Article
Immunology
Laura A. Mckiel, Laurel L. Ballantyne, Gian Luca Negri, Kimberly A. Woodhouse, Lindsay E. Fitzpatrick
Summary: The adsorption of damage-associated molecular patterns (DAMPs) derived from damaged cells and matrix surrounding the implant on the surface of implanted biomaterial plays a significant role in downstream cell-material interactions. This study shows that DAMPs and other intracellular proteins can readily adsorb to biomaterial surfaces and induce an inflammatory response in adherent macrophages through the MyD88-dependent Toll-like receptor 2 (TLR2) signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Marta Maria Gaglia
Summary: TLRs play a crucial role in anti-viral responses, especially against oncogenic herpesviruses. They not only act directly in infected cells, but also in responding cells of the immune system. Research indicates that TLR activity may drive herpesviruses to re-enter the replicative lytic cycle.
Article
Anatomy & Morphology
Yanhong Mi, Xiaoxiao Xie, Zhongkun Bao, Xiaoyu Xiong, Xinhong Wang, Hongxi Zhang
Summary: The study aimed to investigate the protective effect of dimethyl fumarate (DMF) on necrotizing enterocolitis (NEC) and its mechanism. Results showed that DMF attenuated NEC-induced weight loss and abdominal distension diarrhea, alleviated intestinal pathological injuries, and inhibited intestinal cell apoptosis. These effects were related to the inhibition of the TLR signaling pathway and alleviation of the inflammatory response.
Article
Cell Biology
Liming Xu, Xuegang Niu, Yifan Liu, Lining Liu
Summary: This study investigates the role of ST3GAL3 in rheumatoid arthritis (RA) and its potential mechanism of action. The findings suggest that ST3GAL3 may be involved in RA pathogenesis by activating the TLR9/MyD88 pathway.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhang, Guangshuai Liu, Tian Xia, Xiufeng Yang, Guolei Sun, Chao Zhao, Chunzhu Xu, Honghai Zhang
Summary: The study analyzed TLR genes from the genomes and transcriptomes of 102 amphibian species to understand their evolutionary patterns. Results showed that TLR genes can be divided into seven subfamilies, with TLR4 subfamily found only in Anura. Purification selection played a leading role in amphibian TLR evolution, and different domains had different evolution rates. Positive selection patterns and single-nucleotide polymorphisms were observed in TLR genes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Benjamin Panzer, Christoph W. Kopp, Christoph Neumayer, Renate Koppensteiner, Alicja Jozkowicz, Michael Poledniczek, Thomas Gremmel, Bernd Jilma, Patricia P. Wadowski
Summary: Toll-like receptors (TLRs) play a critical role in viral infections by inducing pro-inflammatory responses and disrupting vascular homeostasis. The injury to the vessel wall leads to pro-thrombotic processes and eventually causes micro-vessel plugging and tissue necrosis. TLRs also directly contribute to virus sensing and platelet activation. Upregulation of von Willebrand factor release and extra-cellular trap formation by TLRs further enhance thrombotic processes during inflammation. This review focuses on TLR signaling pathways in humans, which provoke pro-thrombotic responses during viral infections, particularly in individuals with cardiovascular diseases.
Review
Chemistry, Multidisciplinary
Xin Zhi, Peipei Yang, Yunxue Xu, Zhifei Dai, Xiuli Yue, Linxue Qian
Summary: This review discusses the functions of Toll-like receptors (TLRs) in the tumor microenvironment and the pathways that activate immune responses. It also summarizes recent developments in nanotechnology for immunomodulation with TLR agonists. Nanotechnology can improve the efficacy of TLR agonist-based immunotherapy and address its limitations.
Review
Biochemistry & Molecular Biology
Yuan-Tung Chu, Min-Tser Liao, Kuo-Wang Tsai, Kuo-Cheng Lu, Wan-Chung Hu
Summary: A comprehensive framework has been established to understand immunological pathways, and specific associations between immune responses and immune receptors have been identified. These findings contribute to the identification of biomarkers for immune cells and provide insights into host immunological pathways.
Article
Multidisciplinary Sciences
Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell, Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, Chi V. Dang
Summary: By investigating inflammatory signaling pathways in neuroblastoma, researchers have identified heterogeneity in dsRNA sensing and intratumoral inflammatory signaling, which has significant implications for immunotherapeutic strategies in this aggressive childhood cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Emine Bozkurtlar, Kevser Oksuzoglu, Korkut Bostanci, Sezer Aslan, Tugba Nergiz Kissa, Derya Kocakaya, Tunc Ones
Summary: This study evaluated the postoperative imaging features of polysaccharide-based hemostatic agents in thoracic surgery patients. Polysaccharide-based agents were detected in histopathological samples and were associated with chronic inflammatory reactions. Additionally, these agents may result in false-positive findings on postoperative FDG PET/CT scans.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Immunology
Andres F. Londono, Diana G. G. Scorpio, J. Stephen Dumler
Summary: Rickettsial agents are diverse alpha-proteobacteria that can cause human diseases. They are mainly transmitted by arthropod vectors and have evolved various mechanisms to evade the host innate immune responses. This review focuses on the mechanisms used by two common rickettsial agents, Rickettsia species and Anaplasma phagocytophilum, to survive within and propagate from host cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Zoology
Qianqian Su, Yi Chen, Bo Wang, Qingxun Zhang, Hongxuan He
Summary: The study investigated the genetic characteristics and evolution of Toll-like receptors in wild brown rats, revealing high genetic diversity in TLR8 and low genetic diversity in TLR2. Findings indicated that genetic variations in TLR2 and TLR8 were associated with Bartonella and HEV infection, respectively.
INTEGRATIVE ZOOLOGY
(2022)
Article
Cell Biology
Friedrich Barsch, Andreas Mamilos, Volker H. Schmitt, Maximilian Babel, Lina Winter, Willi Wagner, Hinrich Winther, Christian Ottomann, Tanja Niedermair, Stephan Schreml, Helmut Hierlemann, Christoph Brochhausen
Summary: Synthetic macroporous biomaterials are widely used in skin tissue engineering to mimic native dermis functions. However, they often face limitations due to unfavorable foreign body responses. This study compared the foreign body responses of two different 3D matrix designs and found that the matrix design significantly affected the responses.
Review
Biochemistry & Molecular Biology
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu
Summary: Platelets, as the second most abundant blood component, play a crucial role in various physiological and pathological functions. In addition to its traditional role in hemostasis and thrombosis, platelets also have an indispensable role in inflammatory diseases. Thrombocytopenia, a common hematologic problem, is closely related to the fatality of many diseases, highlighting the significance of its prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Stavros Garantziotis, Rashmin C. Savani
Summary: The extracellular matrix (ECM) is not only a structure but also plays key roles in cellular responses. Proteoglycans (PGs), a component of ECM, have been found to be crucial in both health maintenance and disease development by activating the innate immune system and influencing cell fate.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Engineering, Biomedical
Enrique Gomez-Barrena, Philippe Rosset, Florian Gebhard, Philippe Hernigou, Nicola Baldini, Helene Rouard, Luc Sensebe, Rosa M. Gonzalo-Daganzo, Rosaria Giordano, Norma Padilla-Eguiluz, Eduardo Garcia-Rey, Jose Cordero-Ampuero, Juan Carlos Rubio-Suarez, Julien Stanovici, Christian Ehrnthaller, Markus Huber-Lang, Charles Henri Flouzat-Lachaniette, Nathalie Chevallier, Davide Maria Donati, Gabriela Ciapetti, Sandrine Fleury, Manuel-Nicolas Fernandez, Jose-Rafael Cabrera, Cristina Avendano-Sola, Tiziana Montemurro, Carmen Panaitescu, Elena Veronesi, Markus Thomas Rojewski, Ramin Lotfi, Massimo Dominici, Hubert Schrezenmeier, Pierre Layrolle
Editorial Material
Medicine, General & Internal
Enrique Gomez-Barrena, Eduardo Garcia-Rey
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Critical Care Medicine
Enrique Gomez-Barrena, Norma G. Padilla-Eguiluz, Eduardo Garcia-Rey, Pablo Hernandez-Esteban, Jose Cordero-Ampuero, Juan C. Rubio-Suarez
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2020)
Article
Critical Care Medicine
Enrique Gomez-Barrena, Norma Padilla-Eguiluz, Philippe Rosset, Florian Gebhard, Philippe Hernigou, Nicola Baldini, Helene Rouard, Luc Sensebe, Rosa-Maria Gonzalo-Daganzo, Rosaria Giordano, Eduardo Garcia-Rey, Jose Cordero-Ampuero, Juan Carlos Rubio-Suarez, Marta Dominguez Garcia-Simon, Julien Stanovici, Christian Ehrnthaller, Markus Huber-Lang, Charles Henri Flouzat-Lachaniette, Nathalie Chevallier, Davide Maria Donati, Benedetta Spazzoli, Gabriela Ciapetti, Sandrine Fleury, Manuel-Nicolas Fernandez, Jose-Rafael Cabrera, Cristina Avendano-Sola, Tiziana Montemurro, Carmen Panaitescuk, Elena Veronesi, Markus Thomas Rojewskit, Ramin Lotfi, Massimo Dominici, Hubert Schrezenmeier, Pierre Layrolle
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2020)
Article
Orthopedics
Nanne P. Kort, Luigi Zagra, Enrique Gomez Barrena, Reha N. Tandogan, Martin Thaler, James R. Berstock, Theofilos Karachalios
Article
Medicine, General & Internal
Hanna Perez-Chrzanowska, Norma G. Padilla-Eguiluz, Enrique Gomez-Barrena
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Critical Care Medicine
Norma G. Padilla-Eguiluz, Enrique Gomez-Barrena
Summary: This study provides a descriptive analysis of long bone non-union epidemiology in Spain, showing a stable overall non-union rate with higher rates in the femur and tibia. Non-unions were more frequent in aged females compared to males in the femur and humerus.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Medicine, General & Internal
Enrique Gomez-Barrena, Norma G. Padilla-Eguiluz
Summary: The study evaluated the efficacy of bone forage technique in treating early osteonecrosis of the femoral head, finding that positioning the drilling within the weight-bearing area in the coronal plane and avoiding varus positioning can lead to better outcomes. In the transverse plane, anterior positioning of the drill did not result in improved outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Jaime Esteban, Enrique Gomez-Barrena
Summary: Despite different criteria for diagnosing prosthetic joint infections, identifying the causing microorganism through molecular biology techniques is crucial for guiding treatment. Multiplex polymerase chain reaction methods demonstrate high specificity and sensitivity in clinical cases, and next-generation metagenomics may further enhance sensitivity while maintaining specificity. Molecular biology techniques are expected to significantly transform current microbiological diagnosis of PJI in the next five years.
EFORT OPEN REVIEWS
(2021)
Article
Orthopedics
Enrique Gomez-Barrena, Israel Rubio-Saez, Norma G. Padilla-Eguiluz, Pablo Hernandez-Esteban
Summary: Factors influencing patient's availability to re-schedule knee replacement surgery after the COVID-19 lockdown include age, type of surgery, and pain level. Most patients were willing to undergo surgery in less than a month, but factors such as age and severity of pain significantly impacted patient preference.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Clinical Neurology
Carlos Gavin, Francisco J. Blanco, Jose L. Pablos, Miguel A. Caracuel, Jose Rosas, Enrique Gomez-Barrena, Francisco Navarro, Maria Pilar Coronel, Mercedes Gimeno
Summary: The study demonstrates that a new formulation of hyaluronic acid with a single injection is effective in treating patients with knee osteoarthritis, significantly improving pain, stiffness, and physical function. Patient tolerability and safety were also optimal.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Orthopedics
Giorgio Perino, Ivan De Martino, Lingxin Zhang, Zhidao Xia, Jiri Gallo, Shonali Natu, David Langton, Monika Huber, Anastasia Rakow, Janosch Schoon, Enrique Gomez-Barrena, Veit Krenn
Summary: The histopathological examination of periprosthetic soft tissue and bone has helped identify and describe the morphological features of ALTR/ARMD. A uniform vocabulary and clarification of classification parameters are considered essential for meaningful interdisciplinary evaluation.
EFORT OPEN REVIEWS
(2021)
Article
Medicine, General & Internal
Jeffrey Weitz, John Strony, Walter Ageno, David Gailani, Elaine M. Hylek, Michael R. Lassen, Kenneth W. Mahaffey, Ravi S. Notani, Robin Roberts, Annelise Segers, Gary E. Raskob
Summary: The study results showed that in knee arthroplasty patients receiving different doses of milvexian treatment, the incidence of venous thromboembolism with twice-daily dosing was significantly lower than the prespecified benchmark of 30%, with a lower risk of bleeding compared to enoxaparin.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Enrique Gomez-Barrena, Timothy Warren, Ian Walker, Neil Jain, Nanne Kort, Francois Loubignac, Simon Newman, Carsten Perka, Antonio Spinarelli, Michael R. Whitehouse, Luigi Zagra, Basilio J. de la Torre
Summary: There is an important consensus among orthopedic surgeons regarding the prevention of periprosthetic joint infection, although improvements can still be made in certain specific measures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Enrique Gomez-Barrena, Juan C. Rubio-Suarez, Nicomedes Fernandez-Baillo, Samuel Antuna, Ana Cruz-Pardos, Manuel Blanco, Eduardo Ortiz-Cruz, Gaspar Gonzalez-Moran, Enrique Gil-Garay
JOURNAL OF SURGICAL CASE REPORTS
(2020)