A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis

In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

(2017) Corinne Grey et al.   GENOME RESEARCH

PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis

(2017) Emil D. Parvanov et al.   MOLECULAR BIOLOGY OF THE CELL

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

(2017) Michaël Imbeault et al.   NATURE

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

(2017) Zachary Baker et al.   eLife

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair

(2016) Julian Lange et al.   CELL

The evolutionary turnover of recombination hot spots contributes to speciation in mice

(2016) Fatima Smagulova et al.   GENES & DEVELOPMENT

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice

(2016) Benjamin Davies et al.   NATURE

Health and population effects of rare gene knockouts in adult humans with related parents

(2016) V. M. Narasimhan et al.   SCIENCE

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

(2016) David Cano-Rodriguez et al.   Nature Communications

The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo

(2016) Natalie R. Powers et al.   PLoS Genetics

Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis

(2015) Fengyun Sun et al.   CHROMOSOMA

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses

(2015) Gernot Wolf et al.   GENES & DEVELOPMENT

DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination

(2015) Natasha Zamudio et al.   GENES & DEVELOPMENT

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Active promoters give rise to false positive ‘Phantom Peaks’ in ChIP-seq experiments

(2015) Dhawal Jain et al.   NUCLEIC ACIDS RESEARCH

The MEME Suite

(2015) Timothy L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage

(2015) Michael Walker et al.   Epigenetics & Chromatin

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

(2015) Christopher L. Baker et al.   PLoS Genetics

Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots

(2015) Christopher L. Baker et al.   PLoS Genetics

Setdb1is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells

(2014) Sheng Liu et al.   GENES & DEVELOPMENT

PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration

(2014) C. L. Baker et al.   GENOME RESEARCH

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

(2014) Mohammad S. Eram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

(2014) Frank M. J. Jacobs et al.   NATURE

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics

(2014) Francesca Cole et al.   NATURE GENETICS

Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-Containing Zinc Finger Proteins

(2014) Wei Wang et al.   PLoS One

Recombination initiation maps of individual human genomes

(2014) F. Pratto et al.   SCIENCE

Primate evolution of the recombination regulator PRDM9

(2014) Jerrod J. Schwartz et al.   Nature Communications

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

(2014) Yao-Cheng Lin et al.   Nature Communications

Common and low-frequency variants associated with genome-wide recombination rate

(2013) Augustine Kong et al.   NATURE GENETICS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

De novo prediction of DNA-binding specificities for Cys2His2 zinc finger proteins

(2013) Anton V. Persikov et al.   NUCLEIC ACIDS RESEARCH

ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature

(2013) R. W. J. Collin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of PRDM9

(2013) Hong Wu et al.   Cell Reports

A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code

(2013) Hirotaka Nakahashi et al.   Cell Reports

Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs

(2013) Adam Auton et al.   PLoS Genetics

DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis

(2013) Janet M. Young et al.   PLoS Genetics

DNA binding specificities of the long zinc-finger recombination protein PRDM9

(2013) Timothy Billings et al.   GENOME BIOLOGY

TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

(2012) H. M. Rowe et al.   GENOME RESEARCH

ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia

(2012) S. G. Landt et al.   GENOME RESEARCH

Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors

(2012) J. Wang et al.   GENOME RESEARCH

Genetic recombination is directed away from functional genomic elements in mice

(2012) Kevin Brick et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

A Fine-Scale Chimpanzee Genetic Map from Population Sequencing

(2012) A. Auton et al.   SCIENCE

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

(2012) Frank Sleutels et al.   Epigenetics & Chromatin

Interallelic and Intergenic Incompatibilities of the Prdm9 (Hst1) Gene in Mouse Hybrid Sterility

(2012) Petr Flachs et al.   PLoS Genetics

Functional Analysis of KAP1 Genomic Recruitment

(2011) S. Iyengar et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide analysis reveals novel molecular features of mouse recombination hotspots

(2011) Fatima Smagulova et al.   NATURE

The landscape of recombination in African Americans

(2011) Anjali G. Hinch et al.   NATURE

The Human Epigenome Browser at Washington University

(2011) Xin Zhou et al.   NATURE METHODS

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations

(2011) I. L. Berg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse PRDM9 DNA-Binding Specificity Determines Sites of Histone H3 Lysine 4 Trimethylation for Initiation of Meiotic Recombination

(2011) Corinne Grey et al.   PLOS BIOLOGY

The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

(2011) Laure Ségurel et al.   PLOS BIOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Stampy: A statistical algorithm for sensitive and fast mapping of Illumina sequence reads

(2010) G. Lunter et al.   GENOME RESEARCH

BORIS (CTCFL) Is Not Expressed in Most Human Breast Cell Lines and High Grade Breast Carcinomas

(2010) William C. Hines et al.   PLoS One

Prdm9 Controls Activation of Mammalian Recombination Hotspots

(2010) E. D. Parvanov et al.   SCIENCE

Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination

(2010) S. Myers et al.   SCIENCE

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

(2010) F. Baudat et al.   SCIENCE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Distinct histone modifications define initiation and repair of meiotic recombination in the mouse

(2009) Jérôme Buard et al.   EMBO JOURNAL

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Predicting DNA recognition by Cys2His2 zinc finger proteins

(2008) Anton V. Persikov et al.   BIOINFORMATICS

Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites

(2008) Valérie Borde et al.   EMBO JOURNAL

A common sequence motif associated with recombination hot spots and genome instability in humans

(2008) Simon Myers et al.   NATURE GENETICS

A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase

(2008) O. Mihola et al.   SCIENCE