Plant derived inhibitors of NF-κB

Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition

(2012) Khadija Essafi-Benkhadir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NFκB activation in piceatannol-treated human leukemia U937 cells

(2012) Wen-Hsin Liu et al.   BIOCHEMICAL PHARMACOLOGY

The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration

(2012) Roberto Benelli et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and molecular docking studies of sinomenine derivatives

(2012) Xiaoyun Chai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway

(2012) Hiroki Goto et al.   CANCER SCIENCE

Natural Products Triggering Biological Targets- A Review of the Anti-Inflammatory Phytochemicals Targeting the Arachidonic Acid Pathway in Allergy Asthma and Rheumatoid Arthritis

(2012) Sophie Chen   CURRENT DRUG TARGETS

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Celebrating 25 years of NF-κB research

(2012) Sankar Ghosh et al.   IMMUNOLOGICAL REVIEWS

Sulfated Derivative of 20(S)-Ginsenoside Rh2 Inhibits Inflammatory Cytokines Through MAPKs and NF-kappa B Pathways in LPS-Induced RAW264.7 Macrophages

(2012) Wen-Yan Bi et al.   INFLAMMATION

Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway

(2012) Yuh-Lit Chow et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells

(2012) Hyun-Gyu Choi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways

(2012) Bilal Bin Hafeez et al.   INTERNATIONAL JOURNAL OF CANCER

Syk/Src Pathway-Targeted Inhibition of Skin Inflammatory Responses by Carnosic Acid

(2012) Jueun Oh et al.   MEDIATORS OF INFLAMMATION

Cryptopleurine Targets NF-κB Pathway, Leading to Inhibition of Gene Products Associated with Cell Survival, Proliferation, Invasion, and Angiogenesis

(2012) Hong Ri Jin et al.   PLoS One

β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway

(2011) Allisson Freire Bento et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities

(2011) Jeong Ah Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

RETRACTED: Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway

(2011) Byoungduck Park et al.   BIOCHEMICAL PHARMACOLOGY

Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-κB pathway

(2011) Ru-Huei Fu et al.   BIOTECHNOLOGY LETTERS

Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

(2011) Radhamani Kannaiyan et al.   BRITISH JOURNAL OF PHARMACOLOGY

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Phytochemicals suppress nuclear factor-κB signaling

(2011) Antero Salminen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Role of nuclear factor-κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents

(2011) Subash C Gupta et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1

(2011) Mee-Young Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells

(2011) Yue Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

(2011) Vivek Bhakta Mathema et al.   INFLAMMATION

Barrier protective effects of lycopene in human endothelial cells

(2011) Jae Woan Bae et al.   INFLAMMATION RESEARCH

Antioxidant and Anti-Inflammatory Potential of Hesperetin Metabolites Obtained from Hesperetin-Administered Rat Serum: An Ex Vivo Approach

(2011) Hsin-Ling Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytesin Vitro

(2011) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

(2011) Jan Hošek et al.   JOURNAL OF NATURAL PRODUCTS

Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells

(2011) J. Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Catechin Suppresses an Array of Signalling Molecules and Modulates Alcohol-Induced Endotoxin Mediated Liver Injury in a Rat Model

(2011) Sushma Bharrhan et al.   PLoS One

Apoptosis Inducing Effect of Plumbagin on Colonic Cancer Cells Depends on Expression of COX-2

(2011) Bharathi Raja Subramaniya et al.   PLoS One

DEDC, a new flavonoid induces apoptosis via a ROS-dependent mechanism in human neuroblastoma SH-SY5Y cells

(2011) Huibin Liu et al.   TOXICOLOGY IN VITRO

Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro

(2011) Wei Zhang et al.   TOXICOLOGY LETTERS

NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy

(2010) Ashutosh Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

(2010) Subash C. Gupta et al.   CANCER AND METASTASIS REVIEWS

Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NF-kappaB signaling pathways

(2010) Sahdeo Prasad et al.   CANCER BIOLOGY & THERAPY

Nuphar lutea thioalkaloids inhibit the nuclear factor κappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide

(2010) Janet Ozer et al.   CANCER BIOLOGY & THERAPY

Thiocolchicoside Exhibits Anticancer Effects through Downregulation of NF- B Pathway and Its Regulated Gene Products Linked to Inflammation and Cancer

(2010) S. Reuter et al.   Cancer Prevention Research

 -Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment

(2010) A. B. Kunnumakkara et al.   CANCER RESEARCH

Noscapine, a Benzylisoquinoline Alkaloid, Sensitizes Leukemic Cells to Chemotherapeutic Agents and Cytokines by Modulating the NF- B Signaling Pathway

(2010) B. Sung et al.   CANCER RESEARCH

Leishmania major: Anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-κB

(2010) Lital Ozer et al.   EXPERIMENTAL PARASITOLOGY

Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells

(2010) Chia-Chien Hsieh et al.   FOOD CHEMISTRY

Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway

(2010) Shobha Bhaskar et al.   IMMUNOBIOLOGY

Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation

(2010) Da-Hye Jung et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Crotepoxide Chemosensitizes Tumor Cells through Inhibition of Expression of Proliferation, Invasion, and Angiogenic Proteins Linked to Proinflammatory Pathway

(2010) Sahdeo Prasad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-κB signaling pathway in colon cancer cells

(2010) Zhengfeng Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cepharanthine Exerts Anti-Inflammatory Effects Via NF-κB Inhibition in a LPS-Induced Rat Model of Systemic Inflammation

(2010) Kyosuke Kudo et al.   JOURNAL OF SURGICAL RESEARCH

Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway

(2010) Chenghai Li et al.   Molecular Cancer

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

(2010) Kuzhuvelil B. Harikumar et al.   MOLECULAR CANCER RESEARCH

Embelin Suppresses Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand and Tumor CellsIn vitrothrough Inhibition of the NF-κB Cell Signaling Pathway

(2010) Simone Reuter et al.   MOLECULAR CANCER RESEARCH

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor- B Signaling Pathway

(2010) K. B. Harikumar et al.   MOLECULAR PHARMACOLOGY

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden

(2010) L Connelly et al.   ONCOGENE

Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin

(2010) Se-Jeong Park et al.   PHYTOCHEMISTRY

Dual mechanisms of NF-κB inhibition in carnosol-treated endothelial cells

(2010) Kai-Cheng Lian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells

(2010) Dong-Oh Moon et al.   TOXICOLOGY IN VITRO

Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells

(2009) Yun Liang et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of NF-κB by ginsenoside Rg3 enhances the susceptibility of colon cancer cells to docetaxel

(2009) Sun Mi Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells

(2009) Dong-Oh Moon et al.   CANCER LETTERS

Suppression of inducible nitric oxide synthase by (−)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-κB activity

(2009) Su-Hyun Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB–Regulated Gene Products and Potentiates Apoptosis

(2008) Preetha Anand et al.   CANCER RESEARCH

Inhibition of intestinal ischemia/repurfusion induced apoptosis and necrosis via down-regulation of the NF-kB, c-Jun and caspace-3 expression by epigallocatechin-3-gallate administration

(2008) Alexandros E. Giakoustidis et al.   FREE RADICAL RESEARCH