Interaction of materials and biology in total joint replacement – successes, challenges and future directions

What other biologic and mechanical factors might contribute to osteolysis?

(2016) Ed M. Greenfield et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Different influence of Ti, PMMA, UHMWPE, and Co-Cr particles on peripheral blood monocytes during periprosthetic inflammation

(2014) Kai Zhang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Exposure of polyethylene particles induces interferon-γ expression in a natural killer T lymphocyte and dendritic cell coculture systemin vitro: A preliminary study

(2014) Tzu-Hua Lin et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Differential Expression of Chemokines, Chemokine Receptors and Proteinases by Foreign Body Giant Cells (FBGCs) and Osteoclasts

(2014) Usman A. Khan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Missing Elements of the History

(2014) Larry A. Allen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteolysis around total knee arthroplasty: A review of pathogenetic mechanisms

(2013) J. Gallo et al.   Acta Biomaterialia

The response of macrophages to titanium particles is determined by macrophage polarization

(2013) Jukka Pajarinen et al.   Acta Biomaterialia

Chronic inflammation in biomaterial-induced periprosthetic osteolysis: NF-κB as a therapeutic target

(2013) Tzu-hua Lin et al.   Acta Biomaterialia

Macrophage polarization in response to wear particles in vitro

(2013) Joseph K Antonios et al.   Cellular & Molecular Immunology

Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators

(2013) Dessy Rachmawati et al.   CONTACT DERMATITIS

Toll-like receptors-2 and 4 are overexpressed in an experimental model of particle-induced osteolysis

(2013) Roberto D. Valladares et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Macrophages-Key cells in the response to wear debris from joint replacements

(2013) Christophe Nich et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Correlation of Wear with Histological Features After Failed Hip Resurfacing Arthroplasty

(2013) George Grammatopoulos et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Periprosthetic Tissue Metal Content but Not Serum Metal Content Predicts the Type of Tissue Response in Failed Small-Diameter Metal-on-Metal Total Hip Arthroplasties

(2013) C.H Lohmann et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)

(2013) Kristofer Wintges et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Metal ions activate vascular endothelial cells and increase lymphocyte chemotaxis and binding

(2013) James T. Ninomiya et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Increasing both CoCrMo-alloy particle size and surface irregularity induces increased macrophage inflammasome activation in vitro potentially through lysosomal destabilization mechanisms

(2013) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Parthenolide inhibits polyethylene particle–induced mouse calvarial osteolysis in vivo

(2013) Yuwei Li et al.   JOURNAL OF SURGICAL RESEARCH

Alternative Bearings in Total Hip Arthroplasty in the Young Patient

(2013) Atul F. Kamath et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

The role of osteoblasts in peri-prosthetic osteolysis

(2013) S. C. O’Neill et al.   Bone & Joint Journal

Metal-on-metal hips: cobalt can induce an endotoxin-like response

(2012) Alison Jane Tyson-Capper et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of a CCR1 receptor antagonist on systemic trafficking of MSCs and polyethylene particle-associated bone loss

(2012) Emmanuel Gibon et al.   BIOMATERIALS

Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine

(2012) Bryan N. Brown et al.   BIOMATERIALS

Genetic susceptibility to aseptic loosening following total hip arthroplasty: a systematic review

(2012) A. Del Buono et al.   BRITISH MEDICAL BULLETIN

Structural basis of metal hypersensitivity

(2012) Yang Wang et al.   IMMUNOLOGIC RESEARCH

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

(2012) Jiri Gallo et al.   Innate Immunity

Local effect of IL-4 delivery on polyethylene particle induced osteolysis in the murine calvarium

(2012) Allison J. Rao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The Role of TLR and Chemokine in Wear Particle-Induced Aseptic Loosening

(2012) Qiaoli Gu et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Ceramic-on-ceramic bearings in hip arthroplasty

(2012) J. R. T. Jeffers et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Metal hypersensitivity testing in patients undergoing joint replacement

(2012) D. Granchi et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Adverse reactions to metal-on-metal implants

(2012) Yrjö T. Konttinen et al.   Nature Reviews Rheumatology

Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty

(2012) Harinderjit S. Gill et al.   TRENDS IN MOLECULAR MEDICINE

Risk of cancer with metal-on-metal hip replacements: population based study

(2012) K. T. Makela et al.   BMJ-British Medical Journal

Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics

(2012) A. J. Smith et al.   BMJ-British Medical Journal

Radiographic Assessment of Implant Failures of Titanium 3.5 LCP vs. 4.5 LCP Used for Flexible Bridging Osteosynthesis of Large Segmental Femoral Diaphyseal Defects in a Miniature Pig Model

