Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

Three-dimensional (3D) spheroid cultures improve the metabolic gene expression profiles of HepaRG cells

(2015) Yu Takahashi et al.   BIOSCIENCE REPORTS

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

(2015) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

Toward predictive models for drug-induced liver injury in humans: are we there yet?

(2014) Minjun Chen et al.   Biomarkers in Medicine

In vitro platforms for evaluating liver toxicity

(2014) Shyam Sundhar Bale et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

(2014) Joanne Walsh et al.   Journal of Proteomics

Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

(2013) K M Hillgren et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Oncogenic functions of the transcription factor Nrf2

(2013) Irene Gañán-Gómez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC–MS/MS method determines its turnover number and correlates with its glucuronidation activities

(2013) Beibei Xu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Identification of aldo-keto reductases as NRF2-target marker genes in human cells

(2013) Kyeong-Ah Jung et al.   TOXICOLOGY LETTERS

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

(2013) Abhinav Bhushan et al.   Stem Cell Research & Therapy

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

(2012) J. Fraczek et al.   ARCHIVES OF TOXICOLOGY

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Generation of proliferating human hepatocytes using upcyte®technology: characterisation and applications in induction and cytotoxicity assays

(2012) Alexandra Burkard et al.   XENOBIOTICA

Development of a multiplex UPLC-MRM MS method for quantification of human membrane transport proteins OATP1B1, OATP1B3 and OATP2B1 in in vitro systems and tissues

(2011) Chengjie Ji et al.   ANALYTICA CHIMICA ACTA

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

(2008) T. Ohta et al.   CANCER RESEARCH

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

(2008) Daniel J Antoine et al.   Expert Opinion on Drug Metabolism & Toxicology

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA