Review
Cell Biology
Valerie Lannoy, Anthony Cote-Biron, Claude Asselin, Nathalie Rivard
Summary: Phosphatases are important regulators of TLRs signaling and may represent novel therapeutic targets to control pathogenic TLRs signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Article
Immunology
Hisatake Matsumoto, Brendon P. Scicluna, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gurkan, Erik Malmstrom, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van 't Veer, Tom van der Poll
Summary: The study indicates that HIVEP1 acts as a negative regulator of NF-κB in monocytes, inhibiting the proinflammatory response induced by bacterial agonists. Dysregulation of HIVEP1 leads to significant changes in the monocyte transcriptome and modulation of NF-κB responsive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Juan Felipe Valdes-Lopez, Geysson J. Fernandez, Silvio Urcuqui-Inchima
Summary: The study reveals that CHIKV infection induces high levels of IL27 in MDMs, promoting pro-inflammatory and antiviral response through activation of TLR1/2-MyD88 and TLR3-TRIF signaling pathways, independent of IFN signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Domenico Somma, Fatma O. Kok, David Kerrigan, Christine A. Wells, Ruaidhri J. Carmody
Summary: NF-kappa B is a crucial regulator of immune response, playing important roles in immune development, inflammation, and disease. Loss of function mutations in the NFKB1 gene are the most common monogenic cause of common variable immunodeficiencies in Europeans. By using CRISPR/Cas9 gene editing, researchers have generated a model of NFKB1(-/-) human macrophages, which exhibit pro-inflammatory characteristics and reduced expression of co-stimulatory factors important for adaptive immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Atsushi Kurata, Shogo Kiyohara, Tomoya Imai, Shino Yamasaki-Yashiki, Nobuhiro Zaima, Tatsuya Moriyama, Noriaki Kishimoto, Koichi Uegaki
Summary: We investigated the characteristics and functionalities of Lactiplantibacillus plantarum extracellular vesicles (EVs) towards host immune cells and found that these EVs activate both innate and acquired immune responses. Additionally, we discovered a significant amount of EVs in the rat gastrointestinal tract, suggesting their role as modulators of intestinal immunity.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Sairong Fan, Yanxing Wang, Yue Zhang, Yamin Wu, Xiaoming Chen
Summary: Achyranthes bidentata Blume polysaccharide (ABPS) has immunomodulatory activities through stimulating the NF-kappa B pathway via TLR4/MyD88 signaling, resulting in increased secretion of cytokines IL-1 beta and TNF-alpha.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Irene Veneziani, Claudia Alicata, Lorenzo Moretta, Enrico Maggi
Summary: Toll-like receptors (TLRs) are described as homo- or heterodimeric proteins mainly in antigen presenting cells like dendritic cells (DCs), but recent studies have discovered their expression and role also in natural killer (NK) cells. The activation and function of TLRs can be modulated directly or indirectly by TLR agonists. The interplay between DCs and NK cells, mediated by cell-to-cell contact and soluble factors, promotes DC maturation and NK cell activation. Based on this concept, TLR-based immunotherapy targeting the NK-DC axis has been proposed to modulate the tumor microenvironment, improve DC antigen presentation, and enhance NK cell cytotoxicity against tumor cells.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Mi-Jeong Kim, Ji Young Kim, Ji Hye Shin, Yeeun Kang, Ji Su Lee, Juhee Son, Soo-Kyung Jeong, Daesik Kim, Duk-Hwan Kim, Eunyoung Chun, Ki-Young Lee
Summary: This study investigates the crosstalk between FFARs and TLRs in lung cancer progression. The results show that FFAR2 is down-regulated in lung cancer and negatively correlated with TLR2 and TLR3. Functionally, stimulation of FFAR2 inhibits migration, invasion, and colony formation induced by TLR2 and TLR3 through the cAMP-AMPK-TAK1 signaling axis. Thus, FFAR2 agonists might be potential therapeutic agents for lung cancer.
CELL AND BIOSCIENCE
(2023)
Article
Veterinary Sciences
Manman Li, Guicong Lu, Xiao Ma, Ruihong Wang, Xihong Chen, Yongxiong Yu, Caode Jiang
Summary: Isoliquiritigenin (ISL) can inhibit oxidation and inflammation in bovine mammary epithelial cells. The anti-inflammatory and antioxidative activity of ISL involves the NF-kappa B and MAPK cascades.
BMC VETERINARY RESEARCH
(2022)
Article
Cell Biology
Jie Yang, Jiawen Yang, Xiaofang Huang, Huiqing Xiu, Songjie Bai, Jiahui Li, Zhijian Cai, Zhanghui Chen, Shufang Zhang, Gensheng Zhang
Summary: Glibenclamide alleviates the development of LPS-induced acute lung injury in a mouse model by inhibiting the NLRP3/Caspase-1/IL-1β signaling pathway.
MEDIATORS OF INFLAMMATION
(2022)
Article
Chemistry, Multidisciplinary
Yu Chen, Xiao Xiao Wang, Corrie H. C. Ng, Sai Wah Tsao, Wai Keung Leung
Summary: Transcripts and proteins of TLR1/2/4/5/6, NOD1/2 and NLRP1/2 were expressed in human periodontal tissue in health and disease, with NOD2 possibly considered as a key damage-associated molecular pattern sensor on periodontal resident cells.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Yanyun Hao, Hui Li, Xiaoyan Ge, Yang Liu, Xia Li, Yutong Liu, Hongfei Chen, Shiying Zhang, Jing Zou, Lingling Huang, Fabao Zhao, Dongwei Kang, Bruno G. De Geest, Zhiyue Zhang
Summary: In this study, a polymeric nano-immunomodulator was developed to selectively activate the immune system in tumors, enhancing T lymphocyte infiltration without causing immune-related adverse effects. It shows promising potential for safe systemic targeting delivery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Armando Moreno-Velasco, Mabel Fragoso-Serrano, Pedro de Jesus Flores-Tafoya, Sebastian Carrillo-Rojas, Elihu Bautista, Suzana Guimara Leitao, Jhon F. Castaneda-Gomez, Rogelio Pereda-Miranda
Summary: This study investigated the roots of Operculina hamiltonii, a traditional medicinal plant in Brazil. Three new acyl sugars or resin glycosides were identified and their structures elucidated. The combination of these compounds with other drugs showed enhanced cytotoxic effects on breast cancer cells.
Article
Biochemistry & Molecular Biology
Qian-Qing Liu, Lin-An Xiong, Jia-Yu Qian, Ting-Ting Gong, Lie-Feng Ma, Luo Fang, Zha-Jun Zhan
Summary: A new naturally occurring compound, Linderagatins C-F (1-4), with the structures of diaryltetrahydrofuran-type 7,9'-dinorlignans, was discovered in the roots of Lindera aggregata. The neuroprotective effects of compounds 2 and 3 on erastin-induced ferroptosis in HT-22 cells were found to be significant.