Inflammation: Bridging Age, Menopause and APOEε4 Genotype to Alzheimer’s Disease

A tale of two diseases: Aging HIV patients inspire a closer look at Alzheimer's disease

(2018) Shraddha Chakradhar   NATURE MEDICINE

Age at menopause and lifetime cognition

(2018) Diana Kuh et al.   NEUROLOGY

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

(2018) Angela Marie Floden et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial Markers are Elevated in the Prodromal Phase of Alzheimer's Disease and Vascular Dementia

(2018) Bob Olsson et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Molecular Changes in Alzheimer Disease: Can We Catch the Disease in its Presymptomatic Phase?

(2018) Kerstin T.S. Wirz et al.   JOURNAL OF ALZHEIMERS DISEASE

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Associations between specific autoimmune diseases and subsequent dementia: retrospective record-linkage cohort study, UK

(2017) Clare J Wotton et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Sex differences in Alzheimer risk

(2017) Lisa Mosconi et al.   NEUROLOGY

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease

(2017) Scott C. Neu et al.   JAMA Neurology

GM-CSF Upregulated in Rheumatoid Arthritis Reverses Cognitive Impairment and Amyloidosis in Alzheimer Mice

(2017) Tim D. Boyd et al.   JOURNAL OF ALZHEIMERS DISEASE

Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery

(2017) Lisa Mosconi et al.   PLoS One

Hormone therapy at early post-menopause increases cognitive control-related prefrontal activity

(2017) Romuald Girard et al.   Scientific Reports

Rheumatoid arthritis and risk for Alzheimer’s disease: a systematic review and meta-analysis and a Mendelian Randomization study

(2017) Stefania Policicchio et al.   Scientific Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis

(2016) Richard C. Chou et al.   CNS DRUGS

Age-related myelin degradation burdens the clearance function of microglia during aging

(2016) Shima Safaiyan et al.   NATURE NEUROSCIENCE

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases

(2016) Deena Khan et al.   Frontiers in Immunology

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

(2015) Guilherme Cerutti Muller et al.   CELLULAR IMMUNOLOGY

Hippocampal Gene Expression Is Highly Responsive to Estradiol Replacement in Middle-Aged Female Rats

(2015) Miklós Sárvári et al.   ENDOCRINOLOGY

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

(2015) Jun Suenaga et al.   EXPERIMENTAL NEUROLOGY

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

Aging-like changes in the transcriptome of irradiated microglia

(2015) Matthew D. Li et al.   GLIA

APOEPolymorphism Is Associated with C-reactive Protein Levels but Not with White Blood Cell Count: Dong-gu Study and Namwon Study

(2015) Yong-Woon Yun et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

(2015) Leon M. Tai et al.   JOURNAL OF NEUROCHEMISTRY

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

(2015) Clare H Latta et al.   Journal of Neuroinflammation

Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway

(2015) Yasuhiro Ishihara et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inflammasomes are neuroprotective targets for sex steroids

(2015) Alexander Slowik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Perimenopause as a neurological transition state

(2015) Roberta D. Brinton et al.   Nature Reviews Endocrinology

Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype

(2015) Asif Manzoor Khan et al.   NEUROBIOLOGY OF AGING

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

(2015) Fei Yin et al.   NEUROBIOLOGY OF AGING

Age- and location-related changes in microglial function

(2015) Rodney M. Ritzel et al.   NEUROBIOLOGY OF AGING

Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia

(2015) Kumar B. Rajan et al.   NEUROLOGY

Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

(2015) C.H. Latta et al.   NEUROSCIENCE

Hypothalamic microinflammation: a common basis of metabolic syndrome and aging

(2015) Yizhe Tang et al.   TRENDS IN NEUROSCIENCES

Impact of age-related neuroglial cell responses on hippocampal deterioration

(2015) Joseph O. Ojo et al.   Frontiers in Aging Neuroscience

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease

(2015) Lauren P. Klosinski et al.   EBioMedicine

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Critical window hypothesis of hormone therapy and cognition

(2015) Pauline M. Maki   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats

(2014) Roman A. Kireev et al.   AGE

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Human CNS immune senescence and neurodegeneration

(2014) Wolfgang J Streit et al.   CURRENT OPINION IN IMMUNOLOGY

Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microgliain vitro

(2014) Sandra D. Mulder et al.   GLIA

APOε4 is associated with enhanced in vivo innate immune responses in human subjects

(2014) Stephen C. Gale et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetically predicted 17β-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study

(2014) J Zhao et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators

(2014) Estefania Acaz-Fonseca et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer’s disease

(2014) Ann Brinkmalm et al.   Molecular Neurodegeneration

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Trajectories of inflammatory markers and cognitive decline over 10 years

(2014) Andrea L. Metti et al.   NEUROBIOLOGY OF AGING

APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD

(2014) Emily N. Manning et al.   PLoS One

Interleukin-1 deficiency prolongs ovarian lifespan in mice

(2014) S. Uri-Belapolsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human side of microglia

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

Apolipoprotein E gene polymorphism and Alzheimer's disease in Chinese population: a meta-analysis

(2014) Mengying Liu et al.   Scientific Reports

Women with the Alzheimer’s risk marker ApoE4 lose Aβ-specific CD4+ T cells 10–20 years before men

(2014) A N Begum et al.   Translational Psychiatry

C-reactive protein, APOE genotype and longitudinal cognitive change in an older population

(2013) T. A. S. Lima et al.   AGE AND AGEING

Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2013)   Alzheimers & Dementia

Higher Rates of Decline for Women andApolipoprotein Eε4 Carriers

(2013) D. Holland et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

Age-related autoimmunity

(2013) Zahava Vadasz et al.   BMC Medicine

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

(2013) Leo Ungar et al.   Brain Imaging and Behavior

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

CD36: linking lipids to the NLRP3 inflammasome, atherogenesis and atherothrombosis

(2013) Cécile Oury   Cellular & Molecular Immunology

Autoimmune diseases and reproductive aging

(2013) Riley Bove   CLINICAL IMMUNOLOGY

Estrogen: A master regulator of bioenergetic systems in the brain and body

(2013) Jamaica R. Rettberg et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS

(2013) FANG XIE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulation of Hypoxia-Induced Inflammatory Responses and M1-M2 Phenotype Switch of Primary Rat Microglia by Sex Steroids

(2013) Pardes Habib et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

(2013) Shan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

(2013) Jessica M. Crain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

(2013) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

(2013) R. Bove et al.   NEUROLOGY

Distinct activation profiles in microglia of different ages: A systematic study in isolated embryonic to aged microglial cultures

(2013) A.Y. Lai et al.   NEUROSCIENCE

Accelerated Cell Aging in Female APOE-ε4 Carriers: Implications for Hormone Therapy Use

(2013) Emily G. Jacobs et al.   PLoS One

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention

(2013) Fan Ding et al.   PLoS One

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

(2013) V. Hugh Perry et al.   Seminars in Immunopathology

Brain injury, neuroinflammation and Alzheimer's disease

(2013) Joshua J. Breunig et al.   Frontiers in Aging Neuroscience

Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk

(2012) Zeynep Gungor et al.   ATHEROSCLEROSIS

Relationship between baseline brain metabolism measured using [18F]FDG PET and memory and executive function in prodromal and early Alzheimer’s disease

(2012) Christian Habeck et al.   Brain Imaging and Behavior

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Does a Pro-Inflammatory Process Precede Alzheimers Disease and Mild Cognitive Impairment?

(2012) M. T. Ferretti et al.   Current Alzheimer Research

Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?

(2012) Vishwa Deep Dixit   DIABETES

A Lack of Ovarian Function Increases Neuroinflammation in Aged Mice

(2012) Valeria Benedusi et al.   ENDOCRINOLOGY

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

(2012) James G. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation

(2012) Lance A. Johnson et al.   JOURNAL OF LIPID RESEARCH

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

(2012) Dimitrije Krstic et al.   Journal of Neuroinflammation

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes

(2012) Miklós Sárvári et al.   Journal of Neuroinflammation

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis

(2012) M. Tutuncu et al.   Multiple Sclerosis Journal

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Innate Immunity and the Etiology of Late-Onset Alzheimer’s Disease

(2012) Piet Eikelenboom et al.   Neurodegenerative Diseases

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Cognitive Decline in Prodromal Alzheimer Disease and Mild Cognitive Impairment

