Article
Chemistry, Multidisciplinary
Dan Li, Ying-ying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiao-feng Zeng, Qian Zeng, Man Xu, Qi-zhu Tang
Summary: The study shows that lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms by inhibiting the TLR4-PI3K-Akt-NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong
Summary: SRPK1 is overexpressed in colon cancer and correlated with clinical stage and TNM classifications. High levels of SRPK1 are associated with poor prognosis. Mechanistically, SRPK1 enhances the anti-apoptosis ability of colon cancer cells under oxaliplatin treatment by promoting NF-κB pathway activation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Xiaodong Yu, Tao Wu, Bo Liao, Zhongbo Du, Pingyu Zhu
Summary: Corilagin (CLG) possesses anti-tumor and anti-proliferative actions in bladder cancer cells by inhibiting cell viability, adhesion, movement, invasion, and inflammation, and inducing apoptosis. CLG also inhibits migration and invasion through the repression of NF-kappa B mediated P13K/Akt signaling pathways.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Ouadie Mohamed El Yaagoubi, Larbi Oularbi, Abdelhakim Bouyahya, Hamid Samaki, Said El Antri, Souad Aboudkhil
Summary: The Ubiquitin-Proteasome System is central in regulating NF-kappa B pathways in skin, with recent progress showing that inhibiting NF-kappa B activation by proteasome inhibitors can prevent the degradation of protein I kappa B and increase cancer cell sensitivity to apoptosis. This suggests that using proteasome inhibitors could be an effective strategy in treating skin cancer with constitutive activation of NF-kappa B.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Oncology
Lu Liu, Ying Wang, Chen Geng, Aihong Wang, Sai Han, Xuewu You, Yu Sun, Junhua Zhang, Wei Lu, Youzhong Zhang
Summary: The study found that the expression of CD155 gradually increases in cervical cancer, reducing CD155 expression can inhibit cell proliferation and tumor formation, while CD155 overexpression has the opposite effect. Interaction between CD155 and AKT forms a complex, activating the AKT/mTOR/NF-κB pathway and inhibiting autophagy and apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhang
Summary: Bupivacaine inhibits colorectal cancer proliferation by suppressing cell viability, promoting apoptosis and autophagy, regulating the NF-kappa B signaling pathway, demonstrating potential therapeutic effects.
Article
Oncology
Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang, Qing Yang
Summary: The study found that TRIM27 is elevated in RCC patients and closely correlated with poor prognosis. Functional studies showed that TRIM27 promotes cell proliferation and inhibits apoptosis in RCC. TRIM27's oncogenic role in RCC is mediated through the regulation of NF-kappa B signaling, making it a potential prognostic indicator and therapeutic target.
Article
Environmental Sciences
Laura O. Walter, Mariana F. Maioral, Lisandra O. Silva, Douglas B. Speer, Sanjay C. Campbell, Winklet Gallimore, Miriam B. Falkenberg, Maria Claudia Santos-Silva
Summary: This study evaluated the cytotoxicity of the o-quinone stypoldione isolated from brown algae on multiple myeloma cells (MM) and found it to have potential for MM treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Claudio Urbani, Alessandro Mattiello, Gianmarco Ferri, Francesco Raggi, Dania Russo, Giulia Marconcini, Daniele Cappellani, Luca Manetti, Claudio Marcocci, Francesco Cardarelli, Fausto Bogazzi
Summary: This study demonstrated that PCB153 reduces apoptosis in pituitary cells through activation of the PI3K/Akt-mediated NF-κB pathway, while also inhibiting the expression of pro-apoptotic proteins like p38-MAPK, P53, and P21.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Immunology
Tarun Minocha, Megha Das, Vipin Rai, Sumit Singh Verma, Nikee Awasthee, Subash Chandra Gupta, Chandana Haldar, Sanjeev Kumar Yadav
Summary: Melatonin exhibits dose-dependent anti-tumor effects on cervical cancer cells by inducing apoptosis, modulating cell cycle, and downregulating pro-inflammatory genes.
INFLAMMOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Sabrina Bossio, Anna Perri, Rocco Malivindi, Francesca Giordano, Vittoria Rago, Maria Mirabelli, Alessandro Salatino, Antonio Brunetti, Emanuela Alessandra Greco, Antonio Aversa
Summary: Recent studies have shown that oleuropein (OLE) found in olive leaf extract can inhibit tumor cell proliferation and reduce the invasiveness of cancer cells. It achieves this by modulating cell-cycle regulators, promoting apoptosis, and inhibiting cell migration and motility. However, further research is needed to understand the specific mechanisms involved, especially in seminoma cells.
Article
Oncology
Shixin Chan, Rui Sun, Xucan Tu, Manyu Guo, Qianqian Yuan, Zhen Yu, Zhenglin Wang, Shaocheng Hong, Wei Han, Bingbing Zou, Zeng Li, Huabing Zhang, Wei Chen
Summary: The study demonstrates that rutaecarpine (RUT) can inhibit the proliferation and migration of colorectal cancer cells and induce cell apoptosis by inactivating NF-kappa B/STAT3 signaling pathway. This suggests the potential clinical application of RUT for the treatment of colorectal cancer.
Article
Biochemistry & Molecular Biology
Esha Madan, Taylor M. Parker, Matthias R. Bauer, Alisha Dhiman, Christopher J. Pelham, Masaki Nagane, M. Lakshmi Kuppusamy, Matti Holmes, Thomas R. Holmes, Kranti Shaik, Kevin Shee, Salome Kiparoidze, Sean D. Smith, Yu-Soon A. Park, Jennifer J. Gomm, Louise J. Jones, Ana R. Tomas, Ana C. Cunha, Karuppaiyah Selvendiran, Laura A. Hansen, Alan R. Fersht, Kalman Hideg, Rajan Gogna, Periannan Kuppusamy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Jasmine George, Minakshi Nihal, Chandra K. Singh, Nihal Ahmad
MOLECULAR CARCINOGENESIS
(2019)
Article
Multidisciplinary Sciences
Esha Madan, Christopher J. Pelham, Masaki Nagane, Taylor M. Parker, Rita Canas-Marques, Kimberly Fazio, Kranti Shaik, Youzhong Yuan, Vanessa Henriques, Antonio Galzerano, Tadashi Yamashita, Miguel Alexandre Ferreira Pinto, Antonio M. Palma, Denise Camacho, Ana Vieira, David Soldini, Harikrishna Nakshatri, Steven R. Post, Christa Rhiner, Hiroko Yamashita, Davide Accardi, Laura A. Hansen, Carlos Carvalho, Antonio L. Beltran, Periannan Kuppusamy, Rajan Gogna, Eduardo Moreno
Review
Oncology
Christopher J. Pelham, Masaki Nagane, Esha Madan
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Esha Madan, Taylor M. Parker, Christopher J. Pelham, Antonio M. Palma, Maria L. Peixoto, Masaki Nagane, Aliya Chandaria, Ana R. Tomas, Rita Canas-Marques, Vanessa Henriques, Antonio Galzerano, Joaquim Cabral-Teixeira, Karuppaiyah Selvendiran, Periannan Kuppusamy, Carlos Carvalho, Antonio Beltran, Eduardo Moreno, Uttam K. Pati, Rajan Gogna
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Changliang Chen, Prachi Gupta, Deepak Parashar, Gopakumar G. Nair, Jasmine George, Anjali Geethadevi, Wei Wang, Shirng-Wern Tsaih, William Bradley, Ramani Ramchandran, Janet S. Rader, Pradeep Chaluvally-Raghavan, Sunila Pradeep
Article
Cell Biology
Deepak Parashar, Anjali Geethadevi, Miriam Ragle Aure, Jyotsna Mishra, Jasmine George, Changliang Chen, Manoj K. Mishra, Andliena Tahiri, Wei Zhao, Bindu Nair, Yiling Lu, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Amadou K. S. Camara, Mingyu Liang, Janet S. Rader, Ramani Ramchandran, Ming You, Anil K. Sood, Vessela N. Kristensen, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Article
Oncology
Deepak Parashar, Bindu Nair, Anjali Geethadevi, Jasmine George, Ajay Nair, Shirng-Wern Tsaih, Ishaque P. Kadamberi, Gopa Kumar Gopinadhan Nair, Yiling Lu, Ramani Ramchandran, Denise S. Uyar, Janet S. Rader, Prahlad T. Ram, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Review
Cell Biology
Esha Madan, Maria Leonor Peixoto, Peter Dimitrion, Timothy D. Eubank, Michail Yekelchyk, Sarmistha Talukdar, Paul B. Fisher, Qing-Sheng Mi, Eduardo Moreno, Rajan Gogna
TRENDS IN CELL BIOLOGY
(2020)
Article
Oncology
