Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xin Lin, Kenji Tago, Nozomi Okazaki, Takanori So, Kyoko Takahashi, Tadahiko Mashino, Hiroomi Tamura, Megumi Funakoshi-Tago
Summary: In this study, the newly synthesized indole-hydantoin derivative IH-1 showed significant inhibitory effects on LPS-induced inflammatory responses in murine macrophage-like cells, indicating its potential as an anti-inflammatory drug.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shenglan Liu, Liangmei He, Junhong Wu, Xinqiang Wu, Lu Xie, Wei Dai, Lingxia Chen, Fuhua Xie, Zhiping Liu
Summary: DHX9 plays a crucial role in promoting proliferation and metastasis in colorectal cancer, making it a potential therapeutic target for prevention and treatment of CRC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhenlin Wang, Yuping Shi, Chenting Ying, Yang Jiang, Jiangfeng Hu
Summary: PLOD1 is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer, particularly associated with the progression of the most malignant mesenchymal subtype in GBM. Molecular experiments and tumor xenograft models demonstrated that PLOD1 overexpression promotes tumor viability, proliferation, migration, and mesenchymal transition, with an association to the NF-kappa B signaling pathway. High PLOD1 expression may be a potential treatment target for mesenchymal GBM or even all GBM by enhancing tumor invasiveness.
Article
Biochemistry & Molecular Biology
Serena Mirra, Laura Sanchez-Bellver, Carmela Casale, Alessandra Pescatore, Gemma Marfany
Summary: Activation of NF-kappa B transcription factor is regulated in the retina to prevent excessive inflammation. Downregulation of USP48 stabilizes NF-kappa B/p65 and increases its transcriptional activity in retinal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Inna Rabinovich-Nikitin, Alexandra Blant, Rimpy Dhingra, Lorrie A. Kirshenbaum, Michael P. Czubryt
Summary: Hypoxia has broad effects on cardiomyocyte function and viability, and this study reveals that the transcriptional coactivator PGC-1 alpha is down-regulated in hypoxia through the nuclear localization of NF-kappa B p65 subunit and its association with the PGC-1 alpha promoter.
Article
Pharmacology & Pharmacy
Bin Yang, Huijun Yang, Xiaomei Lu, Laiyuan Wang, Hongfan Li, Shufeng Chen, Xianqiang Wang, Chenyang Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: The study demonstrated that miR-520b is expressed in human atherosclerotic plaques and suppresses EC inflammation by down-regulating the NF-KB p65-ICAM1/VCAM1 axis, regulating the interaction between monocytes and ECs, and potentially serving as a therapeutic target for EC dysfunction and atherosclerosis.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Wenhui Zhao, Ting Lin, Ziyi Fang, Huilin Zhou, Yangguang Du, Hexu Han
Summary: This study found that NAT10 expression was significantly increased in hepatocellular carcinoma (HCC) tissues and was associated with worse prognosis in HCC patients. NAT10 overexpression promoted HCC cell proliferation and migration, potentially through the activation of the NF-KB signaling pathway. NAT10 also played a role in HCC drug resistance by promoting acetyl-NF-KB p65 (Lys310) formation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Gastroenterology & Hepatology
Lianrong Zhao, Di Wu, Qiao Qu, Zhilong Li, Hongzhuan Yin
Summary: This study reveals that KPNA1 is highly expressed in colon cancer and acts as a nuclear transport protein to promote the nuclear import of NF-kappa B p65, thereby activating the NF-kappa B signaling pathway and promoting colonic carcinogenesis.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Chemistry, Medicinal
Yishan Zhou, Bingling Zhong, Xiangjing Min, Ying Hou, Ligen Lin, Qin Wu, Jingshan Shi, Xiuping Chen
Summary: This study demonstrated that isobavachalcone (IBC) could ameliorate colitis in mice possibly through inhibition of NF-kappa B p65.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yeon-Mi Hong, Seo Yeon Min, Dayeong Kim, Subin Kim, Daekwan Seo, Kyoung Hwa Lee, Sang Hoon Han
Summary: miR-200b-3p and miR-200c-3p can reduce the expression of IE72 and HCMV viral load by binding to the 3' UTR of the UL123 gene, and they also interact with the NF-kappa B signaling pathway. This study provides insights into the mechanisms of controlling HCMV replication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Salma Aktar, Jun Arii, Lidya Handayani Tjan, Mitsuhiro Nishimura, Yasuko Mori
Summary: The study reveals that HHV-6A infection activates the NF-KB pathway through the U14 protein, leading to upregulation of proinflammatory cytokines and promoting viral replication. Inhibition of the NF-KB pathway affects HHV-6A replication, and the results indicate the functional role of HHV-6A U14 in host cell signaling, providing new insights into the pathogenesis and replication mechanisms of HHV-6A.
JOURNAL OF VIROLOGY
(2021)
Article
Integrative & Complementary Medicine
Yishan Zhou, Shuangli Xiang, Haoyi Zheng, Ying Hou, Ying Wang, Chuang-Chuang Li, Qin Wu, Jingshan Shi, Xiuping Chen
Summary: The inhibitory effect of neferine on colitis-associated colorectal cancer was investigated, revealing its potential role in regulating NF-kappa B and STAT3 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yu-fei Wang, Jin-yan Feng, Li-na Zhao, Man Zhao, Xian-fu Wei, Yu Geng, Hong-feng Yuan, Chun-yu Hou, Hui-hui Zhang, Guo-wen Wang, Guang Yang, Xiao-dong Zhang
Summary: Aspirin induces ferroptosis in liver cancer cells by inhibiting the transcription of SLC7A11 gene activated by NF-κB-p65. This finding provides a new strategy for the combination therapy of HCC using aspirin and ferroptosis inducer.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Chune Ren, Xue Han, Chao Lu, Tingting Yang, Pengyun Qiao, Yonghong Sun, Zhenhai Yu
Summary: Research has shown that FBXW2 plays a crucial role in regulating the degradation of p65, inhibiting breast tumor growth and affecting cell resistance to paclitaxel. Additionally, FBXW2 influences the stem cell characteristics of breast cancer by regulating the degradation of p65.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Matthew S. Brown, Haruko Okada, Manish Valiathan, Gregory E. Lakin
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2015)
Article
Surgery
Aaron M. Kearney, Matthew S. Brown, Hooman T. Soltanian
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2015)
Article
Surgery
Nicholas Satariano, Matthew S. Brown, Samantha Zwiebel, Bahman Guyuron
AESTHETIC SURGERY JOURNAL
(2015)
Article
Surgery
James R. Gatherwright, Matthew S. Brown, Kristopher M. Katira, David J. Rowe
AESTHETIC SURGERY JOURNAL
(2015)
Article
Dentistry, Oral Surgery & Medicine
Matthew S. Brown, Haruko Okada, Manish Valiathan, Gregory E. Lakin
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2015)
Article
Surgery
David E. Kurlander, Matthew S. Brown, Rodrigo A. Iglesias, Vikas Gulani, Hooman T. Soltanian
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2016)
Article
Surgery
Matthew Brown, Michelle Lee, Samantha Zwiebel, Paul Adenuga, Sima Molavi, Madhusudhana Gargesha, Davood Varghai, Bahman Guyuron
PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)
Article
Surgery
Ayesha Punjabi, Matthew Brown, Bahman Guyuron
PLASTIC AND RECONSTRUCTIVE SURGERY
(2016)
Article
Critical Care Medicine
Matthew Brown, Charles Yowler, Christopher Brandt
JOURNAL OF BURN CARE & RESEARCH
(2013)
Article
Critical Care Medicine
Matthew Brown, Tammy Coffee, Paul Adenuga, Charles J. Yowler
JOURNAL OF BURN CARE & RESEARCH
(2014)
Letter
Surgery
Matthew Brown, Bryan Armijo, Hirikati Nagaraj, Ali Totonchi
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2013)
Letter
Surgery
Matthew Brown, James Gatherwright, Kristopher Katira, David Rowe
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2014)
Article
Surgery
Matthew Brown, Bahman Guyuron
PLASTIC AND RECONSTRUCTIVE SURGERY
(2013)
Article
Surgery
Paul Adenuga, Matthew Brown, Deborah Reed, Bahman Guyuron
PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)
Article
Surgery
Matthew Brown, Paul Adenuga, Hooman Soltanian
PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)