Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing

A Highly Efficient Synthetic Vector: Nonhydrodynamic Delivery of DNA to Hepatocyte Nuclei in Vivo

(2013) Yunxia Hu et al.   ACS Nano

Semiconducting Polymer Nanoprobe for In Vivo Imaging of Reactive Oxygen and Nitrogen Species

(2013) Kanyi Pu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Fluorescent Semiconducting Polymer Dots for Biology and Medicine

(2013) Changfeng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Stress and Neurodegenerative Disorders

(2013) Jie Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy

(2013) Feng Li et al.   NATURE MEDICINE

Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles

(2013) Ning Zhang et al.   NATURE MEDICINE

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Monitoring for Tuberculosis Drug Hepatotoxicity: Moving from Opinion to Evidence

(2012) Jussi J. Saukkonen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

(2012) Melanie Z. Sakatis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Direct Oxidation and Covalent Binding of Isoniazid to Rodent Liver and Human Hepatic Microsomes: Humans Are More Like Mice than Rats

(2012) Imir G. Metushi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Self-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging

(2012) Liqin Xiong et al.   Nature Communications

Chemical and Engineering Approaches To Enable Organic Field-Effect Transistors for Electronic Skin Applications

(2011) Anatoliy N. Sokolov et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hybrid Quantum Dot−Fatty Ester Stealth Nanoparticles: Toward Clinically Relevant in Vivo Optical Imaging of Deep Tissue

(2011) Adam J. Shuhendler et al.   ACS Nano

Unapproved drugs in the united states and the food and drug administration

(2011) Alexander Nasr et al.   ADVANCES IN THERAPY

Bioactivation of Drugs: Risk and Drug Design

(2011) John S. Walsh et al.   Annual Review of Pharmacology and Toxicology

A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity

(2011) I G Metushi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Real-time in vivo detection of biomaterial-induced reactive oxygen species

(2010) Wendy F. Liu et al.   BIOMATERIALS

Development and Application of a Near-Infrared Fluorescence Probe for Oxidative Stress Based on Differential Reactivity of Linked Cyanine Dyes

(2010) Daihi Oushiki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond

(2010) A. D. Maynard et al.   TOXICOLOGICAL SCIENCES

In vitro assessments of nanomaterial toxicity

(2009) Clinton F. Jones et al.   ADVANCED DRUG DELIVERY REVIEWS

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

(2009) Wei Tang et al.   DRUG METABOLISM REVIEWS

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Second window for in vivo imaging

(2009) Andrew M. Smith et al.   Nature Nanotechnology

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

(2008) Daniel J Antoine et al.   Expert Opinion on Drug Metabolism & Toxicology

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Toward a Biocompatible and Biodegradable Copolymer Incorporating Electroactive Oligothiophene Units

(2008) Nathalie K. E. Guimard et al.   MACROMOLECULES

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY