The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

(2011) Uffe H Olesen et al.   BMC CANCER

Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

(2011) Shin-ichiro Imai   FEBS LETTERS

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Loss of a single Hic1 allele accelerates polyp formation in ApcΔ716 mice

(2011) H P Mohammad et al.   ONCOGENE

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells

(2010) Ja-Eun Kim et al.   CELL CYCLE

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1

(2010) Claudia C. S. Chini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice

(2010) Carlos Escande et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation

(2010) Clare C. Davies et al.   NATURE CELL BIOLOGY

Transcriptional regulation of BRCA1 expression by a metabolic switch

(2010) Li-Jun Di et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

(2009) Tong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer

(2009) T. Liu et al.   CANCER RESEARCH

Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases

(2009) Shin-ichiro Imai   CURRENT PHARMACEUTICAL DESIGN

SIRT1 markedly extends replicative lifespan if the NAD+salvage pathway is enhanced

(2009) Cynthia Ho et al.   FEBS LETTERS

Inhibition of SUV39H1 Methyltransferase Activity by DBC1

(2009) Zhenyu Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

(2009) Jian Yuan et al.   JOURNAL OF CELL BIOLOGY

SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

(2009) S. B. Rajamohan et al.   MOLECULAR AND CELLULAR BIOLOGY

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

(2009) Stefano Campaner et al.   NATURE CELL BIOLOGY

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

(2008) Jing Huang et al.   PLoS One

AP4 encodes a c-MYC-inducible repressor of p21

(2008) P. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA