NF-κB addiction and its role in cancer: ‘one size does not fit all’

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

Hierarchical clustering of immunohistochemical analysis of the activated ErbB/PI3K/Akt/NF-κB signalling pathway and prognostic significance in prostate cancer

(2010) I H Koumakpayi et al.   BRITISH JOURNAL OF CANCER

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Requirement of the NF-κB Subunit p65/RelA for K-Ras–Induced Lung Tumorigenesis

(2010) Daniela S. Bassères et al.   CANCER RESEARCH

Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKKβ as a potential target

(2010) Pil-Soon Son et al.   CARCINOGENESIS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

NF-κB as a therapeutic target in chronic lymphocytic leukemia

(2010) Monica Lopez-Guerra et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

κB-Ras Is a Nuclear-Cytoplasmic Small GTPase That Inhibits NF-κB Activation through the Suppression of Transcriptional Activation of p65/RelA

(2010) Kenji Tago et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation

(2010) Chunyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex

(2010) Stepan Gambaryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional ablation of Ikkb inhibits melanoma tumor development in mice

(2010) Jinming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF- B

(2010) X. D. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

SUMOylation-Dependent Localization of IKKɛ in PML Nuclear Bodies Is Essential for Protection against DNA-Damage-Triggered Cell Death

(2010) Florian Renner et al.   MOLECULAR CELL

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Big science: The cancer genome challenge

(2010) Heidi Ledford   NATURE

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Turning Off Inflammation Signaling

(2010) S. Sriskantharajah et al.   SCIENCE

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

TGF-β downregulates PTEN via activation of NF-κB in pancreatic cancer cells

(2009) Jimmy Y. C. Chow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Biologic sequelae of I B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

(2009) T. Hideshima et al.   BLOOD

Bortezomib induces canonical nuclear factor- B activation in multiple myeloma cells

(2009) T. Hideshima et al.   BLOOD

MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor- B p65 Transcription Factor

(2009) R. Ahmad et al.   CANCER RESEARCH

Nuclear NF- B p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

(2009) P. Arun et al.   CLINICAL CANCER RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Inflammation and cancer: how friendly is the relationship for cancer patients?

(2009) Bharat B Aggarwal et al.   CURRENT OPINION IN PHARMACOLOGY

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Novel clinico–genome network modeling for revolutionizing genotype–phenotype-based personalized cancer care

(2009) Dimitrios H Roukos   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Diacylglycerol kinase α enhances protein kinase Cζ-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-κB

(2009) Masahiro Kai et al.   FEBS LETTERS

NF-κB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia

(2009) Chris Pepper et al.   Future Oncology

FoxO4 Inhibits NF-κB and Protects Mice Against Colonic Injury and Inflammation

(2009) Wen Zhou et al.   GASTROENTEROLOGY

GCN5 is a required cofactor for a ubiquitin ligase that targets NF- B/RelA

(2009) X. Mao et al.   GENES & DEVELOPMENT

Cleaved caspase-3 and nuclear factor-κB p65 are prognostic factors in metastatic serous ovarian carcinoma

(2009) Lilach Kleinberg et al.   HUMAN PATHOLOGY

High expression levels of IKKα and IKKβ are necessary for the malignant properties of liver cancer

(2009) Runqiu Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor Necrosis Factor-α Induces RelA Degradation via Ubiquitination at Lysine 195 to Prevent Excessive Nuclear Factor-κB Activation

(2009) Yihui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated by NFKB via PI3K/AKT signaling pathway

(2009) Hong-Zhi Sun et al.   JOURNAL OF ENDOCRINOLOGY

Respiratory Syncytial Virus Infection Induces a Reactive Oxygen Species-MSK1-Phospho-Ser-276 RelA Pathway Required for Cytokine Expression

(2009) M. Jamaluddin et al.   JOURNAL OF VIROLOGY

Small Cell Lung Cancer

(2009) Taimur Sher et al.   MAYO CLINIC PROCEEDINGS

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

(2009) Jessica E. Hutti et al.   MOLECULAR CELL

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

A small-cell lung cancer genome with complex signatures of tobacco exposure

(2009) Erin D. Pleasance et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY

Ser276 Phosphorylation of NF-kB p65 by MSK1 Controls SCF Expression in Inflammation

(2009) Laurent Reber et al.   PLoS One

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting mitogen-activated protein kinase kinase (MEK) in solid tumors

