Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion

AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study

(2017) R. Dummer et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer

(2011) M. N. Fornier et al.   ANNALS OF ONCOLOGY

Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A

(2011) Imanol Arozarena et al.   CANCER CELL

Phase II Trial of Dasatinib for Patients with Acquired Resistance to Treatment with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Erlotinib or Gefitinib

(2011) Melissa L. Johnson et al.   Journal of Thoracic Oncology

Biological challenges of BRAF inhibitor therapy

(2011) Igor Puzanov et al.   Molecular Oncology

In melanoma, beta-catenin is a suppressor of invasion

(2011) I Arozarena et al.   ONCOGENE

BRAF as therapeutic target in melanoma

(2010) Claudia Wellbrock et al.   BIOCHEMICAL PHARMACOLOGY

A phase 2 trial of dasatinib in advanced melanoma

(2010) Harriet M. Kluger et al.   CANCER

Activation of FOXO3a Is Sufficient to Reverse Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor Chemoresistance in Human Cancer

(2010) Jer-Yen Yang et al.   CANCER RESEARCH

Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells

(2010) Y. N. V. Gopal et al.   CANCER RESEARCH

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Elevated c-Src and c-Yes expression in malignant skin cancers

(2010) Jang Lee et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extracellular Signal-Regulated Kinase Promotes Rho-Dependent Focal Adhesion Formation by Suppressing p190A RhoGAP

(2010) A. K. Pullikuth et al.   MOLECULAR AND CELLULAR BIOLOGY

MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation

(2010) Svenja Meierjohann et al.   Molecular Cancer

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways

(2010) S-H Lee et al.   ONCOGENE

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

(2009) Shuh Narumiya et al.   CANCER AND METASTASIS REVIEWS

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma

(2009) Jade Homsi et al.   MELANOMA RESEARCH

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

(2009) Tim P. Green et al.   Molecular Oncology

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Src and focal adhesion kinase as therapeutic targets in cancer

(2008) Valerie G Brunton et al.   CURRENT OPINION IN PHARMACOLOGY

p190RhoGAP is the convergence point of adhesion signals from α5β1integrin and syndecan-4

(2008) Mark D. Bass et al.   JOURNAL OF CELL BIOLOGY

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines

(2008) Alex J Eustace et al.   Journal of Translational Medicine

Inhibition of Src Family Kinases with Dasatinib Blocks Migration and Invasion of Human Melanoma Cells

(2008) R. Buettner et al.   MOLECULAR CANCER RESEARCH

mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src

(2008) H. Boukerche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA