Melanoma metastasis: new concepts and evolving paradigms

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

A Wnt-er Migration: The Confusing Role of  -Catenin in Melanoma Metastasis

(2013) M. R. Webster et al.   Science Signaling

The Small GTPase ARF6 Stimulates  -Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

(2013) A. H. Grossmann et al.   Science Signaling

The Impact of Obesity on Breast Cancer: A Retrospective Review

(2012) Danielle J. Haakinson et al.   ANNALS OF SURGICAL ONCOLOGY

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma

(2012) Jared J Gartner et al.   BMC GENOMICS

Location, location, location: the BRMS1 protein and melanoma progression

(2012) Adam I Riker et al.   BMC Medicine

Metabolic risk factors and skin cancer in the Metabolic Syndrome and Cancer Project (Me-Can)

(2012) G. Nagel et al.   BRITISH JOURNAL OF DERMATOLOGY

LKB1/STK11 Inactivation Leads to Expansion of a Prometastatic Tumor Subpopulation in Melanoma

(2012) Wenjin Liu et al.   CANCER CELL

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

(2012) Tara Karnezis et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma

(2012) Stuart G. Jarrett et al.   CLINICAL & EXPERIMENTAL METASTASIS

Update on the Current State of Melanoma Incidence

(2012) Emily G. Little et al.   DERMATOLOGIC CLINICS

WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis

(2012) Pei-Tzu Yang et al.   EMBO Molecular Medicine

BRAF/NRASMutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma

(2012) Maria Colombino et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/ -Catenin Signaling in Human Melanoma Cells

(2012) T. Yaguchi et al.   JOURNAL OF IMMUNOLOGY

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials

(2012) Annemijn M Algra et al.   LANCET ONCOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Beta-catenin inhibits melanocyte migration but induces melanoma metastasis

(2012) S J Gallagher et al.   ONCOGENE

Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion

(2012) J Ferguson et al.   ONCOGENE

Efficient gene expression profiling of laser-microdissected melanoma metastases

(2012) Samira Makhzami et al.   Pigment Cell & Melanoma Research

Emerging molecular targets in melanoma invasion and metastasis

(2012) Jose L. Orgaz et al.   Pigment Cell & Melanoma Research

Time Course and Pattern of Metastasis of Cutaneous Melanoma Differ between Men and Women

(2012) Liljana Mervic   PLoS One

Sox10 Controls Migration of B16F10 Melanoma Cells through Multiple Regulatory Target Genes

(2012) Ikjoo Seong et al.   PLoS One

A Seven-Marker Signature and Clinical Outcome in Malignant Melanoma: A Large-Scale Tissue-Microarray Study with Two Independent Patient Cohorts

(2012) Stefanie Meyer et al.   PLoS One

Germline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families

(2012) Ching-Ni Jenny Njauw et al.   PLoS One

Circulating Tumor Cells in Melanoma Patients

(2012) Gary A. Clawson et al.   PLoS One

Cadm1 Is a Metastasis Susceptibility Gene That Suppresses Metastasis by Modifying Tumor Interaction with the Cell-Mediated Immunity

(2012) Farhoud Faraji et al.   PLoS Genetics

TYRP1 mRNA expression in melanoma metastases correlates with clinical outcome

(2011) F Journe et al.   BRITISH JOURNAL OF CANCER

NRAS mutation status is an independent prognostic factor in metastatic melanoma

(2011) John A. Jakob et al.   CANCER

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A

(2011) Imanol Arozarena et al.   CANCER CELL

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Intravital Imaging

(2011) Mikael J. Pittet et al.   CELL

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

(2011) Piul Rabbani et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Genetic factors in metastatic progression of cutaneous melanoma: the future role of circulating melanoma cells in prognosis and management

(2011) A. Ireland et al.   CLINICAL & EXPERIMENTAL METASTASIS

MDA-9/syntenin: a positive gatekeeper of melanoma metastasis

(2011) Swadesh et al.   Frontiers in Bioscience-Landmark

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis

(2011) Sivan Izraely et al.   INTERNATIONAL JOURNAL OF CANCER

Prognosis in Patients With Sentinel Node–Positive Melanoma Is Accurately Defined by the Combined Rotterdam Tumor Load and Dewar Topography Criteria

(2011) Augustinus P.T. van der Ploeg et al.   JOURNAL OF CLINICAL ONCOLOGY

The biology of micrometastases from uveal melanoma

(2011) N. J. Borthwick et al.   JOURNAL OF CLINICAL PATHOLOGY

Microenvironment-Derived IL-1 and IL-17 Interact in the Control of Lung Metastasis

(2011) Y. Carmi et al.   JOURNAL OF IMMUNOLOGY

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma

(2011) Todd D Prickett et al.   NATURE GENETICS

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

In melanoma, beta-catenin is a suppressor of invasion

(2011) I Arozarena et al.   ONCOGENE

Hypoxia and MITF control metastatic behaviour in mouse and human melanoma cells

(2011) Y Cheli et al.   ONCOGENE

Modelling melanoma in mice

(2011) Graeme J. Walker et al.   Pigment Cell & Melanoma Research

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells

(2011) Delphine Javelaud et al.   Pigment Cell & Melanoma Research

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching

(2011) Ossia M. Eichhoff et al.   Pigment Cell & Melanoma Research

The role of mitogen- and stress-activated protein kinase pathways in melanoma

(2011) Pablo Lopez-Bergami   Pigment Cell & Melanoma Research

Network-Guided Analysis of Genes with Altered Somatic Copy Number and Gene Expression Reveals Pathways Commonly Perturbed in Metastatic Melanoma

(2011) Armand Valsesia et al.   PLoS One

BRAF Mutations in Advanced Cancers: Clinical Characteristics and Outcomes

(2011) Hazem El-Osta et al.   PLoS One

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

Pathways to Melanoma

(2011) Justin M. Ko et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

(2011) Colin R. Lindsay et al.   Nature Communications

Circulating Benign Nevus Cells Detected by ISET Technique

(2010) Vincenzo De Giorgi et al.   ARCHIVES OF DERMATOLOGY

Suppression of Casein Kinase 1  in Melanoma Cells Induces a Switch in  -Catenin Signaling to Promote Metastasis

(2010) T. Sinnberg et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?

(2010) József Tímár et al.   CLINICAL & EXPERIMENTAL METASTASIS

Modeling metastasis in the mouse

(2010) Paula D Bos et al.   CURRENT OPINION IN PHARMACOLOGY

EORTC Melanoma Group sentinel node protocol identifies high rate of submicrometastases according to Rotterdam Criteria

(2010) Augustinus P.T. van der Ploeg et al.   EUROPEAN JOURNAL OF CANCER

Cellular origin and developmental mechanisms during the formation of skin melanocytes

(2010) Patrik Ernfors   EXPERIMENTAL CELL RESEARCH

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

(2010) Jo Eyles et al.   JOURNAL OF CLINICAL INVESTIGATION

Melanoma biomarker expression in melanocytic tumor progression: a tissue microarray study

(2010) Rosalynn M. Nazarian et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

(2010) C Nogueira et al.   ONCOGENE

Mouse melanoma models and cell lines

(2010) William E. Damsky Jr et al.   Pigment Cell & Melanoma Research

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Skeletal Muscle Phenotypically Converts and Selectively Inhibits Metastatic Cells in Mice

(2010) Ara Parlakian et al.   PLoS One

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Decoding Melanoma Metastasis

(2010) William E. Damsky et al.   Cancers

Benign Nodal Nevi Frequently Harbor the Activating V600E BRAF Mutation

(2009) Janis M. Taube et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Outcome of Patients with a Positive Sentinel Lymph Node who do not Undergo Completion Lymphadenectomy

(2009) T. Peter Kingham et al.   ANNALS OF SURGICAL ONCOLOGY

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

(2009) S. Pinner et al.   CANCER RESEARCH

Adjuvant bisphosphonates in breast cancer: Are we witnessing the emergence of a new therapeutic strategy?

(2009) R.E. Coleman   EUROPEAN JOURNAL OF CANCER

Transcriptional Regulation in Melanoma

(2009) Devarati Mitra et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis

(2009) Nikolas H. Stoecklein et al.   INTERNATIONAL JOURNAL OF CANCER

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms

(2009) Bonnie E. Gould Rothberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Macrophage Markers in Serum and Tumor Have Prognostic Impact in American Joint Committee on Cancer Stage I/II Melanoma

(2009) Trine O. Jensen et al.   JOURNAL OF CLINICAL ONCOLOGY

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Endocrine Therapy plus Zoledronic Acid in Premenopausal Breast Cancer

(2009) Michael Gnant et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

(2009) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Dormancy of metastatic melanoma

(2009) Liliana Ossowski et al.   Pigment Cell & Melanoma Research

Inflammation and melanoma metastasis

(2009) Vladislava O. Melnikova et al.   Pigment Cell & Melanoma Research

The PTEN-AKT3 signaling cascade as a therapeutic target in melanoma

(2009) SubbaRao V. Madhunapantula et al.   Pigment Cell & Melanoma Research

Sentinel Node Tumor Burden According to the Rotterdam Criteria Is the Most Important Prognostic Factor for Survival in Melanoma Patients

(2008) Alexander C. J. van Akkooi et al.   ANNALS OF SURGERY

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin

(2008) Sandra S. McAllister et al.   CELL

Molecular Pathways Mediating Liver Metastasis in Patients with Uveal Melanoma

(2008) S. Bakalian et al.   CLINICAL CANCER RESEARCH

Gene silencing ofβ-cateninin melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice

(2008) Yuki Takahashi et al.   INTERNATIONAL JOURNAL OF CANCER

Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

(2008) K. Podsypanina et al.   SCIENCE