Review
Endocrinology & Metabolism
Manon Dubol, C. Neill Epperson, Julia Sacher, Belinda Pletzer, Birgit Derntl, Rupert Lanzenberger, Inger Sundstrom-Poromaa, Erika Comasco
Summary: Increasing evidence suggests that ovarian hormones influence the brain structure, chemistry, and function of women in their reproductive age, potentially shaping their behavior and mental health. Specifically, these hormones fluctuations appear to have modulatory effects on the reactivity and structure of cortico-limbic brain regions.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Review
Geriatrics & Gerontology
Steven Jett, Eva Schelbaum, Grace Jang, Camila Boneu Yepez, Jonathan P. Dyke, Silky Pahlajani, Roberta Diaz Brinton, Lisa Mosconi
Summary: Ovarian hormones play a crucial role in women's cognition, and the decline of 17 beta-estradiol during menopause is associated with cognitive aging and Alzheimer's disease risk.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Hannah K. Ballard, T. Bryan Jackson, Tracey H. Hicks, Sydney J. Cox, Abigail Symm, Ted Maldonado, Jessica A. Bernard
Summary: Sex hormone fluctuations throughout the female lifespan are associated with brain health and cognition, and may contribute to sex differences in brain function and behavior. Sleep patterns, which also show sex-specific effects on the brain and behavior, are correlated with sex hormones. The interplay between hormones and sleep may contribute to late-life brain and behavioral outcomes in females.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Psychology, Clinical
Kristen M. Culbert, Katharine N. Thakkar, Kelly L. Klump
Summary: This narrative review examines the theories behind the heightened risk for psychosis in midlife women and looks at the potential role of ovarian hormones. Studies indicate that the peak ages of midlife psychosis risk in women overlap with the age range of key menopausal stages, especially the perimenopausal transition. However, there is a lack of direct research on menopausal stage. Studies on ovarian hormone effects have mostly focused on earlier developmental stages and events, showing increases in psychotic symptoms during periods of lower estradiol levels. Future research is needed to fill the gaps in our knowledge.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Dan Shan, Shaoyang Li, Ruichen Xu, Glen Nie, Yangyiran Xie, Junchu Han, Xiaoyi Gao, Yuandian Zheng, Zhen Xu, Zhihao Dai
Summary: This study compares and summarizes the literature on the relationship between COVID-19-induced neuropathological changes observed through neuroimaging scans and memory symptoms experienced by recovered patients. The findings suggest a correlation between structural and functional abnormalities in various brain regions, particularly in the frontal, parietal, and temporal regions, and memory impairments in COVID-19 survivors.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Alanna Dorsey, Luis de Lecea, Kimberly J. Jennings
Summary: Sleep plays a crucial role in women's health, and sex differences in sleep quality have significant implications. Ovarian hormones are shown to regulate female sleep by acting on various brain regions and neurochemicals. Future research is needed to focus on these gender differences to improve overall health.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Immunology
Lydia Zeibich, Stephanie Koebele, Victoria E. Bernaud, Zehra Esra Ilhan, Blake Dirks, Steven N. Northup-Smith, Rachel Neeley, Juan Maldonado, Khemlal Nirmalkar, Julia A. Files, Anita P. Mayer, Heather A. Bimonte-Nelson, Rosa Krajmalnik-Brown
Summary: This study using a rat model found that ovariectomy-induced ovarian hormone deficiency and subsequent E2 treatment significantly impacted various health-affecting parameters, including intestinal bacterial taxa abundance, microbial short-chain fatty acids abundance, weight/BMI, and cognitive function. Exploratory correlations among intestinal bacteria abundance, cognition, and BMI highlighted the potential influence of surgical menopause and E2 treatment on gut-brain interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Neurosciences
Nina E. Baumgartner, Shannon M. McQuillen, Samantha F. Perry, Sangtawan Miller, Matthieu J. Maroteaux, Robert B. Gibbs, Jill M. Daniel
Summary: Elevated levels of brain estrogen receptor a (ERa) enhances cognitive aging and short-term estrogen use near menopause can have lasting effects on hippocampal function and memory. Insulin-like growth factor-1 (IGF-1) can activate ERa through ligand-independent mechanisms and requires synthesis of brain-derived neuroestrogens. Decreased neuroestrogen activity and impaired memory in a rat model of menopause can be reversed by short-term estradiol treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Botond Antal, Liam P. McMahon, Syed Fahad Sultan, Andrew Lithen, Deborah J. Wexler, Bradford Dickerson, Eva-Maria Ratai, Lilianne R. Mujica-Parodi
Summary: This study analyzed neuroimaging and cognitive data from a large cohort of individuals with type 2 diabetes mellitus (T2DM) and healthy controls. The findings show that T2DM is associated with significant cognitive deficits and structural and functional brain changes, with overlap with aging effects. The duration of the disease is linked to more severe neurodegeneration. Treatment with metformin does not improve neurocognitive outcomes.
