Article
Nanoscience & Nanotechnology
Taoran Tian, Chong Zhao, Songhang Li, Zhiyin Huang, Yangkun Guo, Wenting Dai, Ruqiang Bai, Chengwei Tang, Yunfeng Lin, Jinhang Gao
Summary: This study established a new strategy to attenuate liver fibrosis by using a C-C chemokine receptor 2 (CCR2) small interfering RNA silencing (siCcr2)-based therapy loaded with a tetrahedron framework DNA nanostructure (tFNA) vehicle (tFNA-siCcr2).
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M. Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A. Wood, Yao-Ying Ma, X. Charlie Dong, Raghavendra G. Mirmira, Tao Lu
Summary: Dysregulation of metabolic functions in the liver affects the development of diabetes and metabolic disorders. The study identifies lysine demethylase 2A (KDM2A) as a negative regulator of nuclear factor (NF)-kappa B in the liver, with a crucial role in liver function. Through a liver-specific Kdm2a knockout mouse model, it is shown that KDM2A deficiency leads to liver dysfunction and increased inflammation.
Article
Immunology
Jing Huang, Lan Wang, Chuanfei Yu, Zhihao Fu, Chunyu Liu, Gang Wu, Luyun Guo, Xiao Guo, Shiyu Chen, Xumei Liu, Junzhi Wang
Summary: The developed U937 cell-based bioassay for measuring the biological activities of mAbs and biosimilars against TNF-α showed accuracy and precision in determining potency values, making it suitable for quality control and release of mAbs, as well as evaluating the similarity in biological activity of biosimilars.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Summary: MUC3A is highly expressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis, advanced staging, and low differentiation. Knockdown of MUC3A suppresses tumor growth and DNA damage repair pathways, suggesting it may be a potential oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Kuan Cao, Zhiyi Liu, Jin Liu, Qinghe Hu, Wengang Shan, Bin Hu, Hengliang Shi, Bin Zhang
Summary: COP1 is upregulated in liver cancer and its overexpression promotes liver cancer cell proliferation. COP1 interacts with IL1RAP and regulates mIL1RAP expression through K63-linked polyubiquitination. The COP1/IL1RAP/NF-kappa B axis promotes proliferation of liver cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo, Jie Jiang
Summary: This study identified a regulatory circuit linking NF-kappa B signaling and OVOL2 in the modulation of glucose metabolism in non-small cell lung cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Yangkun Guo, Chong Zhao, Wenting Dai, Bowen Wang, Enjiang Lai, Yang Xiao, Chengwei Tang, Zhiyin Huang, Jinhang Gao
Summary: This study investigates the mechanism by which CCR2 inhibition reduces extracellular matrix (ECM) accumulation and liver fibrosis. The results demonstrate that CCR2 inhibition can alleviate liver fibrosis by restoring the immune cell landscape and inhibiting profibrotic gene transcription through the STAT1/NF kappa B/ERK signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Fisheries
Juliette Schneider, Jean-Luc Imler
Summary: The fruitfly Drosophila melanogaster is a valuable model for studying innate immune mechanisms, especially in the context of viral infections. Research has uncovered the importance of RNA interference and inducible transcriptional responses in antiviral immunity in fruitflies. Recent discoveries of signaling pathways in fruitflies, such as the STING-IKK beta-Relish cassette, highlight the role of NF-kappa B transcription factors in controlling viral infections, in addition to bacterial and fungal infections.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Tong Yu, Yanyan Liu, Junwen Xue, Xiang Sun, Di Zhu, Lu Ma, Yingying Guo, Tongzhu Jin, Huiying Cao, Yingzhun Chen, Tong Zhu, Xuelian Li, Haihai Liang, Zhimin Du, Hongli Shan
Summary: This study found that Gankyrin is upregulated in non-small cell lung cancer (NSCLC) and plays a role in promoting cancer progression through the regulation of YAP1 and glycolysis. The inhibition of Gankyrin could potentially be a therapeutic strategy for NSCLC.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Xingyue Yang, Jing Dai, Shun Yao, Jiaxing An, Guorong Wen, Hai Jin, Li Zhang, Liming Zheng, Xingyue Chen, Zhiqiang Yi, Biguang Tuo
Summary: Liver cancer is a common type of cancer worldwide, with hepatitis B virus infection being a major risk factor. APOBEC3B, a cytosine deaminase, has been found to be upregulated in various types of tumors. This review explores the role of APOBEC3B in the development of liver cancer due to HBV infection, providing new directions and strategies for the treatment and prevention of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ho Am Jang, Bharat Bhusan Patnaik, Maryam Ali Mohammadie Kojour, Bo Bae Kim, Young Min Bae, Ki Beom Park, Yong Seok Lee, Yong Hun Jo, Yeon Soo Han
Summary: TmSpz-like, a cystine knot protein in T. molitor, plays a critical role in the innate immune response against E. coli infection by positively regulating AMP production and the expression of NF-κB-encoding genes. Its knockdown leads to downregulation of AMP-encoding genes and NF-κB expression, impacting the viability of infected larvae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hitha Gopalan Nair, Aneta Jurkiewicz, Damian Graczyk
Summary: Tumour necrosis factor alpha (TNF-alpha) is a multifunctional cytokine that plays a pivotal role in apoptosis, cell survival, inflammation, and immunity. While it is known for its antitumor properties, TNF-alpha also has tumor-promoting effects. This study shows that inhibiting RNA polymerase III (Pol III) enhances the cytotoxic and cytostatic effects of TNF-alpha in colorectal cancer cells, suggesting that targeting Pol III may be a potential therapeutic intervention to sensitize cancer cells to TNF-alpha.
Article
Cell Biology
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: This study revealed the crucial role of GOLPH3 in the development and progression of acute liver and kidney injury induced by endotoxemia. Upregulation of GOLPH3 was associated with high morbidity and mortality. Knockdown of GOLPH3 alleviated cellular stress response and inflammatory reaction, leading to the recovery of Golgi morphology and function. These findings suggest GOLPH3 as a potential therapeutic target for endotoxemia-induced tissue injury.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Shaniya Ahmad, Madiha Abbas, Mohammad Fahad Ullah, Moammir H. Aziz, Ozal Beylerli, Majid Ali Alam, Mansoor Ali Syed, Shahab Uddin, Aamir Ahmad
Summary: The role of long non-coding RNAs (lncRNAs) in cancer metastasis, particularly in the context of NF-kappa B signaling and epithelial-mesenchymal transition (EMT), is a hot topic of research. NKILA has emerged as a well-studied lncRNA that regulates NF-kappa B and inhibits EMT-induced metastasis. lncRNAs like FOXD2-AS1, KRT19P3, MALAT1, SNHG15, CRNDE, and AC007271.3 are also implicated in the regulation of NF-kappa B signaling and cancer metastasis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Min-Kyung Yeo, Yoonjoo Kim, Da Hye Lee, Chaeuk Chung, Go Eun Bae
Summary: This study found that the expression of NF-kappa B and AICDA increased in EGFR-TKI-resistant LAC, and the suppression of NF-kappa B and AICDA had a significant therapeutic effect in overcoming EGFR-TKI resistance.
Article
Oncology
Jianjun Wang, Feng Huang, Yaxiang Shi, Qinghui Zhang, Song Xu, Yongliang Yao, Runqiu Jiang
Summary: RP11-323N12.5 is the most up-regulated lncRNA in human gastric cancer, promoting YAP1 transcription by binding to c-MYC within the YAP1 promoter and exhibiting tumor-promoting and immunosuppressive effects. It serves as an ideal therapeutic target in human gastric cancer.
Editorial Material
Immunology
Zhongming Tan, Beicheng Sun
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Eman D. Mohammed, Ashraf B. Abdel-Naim, Jin Kangpeng, Runqiu Jiang, Jifu Wei, Beicheng Sun
Summary: Non-alcoholic fatty liver disease (NFLD) is a global public health issue with progression depending on patient lifestyle, while insulin resistance is a key factor leading to disease exacerbation. Glucosinolates (GLS), known for their potent anti-cancer effects, are recommended for experimental and clinical studies against a wide range of chronic liver diseases.
Article
Plant Sciences
Eman D. Mohammed, Zechuan Zhang, Wenfang Tian, Venkatanarayana Gangarapu, A. A. Al-Gendy, Jun Chen, Jifu Wei, Beicheng Sun
Summary: This study extracted a nitriles rich fraction (NRF) from Diceratella elliptica and demonstrated its potential to enhance insulin sensitivity, improve NASH histopathology, and act as an anti-NASH and anti-fibrotic agent.
Article
Cell Biology
Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia, Changtao Jiang, Wei Jia
Summary: This study reveals that high levels of hyocholic acid (HCA) in pigs contribute to their resistance against type 2 diabetes, as depletion of bile acids (BA) in pigs leads to reduced glucagon-like peptide-1 (GLP-1) secretion and increased blood glucose levels. HCA administration in diabetic mouse models effectively improves GLP-1 secretion and glucose homeostasis by activating TGR5 and inhibiting FXR in enteroendocrine cells, a mechanism not seen in other BA species. Clinical findings also show a correlation between lower levels of HCA species and diabetes, indicating its importance in glycemic control.
Review
Oncology
Jiajie Hou, Michael Karin, Beicheng Sun
Summary: The immune system plays crucial roles in cancer development and treatment, with adaptive immunity capable of preventing or constraining cancer and innate immunity and inflammation often promoting tumorigenesis. While immunotherapies derived from preclinical studies have shown efficacy in treating cancer, treatments targeting cancer-associated inflammation still require successful implementation. Anti-inflammatory agents have the potential to delay cancer onset and enhance the efficacy of conventional and next-generation cancer therapies.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Editorial Material
Cell Biology
Hua Su, Fei Yang, Beicheng Sun, Michael Karin
Summary: Inhibition of autophagy leads to upregulation of macropinocytosis (MP) in cancer cells, allowing them to overcome autophagy deficiency and sustain their bioenergetic demands. The NFE2L2/NRF2-driven induction of MP-related genes (MRGs) is responsible for the upregulation of MP in autophagy-inhibited, hypoxic, and oxidative-stress-exposed cancer cells. Simultaneous blockade of autophagy and MP effectively cuts off nutrient and supplies to cancer cells, leading to rapid tumor regression.
Article
Oncology
Hua Su, Fei Yang, Rao Fu, Xin Li, Randall French, Evangeline Mose, Xiaohong Pu, Brittney Trinh, Avi Kumar, Junlai Liu, Laura Antonucci, Jelena Todoric, Yuan Liu, Yinling Hu, Maria T. Diaz-Meco, Jorge Moscat, Christian M. Metallo, Andrew M. Lowy, Beicheng Sun, Michael Karin
Summary: Although many cancers rely on autophagy for nutrient acquisition, blocking autophagy alone does not effectively inhibit tumor growth. Research has shown that blocking autophagy can lead to pancreatic ductal adenocarcinoma (PDAC) upregulating an alternative nutrient pathway, macropinocytosis (MP), allowing tumor cells to extract nutrients from outside sources. This switch from autophagy to MP, driven by the activation of transcription factor NRF2, presents a potential therapeutic strategy for inhibiting tumor growth and regression.
Article
Immunology
Wenjie Zhang, Guangyan Zhangyuan, Fei Wang, Kangpeng Jin, Haiyuan Shen, Liansheng Zhang, Xiang Yuan, Jincheng Wang, Haitian Zhang, Weiwei Yu, Ruyi Huang, Xiaoliang Xu, Yin Yin, Guisheng Zhong, Anning Lin, Beicheng Sun
Summary: Chronic inflammation in hepatocellular carcinoma (HCC) is influenced by the zinc finger transcription factor Miz1, which restricts hepatocyte-driven inflammation through sequestration of the oncoprotein metadherin (MTDH) and prevention of NF-kappa B activation. Miz1 acts as a tumor suppressor by preventing a subset of hepatocytes from promoting inflammation in HCC, leading to disease recurrence and poor prognosis in patients.
Article
Biochemistry & Molecular Biology
Lu Liu, Xianfeng Cheng, Hui Yang, Senlin Lian, Yuegen Jiang, Jinhua Liang, Xiao Chen, Suo Mo, Yu Shi, Sishu Zhao, Jianyong Li, Runqiu Jiang, Dong-Hua Yang, Yujie Wu
Summary: BCL-2 expression in T cells of CLL patients is associated with immunosuppression through promoting regulatory T cell abundance and cytotoxic T lymphocyte exhaustion.
Article
Chemistry, Multidisciplinary
Pengkai Wu, Haitian Zhang, Yin Yin, Meiling Sun, Shuai Mao, Huihui Chen, Yexuan Deng, Shuai Chen, Shuo Li, Beicheng Sun
Summary: This study reports a novel delivery system, FEGCG/Zn, for immunotherapy of therapeutic biomolecules. The system integrates fluorination and zinc ions into epigallocatechin gallate (EGCG) to improve delivery efficiency. The results demonstrate that FEGCG/Zn regulates PD-L1 expression and improves immune-biomolecule delivery, offering a versatile platform for cancer immunotherapy.
Article
Gastroenterology & Hepatology
Suyavaran Arumugam, Binghua Li, Sri Lakshmi Tejaswi Boodapati, Michael H. Nathanson, Beicheng Sun, Xinshou Ouyang, Wajahat Z. Mehal
Summary: TGF-beta induces HSC transdifferentiation by releasing mitochondrial DNA and activating the cGAS-STING-IRF3 pathway.
Article
Biochemistry & Molecular Biology
Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang, Jing Xu, Hong Yang, Yuanchang Hu, Jiannan Qiu, Liyong Pu, Jinhai Tang, Xuehao Wang
Summary: YTHDF1 plays a key role in hepatocellular carcinoma, with its expression level correlated to hypoxia-induced autophagy, tumor growth, and metastasis, serving as an independent prognostic factor. HIF-1 alpha regulates YTHDF1 transcription under hypoxia to promote translation of autophagy-related genes, contributing to autophagy and malignancy in HCC progression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)