Toward predictive models for drug-induced liver injury in humans: are we there yet?

A Unifying Ontology to Integrate Histological and Clinical Observations for Drug-Induced Liver Injury

(2013) Yuping Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

The Liver Toxicity Knowledge Base: A Systems Approach to a Complex End Point

(2013) M Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hepatotoxicity: A scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action

(2013) M. Hewitt et al.   CRITICAL REVIEWS IN TOXICOLOGY

Current Challenges and Controversies in Drug-Induced Liver Injury

(2013) Alberto Corsini et al.   DRUG SAFETY

Quantitative Structure-Activity Relationship Models for Predicting Drug-Induced Liver Injury Based on FDA-Approved Drug Labeling Annotation and Using a Large Collection of Drugs

(2013) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

(2012) Richard Kia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

(2012) Melanie Z. Sakatis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug-induced liver injury

(2012) Lafaine M. Grant et al.   CURRENT OPINION IN GASTROENTEROLOGY

Comparisons betweenin vitrowhole cell imaging andin vivozebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development

(2012) Adrian Hill et al.   DRUG METABOLISM REVIEWS

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery

(2012) Craig E Thomas et al.   Expert Opinion on Drug Discovery

In silicomodels for drug-induced liver injury – current status

(2012) Katarzyna R Przybylak et al.   Expert Opinion on Drug Metabolism & Toxicology

LiverTox: A website on drug-induced liver injury

(2012) Jay H. Hoofnagle et al.   HEPATOLOGY

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

(2012) Minjun Chen et al.   HEPATOLOGY

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs

(2012) Thomas J. Urban et al.   Pharmacogenetics and Genomics

Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here?

(2012) Thomas J Urban et al.   PHARMACOGENOMICS

Predictive Modeling of Chemical Hazard by Integrating Numerical Descriptors of Chemical Structures and Short-term Toxicity Assay Data

(2012) Ivan Rusyn et al.   TOXICOLOGICAL SCIENCES

Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

(2012) Mathieu Porceddu et al.   TOXICOLOGICAL SCIENCES

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science

(2012) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

(2012) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

R2R - software to speed the depiction of aesthetic consensus RNA secondary structures

(2011) Zasha Weinberg et al.   BMC BIOINFORMATICS

Mining FDA drug labels using an unsupervised learning technique - topic modeling

(2011) Halil Bisgin et al.   BMC BIOINFORMATICS

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?

(2011) Min Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Predicting Drug-Induced Hepatotoxicity Using QSAR and Toxicogenomics Approaches

(2011) Yen Low et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Animal models of idiosyncratic drug-induced liver injury—Current status

(2011) Robert A. Roth et al.   CRITICAL REVIEWS IN TOXICOLOGY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Mixed learning algorithms and features ensemble in hepatotoxicity prediction

(2011) Chin Yee Liew et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A genetically humanized mouse model for hepatitis C virus infection

(2011) Marcus Dorner et al.   NATURE

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

(2011) Zhichao Liu et al.   PLoS Computational Biology

Modeling Liver-Related Adverse Effects of Drugs UsingkNearest Neighbor Quantitative Structure−Activity Relationship Method

(2010) Amie D. Rodgers et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A Predictive Ligand-Based Bayesian Model for Human Drug-Induced Liver Injury

(2010) S. Ekins et al.   DRUG METABOLISM AND DISPOSITION

Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™

(2010) Ayako Suzuki et al.   DRUG SAFETY

Predicting and preventing acute drug-induced liver injury: what's new in 2010?

(2010) Gordon Liss et al.   Expert Opinion on Drug Metabolism & Toxicology

Pharmacogenetics of drug-induced liver injury

(2010) Stefan Russmann et al.   HEPATOLOGY

Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment method

(2010) Don C. Rockey et al.   HEPATOLOGY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Identification of classifier genes for hepatotoxicity prediction in non steroidal anti inflammatory drugs

(2010) Hye Jin Cha et al.   Molecular & Cellular Toxicology

Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes

(2010) W Shi et al.   PHARMACOGENOMICS JOURNAL

The Evolution of Bioinformatics in Toxicology: Advancing Toxicogenomics

(2010) C. A. Afshari et al.   TOXICOLOGICAL SCIENCES

Cheminformatics Analysis of Assertions Mined from Literature That Describe Drug-Induced Liver Injury in Different Species

(2009) Denis Fourches et al.   CHEMICAL RESEARCH IN TOXICOLOGY

An Expert System Approach to the Assessment of Hepatotoxic Potential

(2009) Carol A. Marchant et al.   CHEMISTRY & BIODIVERSITY

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

(2009) T. Usui et al.   DRUG METABOLISM AND DISPOSITION

Intrinsic versus Idiosyncratic Drug-Induced Hepatotoxicity--Two Villains or One?

(2009) R. A. Roth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Japanese toxicogenomics project: Application of toxicogenomics

(2009) Takeki Uehara et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities

(2009) Edwin J. Matthews et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

(2009) Benjamin D. Cosgrove et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity

(2009) Richard D. Beger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

What is idiosyncratic hepatotoxicity? What is it not?

(2008) John R. Senior   HEPATOLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

(2008) Laura K. Schnackenberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY