The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo

Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis

(2015) Fengyun Sun et al.   CHROMOSOMA

Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage

(2015) Michael Walker et al.   Epigenetics & Chromatin

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

(2015) Christopher L. Baker et al.   PLoS Genetics

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques

(2014) Xiaoying Koh-Stenta et al.   BIOCHEMICAL JOURNAL

Prdm9 Polymorphism Unveils Mouse Evolutionary Tracks

(2014) H. Kono et al.   DNA RESEARCH

PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration

(2014) C. L. Baker et al.   GENOME RESEARCH

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

(2014) Mohammad S. Eram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Diversity of Prdm9 Zinc Finger Array in Wild Mice Unravels New Facets of the Evolutionary Turnover of this Coding Minisatellite

(2014) Jérôme Buard et al.   PLoS One

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

How much is enough? Control of DNA double-strand break numbers in mouse meiosis

(2013) Liisa Kauppi et al.   CELL CYCLE

Crossover Heterogeneity in the Absence of Hotspots in Caenorhabditis elegans

(2013) Taniya Kaur et al.   GENETICS

Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters

(2013) Kyuha Choi et al.   NATURE GENETICS

Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast

(2013) Shintaro Yamada et al.   NUCLEIC ACIDS RESEARCH

Characterization of Prdm9 in Equids and Sterility in Mules

(2013) Cynthia C. Steiner et al.   PLoS One

Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells

(2013) Bingnan Gu et al.   Cell and Bioscience

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

(2013) Hong Wu et al.   Cell Reports

Scale matters

(2012) Sam E. Tischfield et al.   CELL CYCLE

Genetic recombination is directed away from functional genomic elements in mice

(2012) Kevin Brick et al.   NATURE

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

(2012) Andrew H. Chan et al.   PLoS Genetics

Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle

(2012) Cynthia Sandor et al.   PLoS Genetics

ACT: aggregation and correlation toolbox for analyses of genome tracks

(2011) J. Jee et al.   BIOINFORMATICS

H3K4 tri-methylation provides an epigenetic signature of active enhancers

(2011) Aleksandra Pekowska et al.   EMBO JOURNAL

Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome

(2011) E. Axelsson et al.   GENOME RESEARCH

What are the genomic drivers of the rapid evolution of PRDM9?

(2011) Chris P. Ponting   TRENDS IN GENETICS

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination

(2011) Corinne Grey et al.   PLOS BIOLOGY

ZINBA integrates local covariates with DNA-seq data to identify broad and narrow regions of enrichment, even within amplified genomic regions

(2011) Naim U Rashid et al.   GENOME BIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

(2010) Ingrid L Berg et al.   NATURE GENETICS

Prdm9 Controls Activation of Mammalian Recombination Hotspots

(2010) E. D. Parvanov et al.   SCIENCE

Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

(2010) S. Myers et al.   SCIENCE

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

Processing the H3K36me3 signature

(2009) Robert J Sims III et al.   NATURE GENETICS