Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells

Celastrol Attenuates Hypertension-Induced Inflammation and Oxidative Stress in Vascular Smooth Muscle Cells via Induction of Heme Oxygenase-1

(2010) X. Yu et al.   AMERICAN JOURNAL OF HYPERTENSION

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy

(2010) Feng Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells

(2010) Feng Li et al.   CANCER LETTERS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Targeting apoptosis pathways in cancer by Chinese medicine

(2010) Min Li-Weber   CANCER LETTERS

Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway

(2010) X. Pang et al.   CANCER RESEARCH

Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way

(2010) Denghai Zhang et al.   CELL STRESS & CHAPERONES

The Current Status and Future of Multiple Myeloma in the Clinic

(2010) Sundar Jagannath et al.   Clinical Lymphoma Myeloma & Leukemia

Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor

(2010) Vivek R. Yadav et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

(2010) Daniel Paris et al.   Journal of Neuroinflammation

NF-κB localization in multiple myeloma plasma cells and mesenchymal cells

(2010) Concetta Conticello et al.   LEUKEMIA RESEARCH

Dual Inhibition of Akt/Mammalian Target of Rapamycin Pathway byNanoparticle Albumin-Bound–Rapamycin and Perifosine Induces Antitumor Activity in Multiple Myeloma

(2010) Diana Cirstea et al.   MOLECULAR CANCER THERAPEUTICS

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

(2009) Heehyoung Lee et al.   CANCER CELL

Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line

(2009) Karnati R. Roy et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Synergistic Anti-Cancer Activity by the Combination of TRAIL/APO-2L and Celastrol

(2009) Hong Zhu et al.   CANCER INVESTIGATION

Celastrol, a novel HSP90 inhibitor, depletes Bcr–Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation

(2009) Zhongzheng Lu et al.   CANCER LETTERS

Repression of NHE1 Expression by PPAR  Activation Is a Potential New Approach for Specific Inhibition of the Growth of Tumor Cells In vitro and In vivo

(2009) A. P. Kumar et al.   CANCER RESEARCH

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

(2009) B. B. Aggarwal et al.   CLINICAL CANCER RESEARCH

Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate Cancer

(2009) Yao Dai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Multiple myeloma

(2009) Marc S Raab et al.   LANCET

Proteasome inhibitors in the treatment of multiple myeloma

(2009) J J Shah et al.   LEUKEMIA

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

(2009) B. Sung et al.   MOLECULAR CANCER THERAPEUTICS

Potential pharmacological control of the NF-κB pathway

(2009) Gautam Sethi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IκBα kinase activation

(2008) Gautam Sethi et al.   BIOCHEMICAL PHARMACOLOGY

Multiple myeloma

(2008) R. A. Kyle et al.   BLOOD

Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

(2008) Yulun Huang et al.   CANCER LETTERS

Targeting STAT3 in cancer: how successful are we?

(2008) Peibin Yue et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Antimitotic quinoid triterpenes from Maytenus chuchuhuasca

(2007) Hiroshi Morita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS