Article
Oncology
Manali S. Phadke, Zhihua Chen, Jiannong Li, Eslam Mohamed, Michael A. Davies, Inna Smalley, Derek R. Duckett, Vinayak Palve, Brian J. Czerniecki, Peter A. Forsyth, David Noyes, Dennis O. Adeegbe, Zeynep Eroglu, Kimberly T. Nguyen, Kenneth Y. Tsai, Uwe Rix, Christin E. Burd, Yian A. Chen, Paulo C. Rodriguez, Keiran S. M. Smalley
Summary: In mouse models of BRAF- and NRAS-mutant melanoma, upfront immunotherapy enhances responses to targeted therapy. The sequence of IT -> TT modulates the immune environment, increasing infiltration of T cells and decreasing tumor-associated macrophages, leading to improved therapeutic outcomes. Durable responses to the IT -> TT sequence depend on T-cell activity and enrichment of a population of melanoma cells with increased expression of MHC class I and melanoma antigens.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Virology
Sidi Yang, Liu Cao, Wenting Xu, Tiefeng Xu, Birong Zheng, Yanxi Ji, Siyao Huang, Lihong Liu, Jie Du, Hong Peng, Huan Zhang, Jingdiao Chen, Bixia Ke, Huanying Zheng, Xiaoling Deng, Chunmei Li, Deyin Guo
Summary: Researchers performed systematic comparisons of several mouse models expressing human angiotensin converting enzyme 2 (hACE2), the receptor used by SARS-CoV-2, and found differences in the distribution of lesions and characteristics of induced pneumonia. Understanding the similarities and differences in model-specific pathologies can aid in better understanding the pathogenic process of SARS-CoV-2 infection and the development of effective medications and prophylactic treatments for COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Robert J. Torphy, Yi Sun, Ronggui Lin, Alayna Caffrey-Carr, Yuki Fujiwara, Felix Ho, Emily N. Miller, Martin D. McCarter, Traci R. Lyons, Richard D. Schulick, Ross M. Kedl, Yuwen Zhu
Summary: This study demonstrates that GPR182 contributes to immunotherapy resistance in immunologically cold tumors by scavenging important chemokines. GPR182 deficiency increases T cell infiltration and improves antitumor immunity, sensitizing poorly immunogenic tumors to immune checkpoint blockade and adoptive cellular therapies.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Hussein Akil, Mercedes Quintana, Jeremy H. Raymond, Tommy Billoux, Valentin Benboubker, Sophie Besse, Philippe Auzeloux, Veronique Delmas, Valerie Petit, Lionel Larue, Michel D'Incan, Francoise Degoul, Jacques Rouanet
Summary: Targeted radionuclide therapy (TRT) combined with MAPK/ERK inhibitors shows additive efficiency in BRAF and NRAS mutant melanoma cells. TRT has a significant therapeutic effect on NRAS(Q61K) mutated melanoma and reduces metastasis capacity.
Article
Multidisciplinary Sciences
Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Salamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Summary: This study identified elevated PDE4 signaling in human cortical neurons differentiated from iPSCs with a DISC1 mutation, and demonstrated that inhibition of PDE4 or activation of the cAMP signaling pathway can rescue synaptic deficits. A knock-in mouse model carrying the same patient mutation in the Disc1 gene showed similar results, indicating a crucial role of the PDE4 signaling pathway in synaptic, social, and cognitive behavioral deficits.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Zackie Aktary, Jeremy H. Raymond, Marie Pouteaux, Veronique Delmas, Valerie Petit, Lionel Larue
Summary: The establishment of consistent genetically modified mouse melanoma models and cell lines is crucial for prevention and treatment. This study reviews different mouse melanoma cell lines and explores the changes they undergo through molecular characterization and modification of the genome and microenvironment. These cell lines with defined genetic mutations enable the testing of innovative therapies and have relevance to human disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Orthopedics
Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little
Summary: A single slide for evaluating diverse histopathological changes in different joint tissues and disease stages can reduce scoring time and maintain sensitivity and specificity of the analysis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Medicine, General & Internal
Justin Couetil, Ziyu Liu, Kun Huang, Jie Zhang, Ahmed K. K. Alomari
Summary: In this study, machine learning approaches were used to analyze melanoma histopathological images, resulting in a set of image features that can help clinicians identify high-risk-of-metastasis patients for increased clinical follow-up and precision treatment. The results show that survival and metastasis can be predicted using simple models and cell morphological features.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Lazaro Hiram Betancourt, Jeovanis Gil, Aniel Sanchez, Viktoria Doma, Magdalena Kuras, Jimmy Rodriguez Murillo, Erika Velasquez, Ugur Cakir, Yonghyo Kim, Yutaka Sugihara, Indira Pla Parada, Beata Szeitz, Roger Appelqvist, Elisabet Wieslander, Charlotte Welinder, Natalia Pinto de Almeida, Nicole Woldmar, Matilda Marko-Varga, Jonatan Eriksson, Krzysztof Pawlowski, Bo Baldetorp, Christian Ingvar, Hakan Olsson, Lotta Lundgren, Henrik Lindberg, Henriett Oskolas, Boram Lee, Ethan Berge, Marie Sjogren, Carina Eriksson, Dasol Kim, Ho Jeong Kwon, Beatrice Knudsen, Melinda Rezeli, Johan Malm, Runyu Hong, Peter Horvath, A. Marcell Szasz, Jozsef Timar, Sarolta Karpati, Peter Horvatovich, Tasso Miliotis, Toshihide Nishimura, Harubumi Kato, Erik Steinfelder, Madalina Oppermann, Ken Miller, Francesco Florindi, Quimin Zhou, Gilberto B. Domont, Luciana Pizzatti, Fabio C. S. Nogueira, Leticia Szadai, Istvan Balazs Nemeth, Henrik Ekedahl, David Fenyo, Gyorgy Marko-Varga
Summary: The MM500 meta-study aims to establish a knowledge basis of the tumor proteome as a complement to genome and transcriptome studies. By analyzing 505 well-annotated melanoma tumor samples, the study defined the melanoma proteome landscape, including thousands of proteins and mutated proteoforms. The study found a high degree of correlation between the melanoma transcriptome and proteome, increasing understanding of melanoma disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Giuseppe Bosso, Pablo Lanuza-Gracia, Sergio Pineiro-Hermida, Merve Yilmaz, Rosa Serrano, Maria A. Blasco
Summary: BRAF(V600E) mutation is common in cancer and its expression leads to DNA damage response, inflammation, and differential changes in cell cycle and senescence-associated proteins in lung epithelia.
CELL DEATH & DISEASE
(2022)
Article
Biology
Robert L. Bowman, Rebecca C. Hennessey, Tirzah J. Weiss, David A. Tallman, Emma R. Crawford, Brandon M. Murphy, Amy Webb, Souhui Zhang, Krista Md La Perle, Craig J. Burd, Ross L. Levine, A. Hunter Shain, Christin E. Burd
Summary: This study demonstrates that a single UVB exposure results in a greater burden of mutations in murine tumors driven by oncogenic Braf, with mutational signatures mirroring those associated with human skin cancer.
LIFE SCIENCE ALLIANCE
(2021)
Article
Pharmacology & Pharmacy
Jessica R. Spengler, Stephen R. Welch, Jana M. Ritter, Jessica R. Harmon, JoAnn D. Coleman-McCray, Sarah C. Genzer, Josilene N. Seixas, Florine E. M. Scholte, Katherine A. Davies, Steven B. Bradfute, Joel M. Montgomery, Christina F. Spiropoulou
Summary: Lethal models of Ebola virus disease have been developed using virus isolates from human cases in mice and guinea pigs. However, the use of non-adapted virus in mice has been limited due to the absence of overt clinical disease. Recently recognized sequelae in human cases emphasize the importance of investigating non-lethal infection in both humans and animal models.
ANTIVIRAL RESEARCH
(2023)
Article
Oncology
Ishani Banik, Phil F. Cheng, Christopher M. Dooley, Jana Travnickova, Munise Merteroglu, Reinhard Dummer, Elizabeth E. Patton, Elisabeth M. Busch-Nentwich, Mitchell P. Levesque
Summary: The study demonstrates that activating the P38 alpha-MAPK14 pathway can inhibit the onset of NRAS-mutant melanoma, indicating a potential biological difference between BRAF and NRAS mutations in melanoma. The translational benefit of the study is highlighted by the use of anisomycin to activate the pathway, showing promise for clinical applications.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Genetics & Heredity
Gerardo Cazzato, Katia Mangialardi, Giovanni Falcicchio, Anna Colagrande, Giuseppe Ingravallo, Francesca Arezzo, Giovanna Giliberti, Irma Trilli, Vera Loizzi, Teresa Lettini, Sara Scarcella, Tiziana Annese, Paola Parente, Carmelo Lupo, Nadia Casatta, Eugenio Maiorano, Gennaro Cormio, Leonardo Resta, Domenico Ribatti
Summary: The use of PRAME as a tumor marker holds potential value in the diagnosis and immunotherapeutic approach to cancer. However, its specificity is lower and it may also be expressed in atypical lesions.
Article
Oncology
Ishani Banik, Phil F. Cheng, Christopher M. Dooley, Jana Travnickova, Munise Merteroglu, Reinhard Dummer, Elizabeth E. Patton, Elisabeth M. Busch-Nentwich, Mitchell P. Levesque
Summary: The study demonstrates that activating the P38 alpha-MAPK14 pathway can effectively suppress the initiation and growth of NRAS-mutant melanoma, and reduce the viability of MEK inhibitor resistant melanoma cells. These findings suggest a biological difference between BRAF and NRAS-mutant melanoma.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Genetics & Heredity
Courtney K. Wallingford, Hannah Kovilpillai, Chris Jacobs, Erin Turbitt, Clare A. Primiero, Mary-Anne Young, Deanna G. Brockman, H. Peter Soyer, Aideen M. McInerney-Leo, Tatiane Yanes
Summary: This study reviewed current models for communicating polygenic scores (PGS) and psycho-behavioral outcomes. A total of 28 articles representing 17 studies were included. The study found limited consistency in PGS communication and evaluation of outcomes. Most studies presented risk in multiple ways and provided personalized lifestyle advice. The findings suggest the need for standardized guidelines and evidence-based interventions informed by behavior change theories.
GENETICS IN MEDICINE
(2023)
Article
Dermatology
Caitlin Horsham, Monika Janda, Melissa Kerr, H. Peter Soyer, Liam J. Caffery
Summary: In this study, a virtual consumer forum was conducted to assess patient's concerns about privacy and confidentiality in dermatology imaging for research, artificial intelligence development, and clinical care. The concerns of patients regarding the use and confidentiality of skin imaging in these different scenarios were examined. The use of 3D total-body photography for early detection of melanoma is not widespread in clinical practice, hence a comprehensive understanding of patient's concerns is lacking.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Liam J. Caffery, Monika Janda, Robert Miller, Lisa M. Abbott, Chris Arnold, Tony Caccetta, Pascale Guitera, Stephen Shumack, Pablo Fernandez-Penas, Victoria Mar, H. Peter Soyer
Summary: This article presents the position statement of the Australasian College of Dermatologists on the use of AI in dermatology and provides explanatory information that was used to inform the development of this statement.
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Dilki Jayasinghe, Uyen Koh, Elsemieke Plasmeijer, Scott W. Menzies, Joanne F. Aitken, H. Peter Soyer, Monika Janda, Adele C. Green, Brigid Betz-Stablein
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Te Wai Pounamu T. Hona, Caitlin Horsham, Carina V. Silva, Craig Lawn, Saira Sanjida, Nicole Gillespie, H. Peter Soyer, Monika Janda, ACEMID Grp
Summary: A cross-sectional survey conducted in Australia found that most participants displayed positive attitudes towards 3D total-body photography and were willing to use it for monitoring and identifying skin lesions. Participants believed that this technology could effectively identify suspicious spots, monitor lesion changes, and reduce anxiety. However, potential barriers such as cost, accessibility, trust, and digital security concerns need to be addressed. Overall, participants showed a high level of acceptance and confidence in the technology.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Dilki Jayasinghe, Brigid Betz-Stablein, Mitchell S. Stark, H. Peter Soyer, Monika Janda
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
Meghan E. Muse, Helmut Schaider, Harald Oey, H. Peter Soyer, Brock C. Christensen, Mitchell S. Stark
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Paras P. Mehta, Mary Sun, Brigid Betz-Stablein, Allan Halpern, Jochen Weber, Kivanc Kose, H. Peter Soyer, Veronica Rotemberg
Summary: The objective of this study was to compare the performance of an artificial intelligence model trained on a standard adult-predominant dermoscopic dataset before and after the addition of additional pediatric training images. Two models were trained: one on an adult-predominant dataset and the other on additional pediatric images. The performance of the models was compared using adult and pediatric test images. Adding pediatric training images improved algorithm performance on pediatric images without diminishing performance on adult images, demonstrating the importance of diverse data for improving the generalizability of AI models for dermatology.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Letter
Dermatology
M. Claeson, S. X. Tan, D. Lambie, S. Brown, M. D. Walsh, P. D. Baade, N. Pandeya, K. J. Whitehead, H. P. Soyer, B. M. Smithers, D. C. Whiteman, K. Khosrotehrani
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Austen Anderson, Fiona Bruce, H. Peter Soyer, Crystal Williams, Rebecca B. Saunderson
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Medicine, Research & Experimental
Mabel K. Yan, Anne E. Cust, H. Peter Soyer, Monika Janda, Katja Loewe, Gabrielle Byars, Paul Fishburn, Paul White, Rashidul Alam Mahumud, Robyn P. M. Saw, Alan Herschtal, Pablo Fernandez-Penas, Pascale Guitera, Rachael L. Morton, John Kelly, Rory Wolfe, Victoria J. Mar
Summary: This study aims to evaluate the clinical impact and cost-effectiveness of using Melanoma surveillance photography (MSP) for individuals at ultra-high or high risk of melanoma. The study is a randomized controlled trial (RCT) conducted over 3 years, with 580 participants from three Australian states. The primary outcome measure is the number of unnecessary biopsies, and secondary outcomes include health economic outcomes, quality of life, and patient acceptability. The results of this study will contribute to policy decision-making and the clinical application of MSP.
Article
Multidisciplinary Sciences
Ho Yi Wong, Ruby C. Lee, Sharene Chong, Stuti Kapadia, Michael Freeman, Valentine Murigneux, Susan Brown, H. Peter Soyer, Edwige Roy, Kiarash Khosrotehrani
Summary: This study suggests that mutation burden is strongly associated with the burden of keratinocyte skin cancers (KCs) such as basal and squamous cell carcinomas. Accumulation of mutations and clonal expansion play a key role in the development of KCs. UV radiation, the main carcinogen for KCs, is linked to epidermal mutation load. Epidermal ablation, followed by spontaneous healing, can reduce mutation load and prevent subsequent KCs.
Article
Dermatology
Mitchell S. Stark, Richard A. Sturm, Yan Pan, Darren J. Smit, Varsha Kommajosyula, Katie J. Lee, Kasturee Jagirdar, Catriona McLean, David L. Duffy, H. Peter Soyer, Victoria J. Mar
Summary: This study performed a rare-variant allele analysis, identifying some genes associated with nodular melanoma (NM), including PTCH1, ARID2, and GHR. Rare variants in the SMO gene, which interacts with PTCH1, were also found, suggesting a potential contribution of the Hedgehog pathway to NM risk.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Siyuan Yan, Zhen Yu, Xuelin Zhang, Dwarikanath Mahapatra, Shekhar S. Chandra, Monaca Janda, Peter Soyer, Zongyuan Ge
Summary: In this paper, the authors propose a human-in-the-loop framework to address the problem of deep neural networks relying on confounding factors. Their method automatically discovers confounding factors and allows human users to intervene using explainable concept spaces, improving the performance and trustworthiness of the model during inference.
2023 IEEE/CVF CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CVPR)
(2023)
Article
Dermatology
Nirmala Pandeya, Nancy Huang, Zainab Jiyad, Elsemieke Plasmeijer, Mandy Way, Nicole Isbel, Scott Campbell, Daniel C. Chambers, Peter Hopkins, H. Peter Soyer, David C. Whiteman, Catherine M. Olsen, Adele C. Green
Summary: Organ transplant recipients (OTRs) have a higher risk of basal cell carcinomas (BCCs) compared to the general population. There are some differences in the clinicopathologic features of BCCs between OTRs and the general population. Although aggressive subtypes of BCCs are less common in OTRs, BCCs that invade beyond the dermis are almost twice as prevalent in OTRs compared to the general population.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)