(2011) Alois Nečas et al.   ACTA VETERINARIA BRNO

Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles

(2011) Jeremy I. Pearl et al.   BIOMATERIALS

The stimulation of an osteogenic response by classical monocyte activation

(2011) Omar M. Omar et al.   BIOMATERIALS

Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: Implications for skeletal health

(2011) Rebecca E. Andrews et al.   BONE

History and Systematic Review of Wear and Osteolysis Outcomes for First-generation Highly Crosslinked Polyethylene

(2011) Steven M. Kurtz et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Macrophage reactivity to different polymers demonstrates particle size- and material-specific reactivity: PEEK-OPTIMA® particles versus UHMWPE particles in the submicron, micron, and 10 micron size ranges

(2011) Nadim James Hallab et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of metal-on-metal hip replacement

(2011) A. J. Hart et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Nickel allergies: paying the Toll for innate immunity

(2011) Marc Schmidt et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles

(2011) Tomoyuki Hirayama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cobalt and chromium ions reduce human osteoblast-like cell activity in vitro, reduce the OPG to RANKL ratio, and induce oxidative stress

(2011) Wierd P. Zijlstra et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles

(2011) Emmanuel Gibon et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Aseptic Lymphocyte-Dominated Vasculitis-Associated Lesion

(2010) Tyler Steven Watters et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Cellular chemotaxis induced by wear particles from joint replacements

(2010) Stuart B. Goodman et al.   BIOMATERIALS

Perivascular Lymphocytic Infiltration Is Not Limited to Metal-on-Metal Bearings

(2010) Vincent Y. Ng et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Perivascular and Diffuse Lymphocytic Inflammation are not Specific for Failed Metal-on-metal Hip Implants

(2010) Takaaki Fujishiro et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Histological Features of Pseudotumor-like Tissues From Metal-on-Metal Hips

(2010) Pat Campbell et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Bacterial Pathogen-associated Molecular Patterns Stimulate Biological Activity of Orthopaedic Wear Particles by Activating Cognate Toll-like Receptors

(2010) Edward M. Greenfield et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profile of toll-like receptor-positive cells in septic and aseptic loosening of total hip arthroplasty implants

(2010) Jukka Pajarinen et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Arthroprosthetic Cobaltism: Neurological and Cardiac Manifestations in Two Patients with Metal-on-Metal Arthroplasty

(2010) Stephen S Tower   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Altered adherent leukocyte profile on biomaterials in Toll-like receptor 4 deficient mice

(2009) Todd H. Rogers et al.   BIOMATERIALS

Over-expression of receptor activator of nuclear factor-κB ligand (RANKL), inflammatory cytokines, and chemokines in periprosthetic osteolysis of loosened total hip arthroplasty

(2009) Chen-Ti Wang et al.   BIOMATERIALS

Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study

(2009) Jiri Gallo et al.   BMC Medical Genetics

Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: A preliminary study

(2009) F. Mrazek et al.   HUMAN IMMUNOLOGY

Cobalt ions induce chemokine secretion in primary human osteoblasts

(2009) J.M. Queally et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Increased Expression of Toll-like Receptors in Aseptic Loose Periprosthetic Tissues and Septic Synovial Membranes Around Total Hip Implants

(2009) Y. TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty

(2008) Andrew Gordon et al.   ARTHRITIS AND RHEUMATISM

Biocompatibility of total joint replacements: A review

(2008) Stuart B. Goodman et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biological response to micron- and nanometer-sized particles known as potential wear products from artificial hip joints: Part II: Reaction of murine macrophages to corundum particles of different size distributions

(2008) I. Kranz et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Metal Ion Measurement as a Diagnostic Tool to Identify Problems with Metal-on-Metal Hip Resurfacing

(2008) K De Smet et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Polymethylmethacrylate particles inhibit osteoblastic differentiation of MC3T3-E1 osteoprogenitor cells

(2008) Richard Chiu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: A novel mechanism for implant debris reactivity

(2008) Marco S. Caicedo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty

(2008) Nadim Hallab et al.   Journal of Orthopaedic Surgery and Research