(2011) Robert S. Wilson et al.   ARCHIVES OF NEUROLOGY

Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages

(2011) Daniel Baitsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidation-Specific Epitopes Are Danger-Associated Molecular Patterns Recognized by Pattern Recognition Receptors of Innate Immunity

(2011) Yury I. Miller et al.   CIRCULATION RESEARCH

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A

(2011) D. J. Christensen et al.   JOURNAL OF IMMUNOLOGY

Selective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells

(2011) M. A. Arevalo et al.   JOURNAL OF NEUROENDOCRINOLOGY

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

(2011) Heather D VanGuilder et al.   Journal of Neuroinflammation

Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats

(2011) Miklós Sárvári et al.   Journal of Neuroinflammation

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-  Expression for Microglial A  Phagocytosis

(2011) D. Terwel et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E Gene Polymorphisms Are Strong Predictors of Inflammation and Dyslipidemia in Rheumatoid Arthritis

(2011) T. E. TOMS et al.   JOURNAL OF RHEUMATOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Impact of apolipoprotein E ε4 and HIV on cognition and brain atrophy: Antagonistic pleiotropy and premature brain aging

(2011) L. Chang et al.   NEUROIMAGE

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of human Toll-like receptor function in aging

(2010) Albert C. Shaw et al.   AGEING RESEARCH REVIEWS

Age-related alterations in the dynamic behavior of microglia

(2010) Mausam R. Damani et al.   AGING CELL

Worldwide allele frequencies of the human apolipoprotein E gene: Climate, local adaptations, and evolutionary history

(2010) Dan T.A. Eisenberg et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

(2010) Jia Yao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female mice similar to that in aged males

(2010) Isabel Baeza et al.   BIOGERONTOLOGY

Immune senescence in aged nonhuman primates☆

(2010) Kristen Haberthur et al.   EXPERIMENTAL GERONTOLOGY

Gender specificity of altered human immune cytokine profiles in aging

(2010) Edward J. Goetzl et al.   FASEB JOURNAL

Menopause and aging: Changes in the immune system—A review

(2010) Cátia Morgado Gameiro et al.   MATURITAS

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-γ-inducible protein-10 by astrocytes exposed to inflammatory challengein vitro

(2009) M. Cerciat et al.   GLIA

ApoE phenotype is associated with inflammatory markers in middle-aged subjects

(2009) O. Ukkola et al.   INFLAMMATION RESEARCH

APOE epsilon-4 allele and cytokine production in Alzheimer's disease

(2009) Paolo Olgiati et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

(2009) Julia Reichwald et al.   Journal of Neuroinflammation

CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior

(2009) R. L. Silverstein et al.   Science Signaling

Prodromal Alzheimer's disease: Successive emergence of the clinical symptoms

(2008) Hélène Amieva et al.   ANNALS OF NEUROLOGY

Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)

(2008)   ARCHIVES OF NEUROLOGY

Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy

(2008) Carol C. Persad et al.   FERTILITY AND STERILITY

Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases

(2008) Elisabetta Vegeto et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs

(2008) Silvia Tapia-Gonzalez et al.   JOURNAL OF ENDOCRINOLOGY

The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era

(2008) Jiqing Xu et al.   Journal of Neuroimmune Pharmacology

Impact of apoE genotype on oxidative stress, inflammation and disease risk

(2008) Laia Jofre-Monseny et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Long-Term Effects of Oophorectomy on Cognitive and Motor Aging Are Age Dependent

(2008) Walter A. Rocca et al.   Neurodegenerative Diseases

Protective effects of NSAIDs on the development of Alzheimer disease

(2008) Steven C. Vlad et al.   NEUROLOGY

Aging of the Immune System as a Prognostic Factor for Human Longevity

(2008) Anis Larbi et al.   PHYSIOLOGY

Gene expression changes in the course of normal brain aging are sexually dimorphic

(2008) N. C. Berchtold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications

(2008) Roberta Diaz Brinton   TRENDS IN NEUROSCIENCES

The APOE4 genotype alters the response of microglia and macrophages to 17β-estradiol

(2007) Candice M. Brown et al.   NEUROBIOLOGY OF AGING

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING