Article
Cell Biology
Manuel Schmidt, Anja Weidemann, Christine Poser, Anne Bigot, Julia von Maltzahn
Summary: The study suggests that stimulation of non-canonical NF-kappa B signaling by LT beta R agonist may impact myogenic differentiation, muscle stem cell function, and regeneration of skeletal muscle. The findings indicate a significant direct crosstalk between canonical and non-canonical NF-kappa B signaling in myogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xia Zhao, Shengchen Wang, Xiaojing Li, Honggui Liu, Shiwen Xu
Summary: Cadmium exposure induced necrotic cell death and ion homeostasis imbalance in swine myocardium. Furthermore, Cd exposure increased LXA4 content, inhibited FPR2 expression, activated TGF-beta pathway, suppressed Nrf2 pathway, and activated NF-kappa B pathway. Cd exposure also increased the expressions of necroptosis-related genes.
Article
Biochemistry & Molecular Biology
EunJin Bang, Dae Hyun Kim, Hae Young Chung
Summary: This study shows that the PAR2 pathway plays a crucial role in skin photoaging, with inhibition of PAR2 effectively reducing inflammation and oxidative stress levels. PAR2 induces oxidative stress and inflammation through Akt-mediated phosphorylation of NF-kappa B and FoxO6, suggesting a key regulatory mechanism in ROS-mediated inflammatory response.
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rohit Arora, Kenny M. Van Theemsche, Samuel Van Remoortel, Dirk J. Snyders, Alain J. Labro, Jean-Pierre Timmermans
Summary: Members of the MRGPRs, a subfamily of GPCRs, are involved in regulating inflammation, with MRGPRD releasing IL-6 upon stimulation by beta-alanine through the IKK/NF-kappa B signaling pathway. Inhibitors can block IL-6 release. FBS dependency affects the basal activity of MRGPRD in an in vitro system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hui Shi, Yaoxiang Sun, Hongru Ruan, Cheng Ji, Jiahui Zhang, Peipei Wu, Linli Li, Chihan Huang, Yuanwang Jia, Xu Zhang, Wenrong Xu, Jiajia Jiang, Hui Qian
Summary: The study found that the anti-cancer drug DIM at therapeutic concentrations upregulated the expression of tumor-related factors in GC-MSCs and promoted the proliferation, invasion, and migration of gastric cancer cells, leading to tumor growth. This mechanism provides a new insight into anti-cancer drug resistance and suggests the need to adjust the chemotherapy regimen to minimize the side effects of drugs on targeted TME cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maud Michelet, Dulce Alfaiate, Brieux Chardes, Caroline Pons, Suzanne Faure-Dupuy, Thomas Engleitner, Rayan Farhat, Tobias Riedl, Anne-Flore Legrand, Roland Rad, Michel Rivoire, Fabien Zoulim, Mathias Heikenwalder, Anna Salvetti, David Durantel, Julie Lucifora
Summary: This study analyzed the effect of several innate immune stimulators on HDV replication in infected hepatocytes. The researchers found that immune-modulators triggering the NF-kappa B pathways can inhibit HDV replication and may be a potential therapeutic approach for chronically HBV/HDV-infected patients.
Article
Immunology
Thomas Riffelmacher, Daniel A. Giles, Sonja Zahner, Martina Dicker, Alexander Y. Andreyev, Sara McArdle, Tamara Perez-Jeldres, Esme van der Gracht, Mallory Paynich Murray, Nadine Hartmann, Alexei Tumanov, Mitchell Kronenberg
Summary: This study reveals that the LIGHT signal acts on neutrophils via LTβR to suppress cellular metabolic activation, thereby preventing exacerbated immune pathogenesis during colitis.
MUCOSAL IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jian Gong, HuanYu Gong, Yang Liu, XinLan Tao, Hao Zhang
Summary: Liver fibrosis is an inevitable stage in the development of chronic liver disease to cirrhosis. Interventional treatment and controlling the disease at this stage can reduce the incidence of liver cirrhosis. The expression of VDR in liver tissues of patients with liver fibrosis is negatively correlated with alpha-SMA, Col-1, and liver fibrosis stages. Calcipotriol, a VDR agonist, effectively reduces the degree of liver fibrosis by inhibiting the deposition of ECM and activation of HSCs.
Article
Immunology
Chang Chen, Jingya Gu, Jue Wang, Yu Wu, Aihua Yang, Tingting Chen, Tingting Zhou, Zhaoguo Liu
Summary: PSG attenuates liver injury and fibrosis induced by carbon tetrachloride, decreases collagen deposition, and inhibits inflammation. It acts by regulating SIRT3-mediated NF-kappa B P65 nuclear expression, providing a potential therapeutic strategy for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Xue Ma, Tomoko Ogawa, Zheng Tian, Ruirong Yi, Kang Tang, Kengo Saito, Sara Yatabe, Yoshifumi Ohno, Ryosuke Muroyama, Eiji Ido, Hisahiro Matsubara, Hiroshi Shirasawa
Summary: In this study, a recombinant SINV expressing fluorescent proteins was used to analyze SINV infection and replication. Results showed that SINV could infect and replicate in both cancer cells and normal cells, but only caused lytic infection in cancer cells. Dysregulation of PKR in cancer cells was found to be the determinant of SINV oncolysis.
ANTICANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Xiaobing Lin, Junhan Zhang, Decai Fan, Jiqin Hou, Hao Wang, Lin Zhu, Ruina Tian, Xiaofei An, Ming Yan
Summary: Frutescone O was found to inhibit LPS-induced inflammation by suppressing the secretion of nitric oxide, inducing inducible nitric oxide synthase, and expression of pro-inflammatory cytokines. Additionally, Frutescone O exerts anti-inflammatory effects by interfering with NF-kappa B and MAPK signaling pathways, and inhibiting Myd88 and iNOS expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jing Dai, Xue Li, Cai Wang, Shuxin Gu, Lei Dai, Jingyun Zhang, Yunxia Fan, Jing Wu
Summary: The study revealed that repeated sevoflurane exposure in developing rats may induce neuroinflammation and neurocognitive impairment through NF-kappa B-mediated pyroptosis activation. This suggests a potential therapeutic target in treating neuroinflammation following neonatal anesthesia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biology
Nicholas Sim, Yinghui Li
Summary: p52-induced ETS1 overexpression in glioma cells remodels the genome-wide regulatory network of p52 and ETS1 to transcriptionally drive cancer progression. Chronic inflammation promotes glioma progression by activating NF-kappa B signalling, which promotes cancer cell invasion and angiogenesis. Non-canonical NF-kappa B activation directly regulates p52 at the ETS1 promoter, leading to its overexpression and impacting the genomic landscape of ETS1 in a glioma-specific manner.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Dermatology
Jeffrey S. Pawlikowski, Claire Brock, Sheau-Chiann Chen, Lara Al-Olabi, Colin Nixon, Fiona McGregor, Simon Paine, Estelle Chanudet, Wendy Lambie, William M. Holmes, James M. Mullin, Ann Richmond, Hong Wu, Karen Blyth, Ayala King, Veronica A. Kinsler, Peter D. Adams
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2015)
Editorial Material
Oncology
Anna Vilgelm, Ann Richmond
Article
Cell Biology
Yee Mon Thu, Susan Kaye Van Riper, LeeAnn Higgins, Tianji Zhang, Jordan Robert Becker, Todd William Markowski, Hai Dang Nguyen, Timothy Jon Griffin, Anja Katrin Bielinsky
Article
Biochemistry & Molecular Biology
Jordan R. Becker, David Gallo, Wendy Leung, Taylor Croissant, Yee Mon Thu, Hai Dang Nguyen, Timothy K. Starr, Grant W. Brown, Anja-Katrin Bielinsky
NUCLEIC ACIDS RESEARCH
(2018)
Article
Oncology
Anna E. Vilgelm, Jeff S. Pawlikowski, Yan Liu, Oriana E. Hawkins, Tyler A. Davis, Jessica Smith, Kevin P. Weller, Linda W. Horton, Colt M. McClain, Gregory D. Ayers, David C. Turner, David C. Essaka, Clinton F. Stewart, Jeffrey A. Sosman, Mark C. Kelley, Jeffrey A. Ecsedy, Jeffrey N. Johnston, Ann Richmond
Editorial Material
Medicine, Research & Experimental
Chi Yan, Ann Richmond
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Genetics & Heredity
Yee Mon Thu
Article
Biochemistry & Molecular Biology
Chi Yan, Jinming Yang, Nabil Saleh, Sheau-Chiann Chen, Gregory D. Ayers, Vandana G. Abramson, Ingrid A. Mayer, Ann Richmond
Summary: The study identified that combining PI3K/mTOR inhibitors with paclitaxel can enhance response to immune checkpoint inhibitors, leading to a positive impact on breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Zoology
Yee Mon Thu, Lauren B. French, Bradley M. Hersh, Margaret K. Nelson, Lisa B. Whitenack
Summary: The study explores the incorporation of research opportunities into undergraduate curricula, using FSBio 201 as an example. While student feedback is mostly positive, areas for improvement in peer mentoring and teaching computer skills are identified.
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2021)
Review
Oncology
Kennady Bullock, Ann Richmond
Summary: The translation introduced the research progress of inhibiting MDSCs by blocking CXCR2 to enhance the response to immunotherapy. MDSCs are associated with poor responses to cancer therapy, while CXCR2 is a key factor in recruiting MDSCs to tumors.
Article
Oncology
Chi Yan, Sheau-Chiann Chen, Gregory D. Ayers, Caroline A. Nebhan, Joseph T. Roland, Vivian L. Weiss, Douglas B. Johnson, Ann Richmond
Summary: Resistance to BRAF/MEK-targeted therapy is common in melanoma patients with BRAF mutated tumors, and tumor cellularity is associated with immune cells and survival outcomes.
NPJ PRECISION ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhizhu Zhang, Ann Richmond, Chi Yan
Summary: Hyperactivation of PI3K/AKT/mTOR and MAPK/MEK/ERK signaling pathways is common in various cancers, and targeting these pathways may enhance the response to immune checkpoint inhibitors (ICIs) as a strategy to overcome resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chi Yan, Caroline A. Nebhan, Nabil Saleh, Rebecca Shattuck-Brandt, Sheau-Chiann Chen, Gregory D. Ayers, Vivian Weiss, Ann Richmond, Anna E. Vilgelm
Summary: Humanized PDX mouse models with reduced development of GVHD were generated, allowing for preclinical trials with immune checkpoint inhibitors.
Article
Oncology
Verra M. Ngwa, Deanna N. Edwards, Yoonha Hwang, Breelyn Karno, Xiaoyong Wang, Chi Yan, Ann Richmond, Dana M. Brantley-Sieders, Jin Chen
Summary: The metabolism of glutamine in tumor endothelium plays a crucial role in tumor growth and metastasis. Inhibiting glutamine metabolism can normalize tumor vessels, reduce tumor growth and metastasis, improve perfusion, reduce hypoxia, and enhance chemotherapeutic drug delivery.
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Jinming Yang, Chi Yan, Anna E. Vilgelm, Sheau-Chiann Chen, Gregory D. Ayers, Christopher A. Johnson, Ann Richmond
Summary: The inhibition of the CXCR2 signaling pathway can reduce the number of MDSC in the tumor microenvironment, increase CXCL11-expressing B1b cells, and subsequently promote the infiltration and activation of effector CD8(+) T cells in tumors.
CANCER IMMUNOLOGY RESEARCH
(2021)