Review
Nutrition & Dietetics
Abbie E. Smith-Ryan, Hannah E. Cabre, Joan M. Eckerson, Darren G. Candow
Summary: Despite the lack of research on creatine use among females, supplementation appears to be effective for improving strength and exercise performance in pre-menopausal women, and may also benefit post-menopausal women in terms of skeletal muscle size and function. Additionally, combining creatine with resistance training may have favorable effects on bone health in post-menopausal women.
Article
Neurosciences
Caroline Demro, Bryon A. Mueller, Jerillyn S. Kent, Philip C. Burton, Cheryl A. Olman, Michael-Paul Schallmo, Kelvin O. Lim, Scott R. Sponheim
Summary: This paper describes an investigation within the Human Connectome Project focusing on psychotic psychopathology, with data collected from clinical assessments, cognitive assessments, motor assessments, blood specimens, and MRI data. The goal is to provide information on data acquisition process for researchers planning to use the publicly available data, with a companion paper detailing the study's 7 Tesla image acquisition protocol.
Review
Endocrinology & Metabolism
Caitlin M. Taylor, Laura Pritschet, Emily G. Jacobs
Summary: The translation raises concerns about the blind spots and neglect in neuroimaging research on women's health, pointing out the current lack of attention to this issue. To address the problem, the suggestion is made for systematic research on the impact of endocrine factors on the brain and highlighting the role of the University of California Women's Brain Initiative.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Robyn P. Thom, Camila Canales, Mary Tresvalles, Christopher J. Mcdougle, Jacob M. Hooker, Yachin Chen, Nicole R. Zuercher
Summary: Williams syndrome (WS) is a genetic disorder that affects multiple organ systems and is characterized by cardiovascular disease, distinct facies, and a unique cognitive profile. Neuroimaging studies have identified morphometric brain differences, including decreased volume in the parieto-occipital region and increased cerebellar volume. Studies have also found dysfunction in the dorsal stream and abnormal activation of the hippocampal formation in relation to the visuospatial deficit. Future research that combines neuroimaging with clinical phenotyping, utilizes novel imaging techniques, and includes homogeneous age groups has the potential to advance clinical care for WS.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
C'iana P. Cooper, Andrea T. Shafer, Nicole M. Armstrong, Yang An, Guray Erus, Christos Davatzikos, Luigi Ferrucci, Peter R. Rapp, Susan M. Resnick
Summary: This study investigated the association between cerebellar volume and verbal learning and memory. The findings suggest that decline in cerebellar white matter volume is associated with decline in verbal memory, while preserved cerebellar gray matter volume is associated with less decline in verbal learning and memory. These results indicate that the association between cerebellar volume and verbal learning and memory is age-dependent and regionally specific.
Article
Clinical Neurology
Ashley A. Yttredahl, Erin McRobert, Benjamin Sheler, Brian J. Mickey, Tiffany M. Love, Scott A. Langenecker, Jon-Kar Zubieta, David T. Hsu
JOURNAL OF AFFECTIVE DISORDERS
(2018)
Article
Obstetrics & Gynecology
Alison Berent-Spillson, Angela S. Kelley, Carol C. Persad, Tiffany Love, Kirk A. Frey, Nancy E. Reame, Robert Koeppe, Jon-Ka Zubieta, Yolanda R. Smith
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2018)
Article
Behavioral Sciences
Anjali Sankar, Ashley A. Yttredahl, Elizabeth W. Fourcade, Brian J. Mickey, Tiffany M. Love, Scott A. Langenecker, David T. Hsu
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
David T. Hsu, Anjali Sankar, Mohammad A. Malik, Scott A. Langenecker, Brian J. Mickey, Tiffany M. Love
SOCIAL NEUROSCIENCE
(2020)
Article
Psychiatry
Hannah M. Wright, Brandon J. Griffin, Kotaro Shoji, Tiffany M. Love, Scott A. Langenecker, Charles C. Benight, Andrew J. Smith
Summary: The study assessed the mental health risks faced by emergency and hospital personnel during the COVID-19 pandemic, revealing higher rates of emotional disorders and mental health issues under emergency situations. Factors such as immunocompromised conditions, job responsibilities, and family situations were closely associated with mental health risks.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Correction
Neurosciences
Katherine G. Warthen, Alita Boyse-Peacor, Keith G. Jones, Benjamin Sanford, Tiffany M. Love, Brian J. Mickey
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Scott A. Langenecker, Mindy Westlund Schreiner, Leah R. Thomas, Katie L. Bessette, Sophia R. DelDonno, Lisanne M. Jenkins, Rebecca E. Easter, Jonathan P. Stange, Stephanie L. Pocius, Alina Dillahunt, Tiffany M. Love, K. Luan Phan, Vincent Koppelmans, Martin Paulus, Martin A. Lindquist, Brian Caffo, Brian J. Mickey, Robert C. Welsh
Summary: Resting-state graph-based network edges can be integrated with RDoC constructs for accurate identification of mood disorder-related markers. However, prior network models may lack sufficient diagnostic clarity, and parcel-based edges may be insufficiently sensitive for these purposes.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Psychiatry
Javier Ballester, Anne K. Baker, Ilkka K. Martikainen, Vincent Koppelmans, Jon-Kar Zubieta, Tiffany M. Love
Summary: This study found that chronic pain patients at high risk for opioid misuse showed higher baseline MOR availability in the right amygdala, while patients at low risk for opioid misuse showed less pain-induced activation of MOR-mediated, endogenous opioid neurotransmission in the nucleus accumbens.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Tiffany Love, Andrey A. Shabalin, Rachel L. Kember, Anna R. Docherty, Hang Zhou, Vincent Koppelmans, Joel Gelernter, Anne K. Baker, Emily Hartwell, Jacob Dubroff, Jon-Kar Zubieta, Henry R. Kranzler
Summary: This study found a link between polygenic risk for major depressive disorder (MDD) and opioid use disorder (OUD) and opioid system activity, particularly under stress. The association was most significant among females and may help explain the high comorbidity between MDD and OUD. The results also suggest that opioid-modulating interventions may be useful in treating MDD and OUD.
NEUROPSYCHOPHARMACOLOGY
(2022)
Correction
Psychiatry
Andrew J. Smith, Kotaro Shoji, Brandon J. Griffin, Lauren M. Sippel, Emily R. Dworkin, Hannah M. Wright, Ellen Morrow, Amy Locke, Tiffany M. Love, J. Irene Harris, Krzysztof Kaniasty, Scott A. Langenecker, Charles C. Benight
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
Andrew J. Smith, Kotaro Shoji, Brandon J. Griffin, Lauren M. Sippel, Emily R. Dworkin, Hannah M. Wright, Ellen Morrow, Amy Locke, Tiffany M. Love, J. Irene Harris, Krzysztof Kaniasty, Scott A. Langenecker, Charles C. Benight
Summary: This study examined pathways to resilience in healthcare workers and confirmed the importance of received social support and coping self-efficacy in mitigating psychopathology risk.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Neurosciences
Anne K. Baker, Lauren C. Ericksen, Vincent Koppelmans, Brian J. Mickey, Katherine T. Martucci, Jon-Kar Zubieta, Tiffany M. Love
Summary: There is a reciprocal relationship between chronic pain and reward processing. This study found that males with chronic pain exhibited reduced anticipatory responses to reward in the striatum compared to control males, while no significant sex differences were observed among female patients. These findings highlight the importance of considering sex as a factor of interest in future studies on reward processing in the context of chronic pain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Scott A. Langenecker, Brian J. Mickey, Peter Eichhammer, Srijan Sen, Kathleen H. Elverman, Susan E. Kennedy, Mary M. Heitzeg, Saulo M. Ribeiro, Tiffany M. Love, David T. Hsu, Robert A. Koeppe, Stanley J. Watson, Huda Akil, David Goldman, Margit Burmeister, Jon-Kar Zubieta
FRONTIERS IN PSYCHOLOGY
(2019)
Article
Substance Abuse
Tiffany M. Love, James A. Cranford, Margit Burmeister, Marcin Wojnar, Robert A. Zucker, Kirk J. Brower
ALCOHOL AND ALCOHOLISM
(2018)
Review
Behavioral Sciences
Tiffany M. Love
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2018)