Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications

(2013) David E. Smith et al.   MOLECULAR ASPECTS OF MEDICINE

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transporters in human platelets: physiologic function and impact for pharmacotherapy

(2012) G. Jedlitschky et al.   BLOOD

Highlights from the International Transporter Consortium Second Workshop

(2012) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

(2012) Evita van de Steeg et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling

(2012) Matthias B. Wittwer et al.   JOURNAL OF MEDICINAL CHEMISTRY

The bile salt export pump (BSEP) in health and disease

(2012) Ralf Kubitz et al.   Clinics and Research in Hepatology and Gastroenterology

The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease

(2011) Sarah A. Ingersoll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Common 5′-UTR Variant in MATE2-K Is Associated With Poor Response to Metformin

(2011) J H Choi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects

(2011) H Kusuhara et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics

(2011) Katja Damme et al.   DRUG METABOLISM REVIEWS

Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis

(2011) Bruno Stieger et al.   Expert Opinion on Drug Metabolism & Toxicology

In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

(2010) S. B. Yanni et al.   DRUG METABOLISM AND DISPOSITION

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy

(2010) Christiane Pauli-Magnus et al.   SEMINARS IN LIVER DISEASE

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

The International Transporter Consortium: A Collaborative Group of Scientists From Academia, Industry, and the FDA

(2009) S-M Huang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

(2009) Bruno Stieger   DRUG METABOLISM REVIEWS

Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1

(2009) Ji Ha Choi et al.   Pharmacogenetics and Genomics

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

(2008) P. Krishnamurthy et al.   CANCER RESEARCH

Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer

(2008) James J. Farrell et al.   GASTROENTEROLOGY

Prediction and Identification of Drug Interactions with the Human ATP-Binding Cassette Transporter Multidrug-Resistance Associated Protein 2 (MRP2; ABCC2)

(2008) Jenny M. Pedersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Targeted Disruption of Peptide TransporterPept1Gene in Mice Significantly Reduces Dipeptide Absorption in Intestine

(2008) Yongun Hu et al.   MOLECULAR PHARMACEUTICS

Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

(2008) F RUSSEL et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Physiology of bile secretion

(2008) Alejandro Esteller   WORLD JOURNAL OF GASTROENTEROLOGY

SLC28 genes and concentrative nucleoside transporter (CNT) proteins

(2008) M. Pastor-Anglada et al.   XENOBIOTICA

Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins

(2008) J. D. Young et al.   XENOBIOTICA