Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

(2016) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice

(2016) Peter Lundbäck et al.   HEPATOLOGY

Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization

(2016) Ruili Huang et al.   Nature Communications

Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress

(2015) Fiona E. Mutter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney

(2015) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

Evidence That the Capacity of Nongenotoxic Carcinogens to Induce Oxidative Stress Is Subject to Marked Variability

(2015) Colin J. Henderson et al.   TOXICOLOGICAL SCIENCES

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment

(2014) Steven Wink et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

(2014) Joanne Walsh et al.   Journal of Proteomics

Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

(2014) Adam J Shuhendler et al.   NATURE BIOTECHNOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

A transgenic mouse model for monitoring oxidative stress

(2012) Daisuke Oikawa et al.   Scientific Reports

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

(2010) Neil R. Kitteringham et al.   Journal of Proteomics

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Differences in Immunolocalization of Kim-1, RPA-1, and RPA-2 in Kidneys of Gentamicin-, Cisplatin-, and Valproic Acid-Treated Rats: Potential Role of iNOS and Nitrotyrosine

(2009) Jun Zhang et al.   TOXICOLOGIC PATHOLOGY

Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

(2009) D.J. Antoine et al.   XENOBIOTICA

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

(2008) Ian M. Copple et al.   HEPATOLOGY