Chandra K. Singh, Jasmine George, Gagan Chhabra, Minakshi Nihal, Hao Chang, Nihal Ahmad
Summary: The study confirmed the pro-proliferative function of SIRT3 in melanocytic cells and identified potential metabolic regulatory mechanisms, including the impact on glucose and glycogen metabolism. The results indicate that SIRT3 inhibition affects cellular metabolism, leading to an anti-proliferative response against melanoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Anjali Geethadevi, Ajay Nair, Deepak Parashar, Zhiqiang Ku, Wei Xiong, Hui Deng, Yongsheng Li, Jasmine George, Donna M. McAllister, Yunguang Sun, Ishaque P. Kadamberi, Prachi Gupta, Michael B. Dwinell, William H. Bradley, Janet S. Rader, Hallgeir Rui, Robert F. Schwabe, Ningyan Zhang, Sunila Pradeep, Zhiqiang An, Pradeep Chaluvally-Raghavan
Summary: This study reveals that elevated OSMR in ovarian cancer promotes cancer cell proliferation and metastasis through STAT3 signaling activation, and demonstrates the potential efficacy of antibody targeting OSMR for ovarian cancer treatment.
Article
Cell Biology
Jasmine George, Yongsheng Li, Ishaque P. Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S. Rader, Anil K. Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Summary: The FXR1 gene is highly amplified in patients with ovarian cancer, leading to increased expression of FXR1 mRNA and protein. FXR1 enhances overall translation in cancer cells and stabilizes cMYC expression by binding to AU-rich elements within cMYC's 3' untranslated region. Additionally, FXR1's interactions with eIF4A1 and eIF4E proteins facilitate the recruitment of translation initiation factors to promote cMYC levels in cancer cells.
Article
Oncology
Deepak Parashar, Anjali Geethadevi, Sonam Mittal, Lindsey A. McAlarnen, Jasmine George, Ishaque P. Kadamberi, Prachi Gupta, Denise S. Uyar, Elizabeth E. Hopp, Holli Drendel, Erin A. Bishop, William H. Bradley, Kathleen M. Bone, Janet S. Rader, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Summary: Epithelial ovarian cancer (EOC) is a fatal gynecological cancer with high chemoresistance and recurrence. Malignant ascites, a fluid in the abdomen, is considered a major source of chemoresistance and poor survival in EOC patients. This study established an ovarian cancer cell line and found that 3D spheroids development and platinum-resistant phenotype are related to aberrant PI3K-AKT signaling. Combining cisplatin with a PI3K-AKT inhibitor sensitized the cells to cisplatin. These findings provide evidence for advancing therapeutic approaches for cisplatin resistance in EOC patients.
Article
Chemistry, Multidisciplinary
Prachi Gupta, Ishaque Pulikkal Kadamberi, Sonam Mittal, Shirng-Wern Tsaih, Jasmine George, Sudhir Kumar, Dileep K. Vijayan, Anjali Geethadevi, Deepak Parashar, Paytsar Topchyan, Lindsey McAlarnen, Brian F. Volkman, Weiguo Cui, Kam Y. J. Zhang, Dolores Di Vizio, Pradeep Chaluvally-Raghavan, Sunila Pradeep
Summary: SPHK1-packaged EVs increase S1P levels in the tumor microenvironment, leading to immunosuppression and promoting ovarian cancer progression. Inhibiting SPHK1/S1P signaling may enhance the efficacy of immune checkpoint blockade therapy in ovarian cancer.
Article
Biochemical Research Methods
Jasmine George, Sonam Mittal, Ishaque P. Kadamberi, Sunila Pradeep, Pradeep Chaluvally-Raghavan
Summary: In this study, a reliable and sensitive approach was developed to address the target specificity issues of conventional proximity ligation assay (PLA) in interpreting proximal interactions in cell biology. By including a fluorochrome-labeled mRNA fragment, a biotin-labeled RNA probe, and a target-specific antibody, proximity ligation signals were generated through linear connectors in intact cells. This protocol is particularly useful for studying proximal interactions between RNA binding proteins (RBPs) and their target mRNAs.