PRDM9, a driver of the genetic map

PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites

(2018) Boubou Diagouraga et al.   MOLECULAR CELL

Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice

(2018) Sona Gregorova et al.   eLife

Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction

(2017) Sophie Tessé et al.   GENES & DEVELOPMENT

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

(2017) Corinne Grey et al.   GENOME RESEARCH

PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis

(2017) Emil D. Parvanov et al.   MOLECULAR BIOLOGY OF THE CELL

The Red Queen model of recombination hot-spot evolution: a theoretical investigation

(2017) Thibault Latrille et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

(2017) Nicolas Altemose et al.   eLife

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

(2017) Zachary Baker et al.   eLife

Evidence of positive selection and concerted evolution in the rapidly evolvingPRDM9zinc finger domain in goats and sheep

(2016) S. Ahlawat et al.   ANIMAL GENETICS

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

(2016) Stephen Gray et al.   Annual Review of Genetics

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair

(2016) Julian Lange et al.   CELL

The evolutionary turnover of recombination hot spots contributes to speciation in mice

(2016) Fatima Smagulova et al.   GENES & DEVELOPMENT

Structural basis for human PRDM9 action at recombination hot spots

(2016) Anamika Patel et al.   GENES & DEVELOPMENT

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase

(2016) Levi L. Blazer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

(2016) Benjamin Davies et al.   NATURE

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice

(2016) Marcello Stanzione et al.   NATURE CELL BIOLOGY

Evolutionary mysteries in meiosis

(2016) Thomas Lenormand et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations

(2016) Sonika Ahlawat et al.   PLoS One

A DNA topoisomerase VI-like complex initiates meiotic recombination

(2016) N. Vrielynck et al.   SCIENCE

The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation

(2016) T. Robert et al.   SCIENCE

Health and population effects of rare gene knockouts in adult humans with related parents

(2016) V. M. Narasimhan et al.   SCIENCE

Mechanisms of germ line genome instability

(2016) Seoyoung Kim et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo

(2016) Natalie R. Powers et al.   PLoS Genetics

The pioneering role of PRDM9 indel mutations in tarsier evolution

(2016) Sacha Heerschop et al.   Scientific Reports

Identification of C2H2-ZF binding preferences from ChIP-seq data using RCADE: Fig. 1.

(2015) Hamed S. Najafabadi et al.   BIOINFORMATICS

Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis

(2015) Fengyun Sun et al.   CHROMOSOMA

MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

(2015) R. Kumar et al.   JOURNAL OF CELL SCIENCE

The Time Scale of Recombination Rate Evolution in Great Apes

(2015) Laurie S. Stevison et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolution ofPrdmGenes in Animals: Insights from Comparative Genomics

(2015) Michel Vervoort et al.   MOLECULAR BIOLOGY AND EVOLUTION

Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast

(2015) I. Lam et al.   SCIENCE

Stable recombination hotspots in birds

(2015) S. Singhal et al.   SCIENCE

Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage

(2015) Michael Walker et al.   Epigenetics & Chromatin

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

(2015) Christopher L. Baker et al.   PLoS Genetics

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots

(2015) Christopher L. Baker et al.   PLoS Genetics

Enhancer Runaway and the Evolution of Diploid Gene Expression

(2015) Frédéric Fyon et al.   PLoS Genetics

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family

(2015) Gernot Wolf et al.   Mobile DNA

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques

(2014) Xiaoying Koh-Stenta et al.   BIOCHEMICAL JOURNAL

Allelic variants ofPRDM9associated with high hyperdiploid childhood acute lymphoblastic leukaemia

(2014) Eleanor L. Woodward et al.   BRITISH JOURNAL OF HAEMATOLOGY

Prdm9 Polymorphism Unveils Mouse Evolutionary Tracks

(2014) H. Kono et al.   DNA RESEARCH

PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration

(2014) C. L. Baker et al.   GENOME RESEARCH

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

(2014) Mohammad S. Eram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

(2014) Frank M. J. Jacobs et al.   NATURE

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics

(2014) Francesca Cole et al.   NATURE GENETICS

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An improved predictive recognition model for Cys2-His2 zinc finger proteins

(2014) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite

(2014) Jérôme Buard et al.   PLoS One

The B-Subdomain of the Xenopus laevis XFIN KRAB-AB Domain Is Responsible for Its Weaker Transcriptional Repressor Activity Compared to Human ZNF10/Kox1

(2014) Nadine Born et al.   PLoS One

Genetic recombination variation in wild Robertsonian mice: on the role of chromosomal fusions and Prdm9 allelic background

(2014) L. Capilla et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Recombination initiation maps of individual human genomes

(2014) F. Pratto et al.   SCIENCE

Primate evolution of the recombination regulator PRDM9

(2014) Jerrod J. Schwartz et al.   Nature Communications

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

The Red Queen Model of Recombination Hotspots Evolution in the Light of Archaic and Modern Human Genomes

(2014) Yann Lesecque et al.   PLoS Genetics

Recombination in the Human Pseudoautosomal Region PAR1

(2014) Anjali G. Hinch et al.   PLoS Genetics

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

Initiation of Meiotic Recombination: How and Where? Conservation and Specificities Among Eukaryotes

(2013) Bernard de Massy   Annual Review of Genetics

A fine-scale recombination map of the human-chimpanzee ancestor reveals faster change in humans than in chimpanzees and a strong impact of GC-biased gene conversion

(2013) K. Munch et al.   GENOME RESEARCH

Dissecting the Structure and Mechanism of a Complex Duplication-Triplication Rearrangement in theDMDGene

(2013) Aliya Ishmukhametova et al.   HUMAN MUTATION

Meiotic Recombination Strongly Influences GC-Content Evolution in Short Regions in the Mouse Genome

(2013) Yves Clément et al.   MOLECULAR BIOLOGY AND EVOLUTION

De novo prediction of DNA-binding specificities for Cys2His2 zinc finger proteins

(2013) Anton V. Persikov et al.   NUCLEIC ACIDS RESEARCH

Characterization of Prdm9 in Equids and Sterility in Mules

(2013) Cynthia C. Steiner et al.   PLoS One

Mechanistic basis of infertility of mouse intersubspecific hybrids

(2013) T. Bhattacharyya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

(2013) Hong Wu et al.   Cell Reports

Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs

(2013) Adam Auton et al.   PLoS Genetics

DNA binding specificities of the long zinc-finger recombination protein PRDM9

(2013) Timothy Billings et al.   GENOME BIOLOGY

The Prdm family: expanding roles in stem cells and development

(2012) T. Hohenauer et al.   DEVELOPMENT

Rare allelic forms of PRDM9 associated with childhood leukemogenesis

(2012) J. Hussin et al.   GENOME RESEARCH

Sensitive mapping of recombination hotspots using sequencing-based detection of ssDNA

(2012) P. P. Khil et al.   GENOME RESEARCH

A major recombination hotspot in the XqYq pseudoautosomal region gives new insight into processing of human gene conversion events

(2012) Shriparna Sarbajna et al.   HUMAN MOLECULAR GENETICS

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Genetic recombination is directed away from functional genomic elements in mice

(2012) Kevin Brick et al.   NATURE

High Diversity at PRDM9 in Chimpanzees and Bonobos

(2012) Linn Fenna Groeneveld et al.   PLoS One

Recombination regulator PRDM9 influences the instability of its own coding sequence in humans

(2012) A. J. Jeffreys et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

(2012) A. Auton et al.   SCIENCE

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility

(2012) Petr Flachs et al.   PLoS Genetics

PRDM proteins: Important players in differentiation and disease

(2011) Cathrine K. Fog et al.   BIOESSAYS

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation

(2011) Jing Pan et al.   CELL

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome

(2011) E. Axelsson et al.   GENOME RESEARCH

Genome-wide analysis reveals novel molecular features of mouse recombination hotspots

(2011) Fatima Smagulova et al.   NATURE

Prdm9, a Major Determinant of Meiotic Recombination Hotspots, Is Not Functional in Dogs and Their Wild Relatives, Wolves and Coyotes

(2011) Violeta Muñoz-Fuentes et al.   PLoS One

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations

(2011) I. L. Berg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What are the genomic drivers of the rapid evolution of PRDM9?

(2011) Chris P. Ponting   TRENDS IN GENETICS

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination

(2011) Corinne Grey et al.   PLOS BIOLOGY

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

(2010) Aaron Klug   Annual Review of Biochemistry

Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice

(2010) R. Kumar et al.   GENES & DEVELOPMENT

Fine-scale recombination rate differences between sexes, populations and individuals

(2010) Augustine Kong et al.   NATURE

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

(2010) Ingrid L Berg et al.   NATURE GENETICS

What drives recombination hotspots to repeat DNA in humans?

(2010) G. McVean   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Prdm9 Controls Activation of Mammalian Recombination Hotspots

(2010) E. D. Parvanov et al.   SCIENCE

Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

(2010) S. Myers et al.   SCIENCE

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

Biased Gene Conversion and the Evolution of Mammalian Genomic Landscapes

(2009) Laurent Duret et al.   Annual Review of Genomics and Human Genetics

Distinct histone modifications define initiation and repair of meiotic recombination in the mouse

(2009) Jérôme Buard et al.   EMBO JOURNAL

Single-Nucleotide Polymorphisms of the PRDM9 (MEISETZ) Gene in Patients With Nonobstructive Azoospermia

(2009) S. Irie et al.   JOURNAL OF ANDROLOGY

Extraordinary Molecular Evolution in the PRDM9 Fertility Gene

(2009) James H. Thomas et al.   PLoS One

Genome-Wide Control of the Distribution of Meiotic Recombination

(2009) Corinne Grey et al.   PLOS BIOLOGY

Trans-Regulation of Mouse Meiotic Recombination Hotspots by Rcr1

(2009) Emil D Parvanov et al.   PLOS BIOLOGY

Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa

(2009) Peter L. Oliver et al.   PLoS Genetics

Adaptive Evolution in Zinc Finger Transcription Factors

(2009) Ryan O. Emerson et al.   PLoS Genetics

Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest

(2008) Toshinobu Miyamoto et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

A common sequence motif associated with recombination hot spots and genome instability in humans

(2008) Simon Myers et al.   NATURE GENETICS

A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase

(2008) O. Mihola et al.   SCIENCE

The Recombinational Anatomy of a Mouse Chromosome

(2008) Kenneth Paigen et al.   PLoS Genetics