(2009) Austin Duffy et al.   Targeted Oncology

The NF-κB-independent functions of IKK subunits in immunity and cancer

(2009) Alain Chariot   TRENDS IN CELL BIOLOGY

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

(2009) Lars Vereecke et al.   TRENDS IN IMMUNOLOGY

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

NF- B as a Critical Link Between Inflammation and Cancer

(2009) M. Karin   Cold Spring Harbor Perspectives in Biology

Hyperoxia-induced NF-κB activation occurs via a maturationally sensitive atypical pathway

(2008) Clyde J. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

(2008) Jennifer Grosjean-Raillard et al.   APOPTOSIS

NIK and Cot cooperate to trigger NF-κB p65 phosphorylation

(2008) Tobias Wittwer et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic induction of nuclear factor-κB by transforming growth factor-β and tumour necrosis factor-α is mediated by protein kinase A-dependent RelA acetylation

(2008) Hajime Ishinaga et al.   BIOCHEMICAL JOURNAL

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor- B-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor- B  kinase, leading to potentiation of apoptosis

(2008) B. Sung et al.   BLOOD

HIF-1  regulates epithelial inflammation by cell autonomous NF B activation and paracrine stromal remodeling

(2008) M. Scortegagna et al.   BLOOD

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD

Contradictory functions of NF-κB in liver physiology and cancer

(2008) Gilad W. Vainer et al.   CANCER LETTERS

Berberine Modifies Cysteine 179 of I B  Kinase, Suppresses Nuclear Factor- B-Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

(2008) M. K. Pandey et al.   CANCER RESEARCH

Altered TAB1:I B Kinase Interaction Promotes Transforming Growth Factor  -Mediated Nuclear Factor- B Activation during Breast Cancer Progression

(2008) J. R. Neil et al.   CANCER RESEARCH

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 /  in Pancreatic Cancer

(2008) W. Wilson et al.   CANCER RESEARCH

Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB–Regulated Gene Products and Potentiates Apoptosis

(2008) Preetha Anand et al.   CANCER RESEARCH

SUMO1 modification of NF-κB2/p100 is essential for stimuli-induced p100 phosphorylation and processing

(2008) Jaya Vatsyayan et al.   EMBO REPORTS

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

(2008) Antero Salminen et al.   IMMUNOLOGY LETTERS

Activation of Syk by Protein Kinase C-δ Regulates Thrombin-induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Tyrosine Phosphorylation of RelA/p65

(2008) Kaiser M. Bijli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte Growth Factor Suppresses Proinflammatory NFκB Activation through GSK3β Inactivation in Renal Tubular Epithelial Cells

(2008) Rujun Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKIP1 Enhances NF-κB-dependent Gene Expression by Promoting the Nuclear Retention and Phosphorylation of p65

(2008) Nan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lymphotoxin-β Receptor Is an Upstream Activator of NF-κB-mediated Transcription in Melanoma Cells

(2008) Punita Dhawan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current and Future Utilization of Services From Medical Oncologists

(2008) Joan L. Warren et al.   JOURNAL OF CLINICAL ONCOLOGY

IRF-1 Is Required for Full NF- B Transcriptional Activity at the Human Immunodeficiency Virus Type 1 Long Terminal Repeat Enhancer

(2008) M. Sgarbanti et al.   JOURNAL OF VIROLOGY

The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

(2008) E Chapiro et al.   LEUKEMIA

Acquisition of Stable Inducible Up-Regulation of Nuclear Factor- B by Tumor Necrosis Factor Exposure Confers Increased Radiation Resistance without Increased Transformation in Breast Cancer Cells

(2008) S. Braunstein et al.   MOLECULAR CANCER RESEARCH

Targeting Nuclear Factor- B Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

(2008) G. Sethi et al.   MOLECULAR CANCER RESEARCH

UV as an Amplifier Rather Than Inducer of NF-κB Activity

(2008) Ellen L. O'Dea et al.   MOLECULAR CELL

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Copine-I represses NF-κB transcription by endoproteolysis of p65

(2008) C S Ramsey et al.   ONCOGENE

Dysregulated molecular networks in head and neck carcinogenesis

(2008) Alfredo A. Molinolo et al.   ORAL ONCOLOGY

Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

(2008) G. Lenz et al.   SCIENCE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Accumulation of phosphorylated IκBα and activated IKK in nodes of Ranvier

(2007) C. Politi et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY