Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye

(2011) K. Pernelle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells

(2010) Yuichiro Kanno et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2

(2010) Susan P. Rhodes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s

(2009) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Biobased Performance Bioplastic: Mirel

(2009) Barry E. DiGregorio   CHEMISTRY & BIOLOGY

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of genes identified by microarray analysis in favorable neuroblastoma

(2009) Naomi Kamei et al.   PEDIATRIC SURGERY INTERNATIONAL

Toxicity Testing in the 21st Century: A View from the Pharmaceutical Industry

(2009) James S. MacDonald et al.   TOXICOLOGICAL SCIENCES

Cell based approaches for evaluation of drug-induced liver injury

(2009) Mhairi L. Greer et al.   TOXICOLOGY

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

(2009) Miia Turpeinen et al.   TOXICOLOGY IN VITRO

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

(2008) M. Gomez-Lechon et al.   CURRENT DRUG METABOLISM

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices

(2008) P. Olinga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pregnane X Receptor Protects HepG2 Cells from BaP-Induced DNA Damage

(2008) Christine Naspinski et al.   TOXICOLOGICAL SCIENCES

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells

(2008) Carine B. Lambert et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach

(2008) H.H.J. Gerets et al.   TOXICOLOGY IN VITRO