Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

CONTRA: copy number analysis for targeted resequencing

(2012) Jason Li et al.   BIOINFORMATICS

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

The Aurora Kinase A Inhibitor MLN8237 Enhances Cisplatin-Induced Cell Death in Esophageal Adenocarcinoma Cells

(2012) V. Sehdev et al.   MOLECULAR CANCER THERAPEUTICS

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours

(2012) Paul Krimpenfort et al.   NATURE

Genomic characterisation of acral melanoma cell lines

(2012) Simon J. Furney et al.   Pigment Cell & Melanoma Research

Synergistic Cytotoxic Effect of the Microtubule Inhibitor Marchantin A fromMarchantia polymorphaand the Aurora Kinase Inhibitor MLN8237 on Breast Cancer CellsIn Vitro

(2012) J. Jensen et al.   PLANTA MEDICA

Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV

(2011) Jarupon Fah Sathirapongsasuti et al.   BIOINFORMATICS

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

(2011) M. G. Manfredi et al.   CLINICAL CANCER RESEARCH

Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod- Driven Motility and Cell-Cycle Progression

(2011) Ang Li et al.   DEVELOPMENTAL CELL

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

Btrim: A fast, lightweight adapter and quality trimming program for next-generation sequencing technologies

(2011) Yong Kong   GENOMICS

Protein phosphatases and the regulation of mitosis

(2011) F. A. Barr et al.   JOURNAL OF CELL SCIENCE

Phosphoproteomic Screen Identifies Potential Therapeutic Targets in Melanoma

(2011) K. Tworkoski et al.   MOLECULAR CANCER RESEARCH

DCC constrains tumour progression via its dependence receptor activity

(2011) Marie Castets et al.   NATURE

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

(2011) Meng Li et al.   NATURE GENETICS

BRAF targeted therapy changes the treatment paradigm in melanoma

(2011) Antoni Ribas et al.   Nature Reviews Clinical Oncology

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin

(2011) David C. Whiteman et al.   Pigment Cell & Melanoma Research

BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site

(2011) Jürgen Bauer et al.   Pigment Cell & Melanoma Research

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

(2011) Colin R. Lindsay et al.   Nature Communications

The Distribution and Most Recent Common Ancestor of the 17q21 Inversion in Humans

(2010) Michael P. Donnelly et al.   AMERICAN JOURNAL OF HUMAN GENETICS

MU2A—reconciling the genome and transcriptome to determine the effects of base substitutions

(2010) Vijay Garla et al.   BIOINFORMATICS

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates  -H2AX

(2010) P. Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

Phase I Study of the Selective Aurora A Kinase Inhibitor MLN8054 in Patients with Advanced Solid Tumors: Safety, Pharmacokinetics, and Pharmacodynamics

(2010) T. Macarulla et al.   MOLECULAR CANCER THERAPEUTICS

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

(2010) Xiaobo Wang et al.   NATURE CELL BIOLOGY

Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis

(2010) C Nogueira et al.   ONCOGENE

Meenhard Herlyn

(2010) Ruth Halaban   Pigment Cell & Melanoma Research

Genetic and morphologic features for melanoma classification

(2010) Sigrid M. C. Broekaert et al.   Pigment Cell & Melanoma Research

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data

(2009) Qunyuan Zhang et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint

(2009) Mylavarapu V S Sivaram et al.   EMBO JOURNAL

Genome-wide screen of promoter methylation identifies novel markers in melanoma

(2009) Y. Koga et al.   GENOME RESEARCH

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications

(2009) Ruth Halaban et al.   PLoS One

Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma

(2008) D. A. Solomon et al.   CANCER RESEARCH

Netrin-1 and its receptors in tumour growth promotion

(2008) Agnès Bernet et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Improving Melanoma Classification by Integrating Genetic and Morphologic Features

(2008) Amaya Viros et al.   PLOS MEDICINE