Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Oncology
Vidushi S. Neergheen, Annaelle Hip Kam, Yeshna Pem, Srishti Ramsaha, Theeshan Bahorun
Summary: The polysaccharides, polysaccharide-protein complexes, and low molecular weight secondary metabolites in mushrooms have received attention for their potential anti-cancer properties. These active compounds can inhibit tumor cell growth and enhance immune function. However, the underlying mechanisms are not fully understood and further research is needed.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Woonghee Lee, Gwonhwa Song, Hyocheol Bae
Summary: Recent studies have identified obesity as one of the world's most serious chronic disorders. The regulation of adipogenesis through inhibiting adipogenic differentiation and reactive oxygen species (ROS) production has been selected as a strategy to treat obesity. Fraxetin, a major component extracted from the stem barks of Fraxinus rhynchophylla, has many bioactivities. The effects of fraxetin on adipogenesis and ROS production involve mitogen-activated protein kinase (MAPK) signaling pathways.
Article
Food Science & Technology
Yu-Hsiang Yu, Yi-Han Lai, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
Summary: The study reveals that DON induces inflammation in porcine intestinal epithelial cells (IPEC-J2) through phosphorylation of MAPK signaling pathways. However, co-treatment with DON and lipopolysaccharide (LPS) does not further enhance the expression of inflammation and tight junction-associated genes. Mycotoxin adsorbent agents can attenuate DON-induced inflammatory responses in IPEC-J2 cells by modulating the phosphorylation of p38, ERK, and JNK.
Article
Veterinary Sciences
Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutani
Summary: The study revealed that African hedgehog adenovirus uses the p38 pathway for replication in infected cells and induces cytopathic effects. Inhibitors of the p38 pathway were effective in suppressing viral replication, but did not inhibit virus-induced cytopathic effects.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mengmeng Zhang, Shuqun Zhang
Summary: This review provides a historic and recent understanding of the role of mitogen-activated protein kinase (MAPK) cascades in plant immunity, response to environmental stresses, and normal growth and development. The signaling specificity of MAPKs in plants is an interesting topic of research and is influenced by factors such as activation kinetics, spatial and temporal expression patterns, and functional characterization of MAPK substrates.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irene Rodriguez, Ester Saavedra, Henoc del Rosario, Juan Perdomo, Jose Quintana, Filippo Prencipe, Paola Oliva, Romeo Romagnoli, Francisco Estevez
Summary: A chalcone compound containing an indole and a pyridine heterocyclic rings and an alpha-bromoacryloylamido radical was found to be a potent apoptotic inducer for human melanoma cell lines SK-MEL-1 and MEL-HO. The cell death mechanism involves the generation of reactive oxygen species, activation of apoptotic and MAPK pathways, upregulation of TRAIL, DR4 and DR5, downregulation of p21, and inhibition of the NF-κB pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Review
Immunology
Bo Yu, Yalong Zhang, Tianyu Wang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Tao Qiu
Summary: The mitogen-activated protein kinase (MAPK) signaling pathway, which can be triggered by various growth factors, cytokines, and hormones, plays a crucial role in regulating cellular activities such as cell proliferation, motility, and differentiation. It has been extensively studied in the context of inflammation and tumor development. Hepatic ischemia-reperfusion injury (HIRI) is a common pathological phenomenon occurring during surgical procedures like lobectomy and liver transplantation, characterized by severe inflammatory reaction following ischemia and reperfusion. This review mainly focuses on discussing the roles of p38, ERK1/2, JNK in the MAPK family, as well as TAK1 and ASK1 in the MAPKKK family, in HIRI, aiming to identify effective treatments for HIRI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Tae-Won Jang, Jae-Ho Park
Summary: The research demonstrated that the callus of Abeliophyllum distichum has anti-inflammatory effects by inhibiting the MAPK, PI3K/Akt, and NF-kappa B signaling pathways. The presence of acteoside and isoacteoside in CAO contributes to its potential as an anti-inflammatory agent by suppressing the release of inflammation factors in RAW 264.7 cells.
Article
Biochemistry & Molecular Biology
Hitesh Soni, Ravi Kumar, Praghalathan Kanthakumar, Adebowale Adebiyi
Summary: IL-1 beta induces Ca2+ entry via TRPA1 channels, leading to MAPK-dependent mesangial cell proliferation without stimulating fibronectin production.
Review
Oncology
Sunil Kumar Singh, Ruchi Roy, Sandeep Kumar, Piush Srivastava, Saket Jha, Basabi Rana, Ajay Rana
Summary: MAP4K4, a member of the MAPK signaling pathway, plays a crucial role in various non-malignant and malignant diseases. It has been implicated in metabolic and inflammatory diseases as well as glioblastoma, colon, prostate, and pancreatic cancers. Since MAP4K4 plays a significant role in inflammatory and malignant diseases, it can be targeted for therapeutic intervention.