标题
hERG K+ Channels: Structure, Function, and Clinical Significance
作者
关键词
-
出版物
PHYSIOLOGICAL REVIEWS
Volume 92, Issue 3, Pages 1393-1478
出版商
American Physiological Society
发表日期
2012-07-19
DOI
10.1152/physrev.00036.2011
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Astemizole: an Old Anti-histamine as a New Promising Anti-cancer Drug
- (2012) Janice Garcia-Quiroz et al. Anti-Cancer Agents in Medicinal Chemistry
- Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide
- (2012) Rainer Schimpf et al. HEART RHYTHM
- Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective
- (2012) Katja E. Odening et al. HEART RHYTHM
- Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating
- (2012) Vassiliy N Bavro et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum
- (2012) Ying Wang et al. PLoS One
- Sex-Steroid Hormones and Electrocardiographic QT-Interval Duration: Findings From the Third National Health and Nutrition Examination Survey and the Multi-Ethnic Study of Atherosclerosis
- (2011) Yiyi Zhang et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- hERGCentral: A Large Database to Store, Retrieve, and Analyze Compound-Human Ether-à-go-go Related Gene Channel Interactions to Facilitate Cardiotoxicity Assessment in Drug Development
- (2011) Fang Du et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform
- (2011) C.Y. Du et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Computer Simulations of Structure–Activity Relationships for hERG Channel Blockers
- (2011) Lars Boukharta et al. BIOCHEMISTRY
- The hERG K+ channel S4 domain L532P mutation: Characterization at 37°C
- (2011) Yi H. Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Blockade of Permeation by Potassium but Normal Gating of the G628S Nonconducting hERG Channel Mutant
- (2011) Zeineb Es-Salah-Lamoureux et al. BIOPHYSICAL JOURNAL
- The role of Eag and HERG channels in cell proliferation and apoptotic cell death in SK-OV-3 ovarian cancer cell line
- (2011) Viren Asher et al. Cancer Cell International
- Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk
- (2011) Gary R. Mirams et al. CARDIOVASCULAR RESEARCH
- Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium
- (2011) Matthew R. Whorton et al. CELL
- Optical Action Potential Screening on Adult Ventricular Myocytes as an Alternative QT-screen
- (2011) Qinghai Tian et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- A Comprehensive Support Vector Machine Binary hERG Classification Model Based on Extensive but Biased End Point hERG Data Sets
- (2011) Meng-yu Shen et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of I Kr Inhibition on Ventricular Repolarization
- (2011) Lin Wu et al. CIRCULATION
- Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis
- (2011) Silvia G. Priori et al. CIRCULATION RESEARCH
- Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues
- (2011) Alan P. Benson et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Nonsense-mediated mRNA decay caused by a frameshift mutation in a large kindred of type 2 long QT syndrome
- (2011) Ignatius Gerardo Zarraga et al. HEART RHYTHM
- Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal
- (2011) Robert R. Fougere et al. HEART RHYTHM
- Protein Kinase A Activity at the Endoplasmic Reticulum Surface Is Responsible for Augmentation of Humanether-a-go-go-related Gene Product (HERG)
- (2011) Jakub Sroubek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells
- (2011) David Crottès et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Demonstration of Physical Proximity between the N Terminus and the S4-S5 Linker of the Humanether-à-go-go-related Gene (hERG) Potassium Channel
- (2011) Pilar de la Peña et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant HumanEther-á-go-go-related Gene Potassium Channels
- (2011) Elena C. Gianulis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis
- (2011) C.Y. DU et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- A Multiscale Simulation System for the Prediction of Drug-Induced Cardiotoxicity
- (2011) Cristian Obiol-Pardo et al. Journal of Chemical Information and Modeling
- Combined Receptor and Ligand-Based Approach to the Universal Pharmacophore Model Development for Studies of Drug Blockade to the hERG1 Pore Domain
- (2011) Serdar Durdagi et al. Journal of Chemical Information and Modeling
- hERG potassium channel gating is mediated by N- and C-terminal region interactions
- (2011) Ahleah S. Gustina et al. JOURNAL OF GENERAL PHYSIOLOGY
- Synergic Effects of β-Estradiol and Erythromycin on hERG Currents
- (2011) Fumiaki Ando et al. JOURNAL OF MEMBRANE BIOLOGY
- Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1
- (2011) Maxime Albesa et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
- (2011) Scott B. Hansen et al. NATURE
- The crystal structure of a voltage-gated sodium channel
- (2011) Jian Payandeh et al. NATURE
- The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation
- (2011) Chai Ann Ng et al. PLoS One
- Arsenic trioxide induces the apoptosis of human breast cancer MCF-7 cells through activation of caspase-3 and inhibition of HERG channels
- (2011) YING WANG et al. Experimental and Therapeutic Medicine
- Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome
- (2011) Ismail Adeniran et al. PLoS Computational Biology
- Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
- (2011) Thomas O'Hara et al. PLoS Computational Biology
- Ceramide modulates HERG potassium channel gating by translocation into lipid rafts
- (2010) Sindura B. Ganapathi et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Pore mutants of HERG and KvLQT1 downregulate the reciprocal currents in stable cell lines
- (2010) Xiao-Qin Ren et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Regulation of the voltage-insensitive step of HERG activation by extracellular pH
- (2010) Qinlian Zhou et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Multiple splicing defects caused by hERG splice site mutation 2592+1G>A associated with long QT syndrome
- (2010) Matthew R. Stump et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Down-regulation of the Human Ether-a-go-go-Related Gene in Rat Cardiac Hypertrophy
- (2010) Chuangjia Hu et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Comparison of Human Ether-à-go-go Related Gene Screening Assays Based on IonWorks Quattro and Thallium Flux
- (2010) Terry R. Bridal et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting
- (2010) Xi-Ping Huang et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- A Pharmacologically Validated, High-Capacity, Functional Thallium Flux Assay for the Human Ether-à-go-go Related Gene Potassium Channel
- (2010) William A. Schmalhofer et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- NMR solution structure of the N-terminal domain of hERG and its interaction with the S4–S5 linker
- (2010) Qingxin Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NMD: RNA biology meets human genetic medicine
- (2010) Madhuri Bhuvanagiri et al. BIOCHEMICAL JOURNAL
- Mutations within the S4–S5 Linker Alter Voltage Sensor Constraints in hERG K+ Channels
- (2010) Aaron C. Van Slyke et al. BIOPHYSICAL JOURNAL
- Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels
- (2010) AP Larsen et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effects of β-adrenoceptor stimulation on delayed rectifier K+ currents in canine ventricular cardiomyocytes
- (2010) G Harmati et al. BRITISH JOURNAL OF PHARMACOLOGY
- Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation.
- (2010) Brad Barrows et al. Channels
- Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy
- (2010) Naomi Gronich et al. Channels
- Toward a Consensus Model of the hERG Potassium Channel
- (2010) Anna Stary et al. ChemMedChem
- The hERG Potassium Channel and Drug Trapping: Insight from Docking Studies with Propafenone Derivatives
- (2010) Khac-Minh Thai et al. ChemMedChem
- Extracellular K + Is a Prerequisite for the Function and Plasma Membrane Stability of HERG Channels
- (2010) Hamid Massaeli et al. CIRCULATION RESEARCH
- The Role of the Funny Current in Pacemaker Activity
- (2010) Dario DiFrancesco CIRCULATION RESEARCH
- Reciprocal Control of hERG Stability by Hsp70 and Hsc70 With Implication for Restoration of LQT2 Mutant Stability
- (2010) Peili Li et al. CIRCULATION RESEARCH
- Short QT Syndrome: From Bench to Bedside
- (2010) Chinmay Patel et al. Circulation-Arrhythmia and Electrophysiology
- Utility of Treadmill Testing in Identification and Genotype Prediction in Long-QT Syndrome
- (2010) Jorge A. Wong et al. Circulation-Arrhythmia and Electrophysiology
- The Eag potassium channel as a new prognostic marker in ovarian cancer
- (2010) Viren Asher et al. Diagnostic Pathology
- The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism
- (2010) Guido Gessner et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles
- (2010) Kenshi Hayashi et al. HEART RHYTHM
- Trigger-specific risk factors and response to therapy in long QT syndrome type 2
- (2010) James A. Kim et al. HEART RHYTHM
- The Role of Monoubiquitination in Endocytic Degradation of Human Ether-a-go-go-related Gene (hERG) Channels under Low K+Conditions
- (2010) Tao Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain
- (2010) Frederick W. Muskett et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Involvement of Caveolin in Low K+-induced Endocytic Degradation of Cell-surface Human Ether-a-go-go-related Gene (hERG) Channels
- (2010) Hamid Massaeli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation
- (2010) CHUN YUN DU et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- In Silico Binary Classification QSAR Models Based on 4D-Fingerprints and MOE Descriptors for Prediction of hERG Blockage
- (2010) Bo-Han Su et al. Journal of Chemical Information and Modeling
- Modulation of cardiac ERG1 K+ channels by cGMP signaling
- (2010) Marco Mewe et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts
- (2010) Nathalie Gaborit et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A KCR1 variant implicated in susceptibility to the long QT syndrome
- (2010) Kenshi Hayashi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A novel mutation in the KCNH2 gene associated with short QT syndrome
- (2010) Yaxun Sun et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers
- (2010) Matthew Perry et al. JOURNAL OF PHYSIOLOGY-LONDON
- Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels
- (2010) Katrin Kolbe et al. JOURNAL OF PHYSIOLOGY-LONDON
- The Response of the QT Interval to the Brief Tachycardia Provoked by Standing
- (2010) Sami Viskin et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Polymorphisms in the NOS1APGene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome
- (2010) Marta Tomás et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Post-Transcriptional Control of Human Ether-a-go-go-Related Gene Potassium Channel Protein by -Adrenergic Receptor Stimulation
- (2010) J. Chen et al. MOLECULAR PHARMACOLOGY
- Molecular Determinants of Human ether-a-go-go-Related Gene 1 (hERG1) K+ Channel Activation by NS1643
- (2010) M. Grunnet et al. MOLECULAR PHARMACOLOGY
- Structural mechanism of C-type inactivation in K+ channels
- (2010) Luis G. Cuello et al. NATURE
- Structural basis for the coupling between activation and inactivation gates in K+ channels
- (2010) Luis G. Cuello et al. NATURE
- The mechanism of eukaryotic translation initiation and principles of its regulation
- (2010) Richard J. Jackson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mapping the sequence of conformational changes underlying selectivity filter gating in the Kv11.1 potassium channel
- (2010) David T Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Role of the ubiquitin system in regulating ion transport
- (2010) Daniela Rotin et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Multifarious molecular signaling cascades of cardiac hypertrophy: Can the muddy waters be cleared?☆
- (2010) Pitchai Balakumar et al. PHARMACOLOGICAL RESEARCH
- Drug-Induced Long QT Syndrome
- (2010) P. Kannankeril et al. PHARMACOLOGICAL REVIEWS
- Fluorescence-Tracking of Activation Gating in Human ERG Channels Reveals Rapid S4 Movement and Slow Pore Opening
- (2010) Zeineb Es-Salah-Lamoureux et al. PLoS One
- Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations
- (2010) Julia Subbotina et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Termination of drug-induced torsades de pointes with overdrive pacing
- (2009) Nathan P. Charlton et al. AMERICAN JOURNAL OF EMERGENCY MEDICINE
- PKA phosphorylation of HERG protein regulates the rate of channel synthesis
- (2009) Jian Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel
- (2009) Steven A. Titus et al. ANALYTICAL BIOCHEMISTRY
- Inhibition of the HERG Channel by Droperidol Depends on Channel Gating and Involves the S6 Residue F656
- (2009) Tao Luo et al. ANESTHESIA AND ANALGESIA
- hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome
- (2009) M.J. McPate et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hypoxia inhibits maturation and trafficking of hERG K + channel protein: Role of Hsp90 and ROS
- (2009) Jayasri Nanduri et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Electrophysiologic characterization of a novel hERG channel activator
- (2009) Zhi Su et al. BIOCHEMICAL PHARMACOLOGY
- Interactions of H562 in the S5 Helix with T618 and S621 in the Pore Helix Are Important Determinants of hERG1 Potassium Channel Structure and Function
- (2009) James P. Lees-Miller et al. BIOPHYSICAL JOURNAL
- Reverse rate dependency is an intrinsic property of canine cardiac preparations
- (2009) Tamás Bányász et al. CARDIOVASCULAR RESEARCH
- Regulation of HERG (KCNH2) potassium channel surface expression by diacylglycerol
- (2009) Cia Ramström et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration
- (2009) Emad Afrasiabi et al. CELLULAR SIGNALLING
- Is there a significant transmural gradient in repolarization time in the intact heart?
- (2009) Tobias Opthof et al. Circulation-Arrhythmia and Electrophysiology
- How do ER export motifs work on ion channel trafficking?
- (2009) Melanie Mikosch et al. CURRENT OPINION IN PLANT BIOLOGY
- Congenital long QT syndrome presenting with a history of epilepsy: Misdiagnosis or relationship between channelopathies of the heart and brain?
- (2009) Chikaya Omichi et al. EPILEPSIA
- Role of intracellular domains in the function of the herg potassium channel
- (2009) Moza Al-Owais et al. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
- Rapid component IKr of cardiac delayed rectifier potassium currents in guinea-pig is inhibited by α1-adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways
- (2009) Sen Wang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test
- (2009) Jamie D. Kapplinger et al. HEART RHYTHM
- Expression and immunolocalization of ERG1 potassium channels in the rat kidney
- (2009) Rolando Carrisoza et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Hsp40 Chaperones Promote Degradation of the hERG Potassium Channel
- (2009) Valerie E. Walker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Absence of Direct Cyclic Nucleotide Modulation of mEAG1 and hERG1 Channels Revealed with Fluorescence and Electrophysiological Methods
- (2009) Tinatin I. Brelidze et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3
- (2009) Cecile Terrenoire et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gender Differences in the Effect of Auditory Stimuli on Ventricular Repolarization in Healthy Subjects
- (2009) MIKIKO NAKAGAWA et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype
- (2009) JING TING ZHAO et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- In Vivo Effects of the IKr Agonist NS3623 on Cardiac Electrophysiology of the Guinea Pig
- (2009) Rie Schultz Hansen et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines
- (2009) Jun Guo et al. JOURNAL OF CLINICAL INVESTIGATION
- Common candidate gene variants are associated with QT interval duration in the general population
- (2009) A. Marjamaa et al. JOURNAL OF INTERNAL MEDICINE
- Side Chain Flexibilities in the Human Ether-a-go-go Related Gene Potassium Channel (hERG) Together with Matched-Pair Binding Studies Suggest a New Binding Mode for Channel Blockers
- (2009) Ulrich Zachariae et al. JOURNAL OF MEDICINAL CHEMISTRY
- Docking Model of Drug Binding to the Human Ether-à-go-go Potassium Channel Guided by Tandem Dimer Mutant Patch-Clamp Data: A Synergic Approach
- (2009) Yumi N. Imai et al. JOURNAL OF MEDICINAL CHEMISTRY
- Regulation of the Kv2.1 Potassium Channel by MinK and MiRP1
- (2009) Zoe A. McCrossan et al. JOURNAL OF MEMBRANE BIOLOGY
- A novel computational model of the human ventricular action potential and Ca transient
- (2009) Eleonora Grandi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cholesterol modulates ion channels via down-regulation of phosphatidylinositol 4,5-bisphosphate
- (2009) Yoon Sun Chun et al. JOURNAL OF NEUROCHEMISTRY
- Loss of functional K+channels encoded byether-à-go-go-relatedgenes in mouse myometrium prior to labour onset
- (2009) I. A. Greenwood et al. JOURNAL OF PHYSIOLOGY-LONDON
- Similarity-based SIBAR descriptors for classification of chemically diverse hERG blockers
- (2009) Khac-Minh Thai et al. MOLECULAR DIVERSITY
- Intracellular Potassium Stabilizes Human Ether-a-go-go-Related Gene Channels for Export from Endoplasmic Reticulum
- (2009) L. Wang et al. MOLECULAR PHARMACOLOGY
- Pharmacological Removal of Human Ether-a-go-go-Related Gene Potassium Channel Inactivation by 3-Nitro-N-(4-phenoxyphenyl) Benzamide (ICA-105574)
- (2009) A. C. Gerlach et al. MOLECULAR PHARMACOLOGY
- A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
- (2009) Stephen J Huffaker et al. NATURE MEDICINE
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death
- (2009) Wayne A. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance
- (2009) M. Perry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels
- (2009) A. S. Gustina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- hERG1 channel activators: A new anti-arrhythmic principle
- (2009) Morten Grunnet et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution
- (2009) X. Tao et al. SCIENCE
- A Kv channel with an altered activation gate sequence displays both “fast” and “slow” activation kinetics
- (2008) Alain J. Labro et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Cytoplasmic cAMP concentrations in intact cardiac myocytes
- (2008) Radu V. Iancu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Erg K+ channels modulate contractile activity in the bovine epididymal duct
- (2008) Marco Mewe et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study
- (2008) Olli T. Raitakari et al. ANNALS OF MEDICINE
- PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
- (2008) Byung-Chang Suh et al. Annual Review of Biophysics
- Development of the Predictor hERG Fluorescence Polarization Assay Using a Membrane Protein Enrichment Approach
- (2008) David R. Piper et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein
- (2008) Jayasri Nanduri et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Insight into the Mechanism of Inactivation and pH Sensitivity in Potassium Channels from Molecular Dynamics Simulations†
- (2008) Phillip J. Stansfeld et al. BIOCHEMISTRY
- Support vector machines classification of hERG liabilities based on atom types
- (2008) Lei Jia et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines
- (2008) H R Lu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery
- (2008) T P Barros et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacology of the short QT syndrome N588K-hERG K+channel mutation: differential impact on selected class I and class III antiarrhythmic drugs
- (2008) M J McPate et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor
- (2008) Y H Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome
- (2008) Thomas G. Diness et al. CARDIOVASCULAR RESEARCH
- Cooperative Interactions Between R531 and Acidic Residues in the Voltage Sensing Module of hERG1 Channels
- (2008) David R. Piper et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Both EGFR kinase and Src-related tyrosine kinases regulate human ether-à-go-go-related gene potassium channels
- (2008) De-Yong Zhang et al. CELLULAR SIGNALLING
- Combining Cluster Analysis, Feature Selection and Multiple Support Vector Machine Models for the Identification of Human Ether-a-go-go Related Gene Channel Blocking Compounds
- (2008) Britta Nisius et al. Chemical Biology & Drug Design
- hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias
- (2008) John S. Mitcheson CHEMICAL RESEARCH IN TOXICOLOGY
- Deficient Zebrafish Ether-à-Go-Go –Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants
- (2008) David Hassel et al. CIRCULATION
- Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes
- (2008) Jérôme Leroy et al. CIRCULATION RESEARCH
- Homozygous Missense N629D hERG (KCNH2) Potassium Channel Mutation Causes Developmental Defects in the Right Ventricle and Its Outflow Tract and Embryonic Lethality
- (2008) Guo Qi Teng et al. CIRCULATION RESEARCH
- Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-Specific Mutation Associated With Long-QT Syndrome
- (2008) Harinath Sale et al. CIRCULATION RESEARCH
- Ligand Structural Aspects of hERG Channel Blockade
- (2008) Alex Aronov CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Kv11.1 channel subunit composition includes minK and varies developmentally in mouse cardiac muscle
- (2008) Xun Wang et al. DEVELOPMENTAL DYNAMICS
- Stimulation of N-Terminal Truncated Isoform of Androgen Receptor Stabilizes Human Ether-á-go-go-Related Gene-Encoded Potassium Channel Protein via Activation of Extracellular Signal Regulated Kinase 1/2
- (2008) Zhi-Yuan Wu et al. ENDOCRINOLOGY
- Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model
- (2008) Torben Peitersen et al. HEART RHYTHM
- Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome
- (2008) Chinmay Patel et al. HEART RHYTHM
- Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation
- (2008) Zahurul A. Bhuiyan et al. HEART RHYTHM
- A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome
- (2008) Lia Crotti et al. HEART RHYTHM
- A novel KCNH2 mutation as a modifier for short QT interval
- (2008) Hideki Itoh et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- The Pore Domain Outer Helix Contributes to Both Activation and Inactivation of the hERG K+Channel
- (2008) Pengchu Ju et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small GTPase Determinants for the Golgi Processing and Plasmalemmal Expression of Human Ether-a-go-go Related (hERG) K+Channels
- (2008) Brian P. Delisle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling
- (2008) Sarah L. Wynia-Smith et al. JOURNAL OF GENERAL PHYSIOLOGY
- A-Kinase Anchoring Protein Targeting of Protein Kinase A and Regulation of HERG Channels
- (2008) Yan Li et al. JOURNAL OF MEMBRANE BIOLOGY
- A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome
- (2008) Qiuming Gong et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator
- (2008) Franck Potet et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Delayed-rectifier potassium currents and the control of cardiac repolarization: Noble and Tsien 40 years after
- (2008) Stanley Nattel JOURNAL OF PHYSIOLOGY-LONDON
- ERG voltage-gated K+channels regulate excitability and discharge dynamics of the medial vestibular nucleus neurones
- (2008) Mauro Pessia et al. JOURNAL OF PHYSIOLOGY-LONDON
- hERG Classification Model Based on a Combination of Support Vector Machine Method and GRIND Descriptors
- (2008) Qiyuan Li et al. MOLECULAR PHARMACEUTICS
- Topological Mapping of the Asymmetric Drug Binding to the Human Ether-a-go-go-Related Gene Product (HERG) Potassium Channel by Use of Tandem Dimers
- (2008) T. Myokai et al. MOLECULAR PHARMACOLOGY
- Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels
- (2008) M. J. Perrin et al. MOLECULAR PHARMACOLOGY
- One step at a time: endoplasmic reticulum-associated degradation
- (2008) Shruthi S. Vembar et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy
- (2008) J. N. Johnson et al. NEUROLOGY
- Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
- (2008) Gary A. Gintant PHARMACOLOGY & THERAPEUTICS
- The hERG potassium channel and hERG screening for drug-induced torsades de pointes
- (2008) Jules C. Hancox et al. PHARMACOLOGY & THERAPEUTICS
- The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity
- (2008) S. Gentile et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel nonsense mutation Y652X in the S6/pore region of human ether-go-go gene found in a long QT syndrome family
- (2008) Yaxun Sun et al. SCANDINAVIAN CARDIOVASCULAR JOURNAL
- Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome
- (2007) H Takemasa et al. BRITISH JOURNAL OF PHARMACOLOGY
- State dependent dissociation of HERG channel inhibitors
- (2007) D Stork et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Composite Model for hERG Blockade
- (2007) Christian Kramer et al. ChemMedChem
- Modeling the hERG potassium channel in a phospholipid bilayer: Molecular dynamics and drug docking studies
- (2007) Matteo Masetti et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Evaluation of zebrafish embryos as a model for assessing inhibition of hERG
- (2007) S.W. Mittelstadt et al. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now