Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

Apolipoprotein E4 Domain Interaction Accelerates Diet-Induced Atherosclerosis in Hypomorphic Arg-61 Apoe Mice

(2012) Delphine Eberlé et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages

(2011) Daniel Baitsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monocyte and Macrophage Dynamics During Atherogenesis

(2011) Klaus Ley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage polarization in metabolic disorders

(2011) Giulia Chinetti-Gbaguidi et al.   CURRENT OPINION IN LIPIDOLOGY

Apolipoprotein E4 Exaggerates Diabetic Dyslipidemia and Atherosclerosis in Mice Lacking the LDL Receptor

(2011) L. A. Johnson et al.   DIABETES

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

(2011) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Apolipoprotein E inhibits Toll-like receptor (TLR)-3- and TLR-4-mediated macrophage activation through distinct mechanisms

(2010) Yanjuan Zhu et al.   BIOCHEMICAL JOURNAL

Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4

(2010) Jose M. Arbones-Mainar et al.   FASEB JOURNAL

Pancreatic acinar cell-specific overexpression of group 1B phospholipase A2 exacerbates diet-induced obesity and insulin resistance in mice

(2010) J G Cash et al.   INTERNATIONAL JOURNAL OF OBESITY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Apolipoprotein E polymorphisms and type 2 diabetes: A meta-analysis of 30 studies including 5423 cases and 8197 controls

(2010) P.G. Anthopoulos et al.   MOLECULAR GENETICS AND METABOLISM

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Apolipoprotein E4 Domain Interaction Induces Endoplasmic Reticulum Stress and Impairs Astrocyte Function

(2009) Ning Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response

(2009) A. Uemura et al.   JOURNAL OF CELL SCIENCE

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

(2009) Edward Thorp et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice

(2008) J M Arbones-Mainar et al.   INTERNATIONAL JOURNAL OF OBESITY

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

(2008) Godfrey S. Getz et al.   JOURNAL OF LIPID RESEARCH

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Impact of apoE genotype on oxidative stress, inflammation and disease risk

(2008) Laia Jofre-Monseny et al.   MOLECULAR NUTRITION & FOOD RESEARCH

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING