Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples

(2013) Andrew D. Watt et al.   ACTA NEUROPATHOLOGICA

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy

(2013) Alex E. Roher et al.   PLoS One

Detection of Amyloid Plaques Targeted by Bifunctional USPIO in Alzheimer’s Disease Transgenic Mice Using Magnetic Resonance Microimaging

(2013) Youssef Zaim Wadghiri et al.   PLoS One

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Alzheimer Disease in 2020

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Biochemistry of Amyloid  -Protein and Amyloid Deposits in Alzheimer Disease

(2013) C. L. Masters et al.   Cold Spring Harbor Perspectives in Medicine

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Immunotherapy for Alzheimer’s disease: from anti-β-amyloid to tau-based immunization strategies

(2012) Francesco Panza et al.   Immunotherapy

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Active immunotherapy for Alzheimer's disease

(2012) Thomas Wisniewski   LANCET NEUROLOGY

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

(2011) Yadong Huang   BIOCHEMICAL SOCIETY TRANSACTIONS

Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors

(2011) Magnus Stougaard et al.   Integrative Biology

High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

(2011) Ajeet Rijal Upadhaya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

(2011) Allal Boutajangout et al.   JOURNAL OF NEUROCHEMISTRY

Prion Disease Detection, PMCA Kinetics, and IgG in Urine from Sheep Naturally/Experimentally Infected with Scrapie and Deer with Preclinical/Clinical Chronic Wasting Disease

(2011) R. Rubenstein et al.   JOURNAL OF VIROLOGY

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Mapping ApoE/Aβ binding regions to guide inhibitor discovery

(2011) Qian Liu et al.   Molecular BioSystems

A Battle No Soldier Wants to Fight

(2011) G. Miller   SCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an alzheimer's disease model mouse

(2010) Erika Chung et al.   BMC NEUROSCIENCE

High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients

(2010) Hiroaki Fukumoto et al.   FASEB JOURNAL

Spectroscopic Studies of GSK3β Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E

(2010) Arnaud Leroy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

Aβ20–29 peptide blocking apoE/Aβ interaction reduces full-length Aβ42/40 fibril formation and cytotoxicity in vitro

(2010) Jian Hao et al.   NEUROPEPTIDES

Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease

(2010) Fernando Goñi et al.   PLoS One

Apolipoprotein E: From lipid transport to neurobiology

(2010) Paul S. Hauser et al.   PROGRESS IN LIPID RESEARCH

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Alzheimer disease: Multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches

(2009) Robert W. Mahley et al.   ANNALS OF NEUROLOGY

Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models

(2009) Thomas Wisniewski et al.   Brain Structure & Function

Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology

(2009) H. Scholtzova et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Tg-SwDI Transgenic Mice Exhibit Novel Alterations in AβPP Processing, Aβ Degradation, and Resilient Amyloid Angiopathy

(2008) Gregory D. Van Vickle et al.   AMERICAN JOURNAL OF PATHOLOGY

Preventing β-amyloid fibrillization and deposition: β-sheet breakers and pathological chaperone inhibitors

(2008) Thomas Wisniewski et al.   BMC NEUROSCIENCE

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE