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Mesenchymal stem cells with Sirt1 overexpression suppress breast tumor growth via chemokine-dependent natural killer cells recruitment

(2016) Yang Yu et al.   Scientific Reports

The journey of resveratrol from yeast to human

(2016) Silvie Timmers et al.   Aging-US

BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

(2016) Wenwen Zhang et al.   Scientific Reports

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer

(2015) Soo Young Chung et al.   CLINICAL & EXPERIMENTAL METASTASIS

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

(2015) Junhu Wan et al.   NUCLEIC ACIDS RESEARCH

SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer

(2015) Min-Sun Jin et al.   TUMOR BIOLOGY

SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer

(2015) M F Santolla et al.   Cell Death & Disease

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

(2015) Wei Ma et al.   Oncotarget

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells

(2015) Yong Weon Yi et al.   Oncotarget

Sirtuin modulators: an updated patent review (2012 – 2014)

(2014) Paolo Mellini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity

(2014) Laia Bosch-Presegué et al.   FEBS Journal

Sirtuin inhibitors as anticancer agents

(2014) Jing Hu et al.   Future Medicinal Chemistry

Anticancer Agents Targeted to Sirtuins

(2014) Tomohiro Kozako et al.   MOLECULES

Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities

(2013) Yeong Keng Yoon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

(2013) Paolo Mellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT1-Mediated FoxO1 Deacetylation Is Essential for Multidrug Resistance-Associated Protein 2 Expression in Tamoxifen-Resistant Breast Cancer Cells

(2013) Hoo-Kyun Choi et al.   MOLECULAR PHARMACEUTICS

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies

(2012) Mallika Alvala et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1

(2012) Laisheng Li et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

(2012) JING WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells

(2012) Robert L Moore et al.   JOURNAL OF ENDOCRINOLOGY

Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells

(2012) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer

(2012) Minqing Wu et al.   MEDICAL ONCOLOGY

SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60

(2012) L. Peng et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sirtuins, Metabolism, and Cancer

(2012) Barbara Martinez-Pastor et al.   Frontiers in Pharmacology

SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor   in Breast Cancer

(2011) S. Elangovan et al.   CANCER RESEARCH

miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells

(2011) Gabriel Eades et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities

(2011) L. Peng et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy

(2011) Eun Ji Yu et al.   NUCLEIC ACIDS RESEARCH

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

(2011) A. Menssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

(2011) Glenn M. Marshall et al.   PLoS Genetics

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Balance between SIRT1 and DBC1 expression is lost in breast cancer

(2010) Ji-Youn Sung et al.   CANCER SCIENCE

Role of SIRT1 in homologous recombination

(2010) Miriam Uhl et al.   DNA REPAIR

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

(2010) Limin Han et al.   NUCLEIC ACIDS RESEARCH

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

(2010) M. Ming et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling

(2009) Y. Yao et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

The Sirtuin family: therapeutic targets to treat diseases of aging

(2008) Jill C Milne et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis

(2008) Rui-Hong Wang et al.   MOLECULAR CELL

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Deacetylation of cortactin by SIRT1 promotes cell migration

(2008) Y Zhang et al.   ONCOGENE

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA