Mechanism-based bioanalysis and biomarkers for hepatic chemical stress

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superiority of serum type-I arginase and ornithine carbamyltransferase in the detection of toxicant-induced acute hepatic injury in rats

(2008) Hiroshi Murayama et al.   CLINICA CHIMICA ACTA

Ornithine carbamyltransferase is a sensitive marker for alcohol-induced liver injury

(2008) Hiroshi Murayama et al.   CLINICA CHIMICA ACTA

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide

(2008) Mary Jane Masson et al.   HEPATOLOGY

Cytochrome c: a non-invasive biomarker of drug-induced liver injury

(2008) T. J. Miller et al.   JOURNAL OF APPLIED TOXICOLOGY

Marked elevation of serum mitochondrion-derived markers in mild models of non-alcoholic steatohepatitis in rats

(2008) Hiroshi Murayama et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation

(2008) G-Z Tao et al.   JOURNAL OF PATHOLOGY

Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients

(2008) Shuji Goto et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

(2008) J. Cummings et al.   MOLECULAR CANCER THERAPEUTICS

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2+/− mice: Two-stage oxidative injury

(2008) Yie Hou Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biomarker method validation in anticancer drug development

(2007) J Cummings et al.   BRITISH JOURNAL OF PHARMACOLOGY

The current state of serum biomarkers of hepatotoxicity

(2007) Josef Ozer et al.   TOXICOLOGY