Article
Medicine, Research & Experimental
Akiko Inujima, Keiichi Koizumi, Naotoshi Shibahara
Summary: Research on bioactive components of herbal medicines has traditionally focused on secondary metabolites of herbal plants, with limited information on primary metabolites. This study highlights the immunostimulatory effects of heat-resistant RNA in a decoction of Glycyrrhizae Radix, suggesting nucleic acids as a new research field in the bioactive components of herbal medicines. By activating specific pathways and inducing cytokine production, the RNA demonstrated potential for therapeutic applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Hong Zhu, Yanan Jiang, Yue Guo, Jianbin Huang, Minghan Zhou, Yanyan Tang, Jiongming Sui, Jingshan Wang, Lixian Qiao
Summary: The novel WRKY gene AhWRKY75 enhances salt tolerance in transgenic peanut plants by improving the efficiency of the ROS scavenging system and photosynthesis under stress treatment. This study identifies a new mechanism for enhancing salt tolerance in peanut and other plants.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Reda F. A. Abdelhameed, Amany K. Ibrahim, Mahmoud A. Elfaky, Eman S. Habib, Mayada Mahamed, Eman T. Mehanna, Khaled M. Darwish, Dina M. Khodeer, Safwat A. Ahmed, Sameh S. Elhady
Summary: Cynanchum acutum L. is a climbing vine in the Apocynaceae family, and seven compounds were isolated from its methanolic extract, including six flavonoids with anti-inflammatory and antioxidant properties. Among them, quercetin-3-O-galactoside and quercetin demonstrated superior anti-inflammatory activity compared to other bioactive metabolites.
Article
Pharmacology & Pharmacy
Duygu Kose, Harun Un, Rustem Anil Ugan, Zekai Halici, Elif Cadirci, Tugba Bal Tastan, Aysenur Kahramanlar
Summary: The study revealed that treatment with aprepitant in rats with an experimental polymicrobial sepsis model led to increased levels of GSH and SOD activity, and decreased levels of MDA, TNF-alpha, and NFK-b expression, especially in the CLP + APRE40 group. The histopathology results supported the molecular and biochemical findings.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Immunology
Dmitry Kopelyanskiy, Chantal Desponds, Florence Prevel, Matteo Rossi, Romain Migliorini, Tiia Snaka, Remzi Onur Eren, Stephanie Claudinot, Lon-Fye Lye, Manolis Pasparakis, Stephen M. Beverley, Nicolas Fasel
Summary: Inducible nitric oxide synthase (iNOS) is involved in the control of intracellular human pathogens. Leishmania protozoan parasites carrying Leishmania RNA virus 1 (LRV1) induce low levels of iNOS and nitric oxide (NO), which fail to control infection. The induction of iNOS requires strong activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) triggered by LRV1-induced type I interferon (IFN). LRV1-bearing Leishmania parasites limit iNOS production by suppressing NF-kappa B activation. LRV1-induced iNOS may contribute to parasite metastasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Rafael Renatino Canevarolo, Nathalia Moreno Cury, Jose Andres Yunes
Summary: Acute lymphoblastic leukemia (ALL) is a common childhood cancer with high relapse rate due to drug resistance. Methotrexate (MTX) is commonly used but its mechanism and resistance are complex. This study found that the TNF-alpha signaling pathway via the NF-kappa B pathway is the most enriched cancer hallmark in MTX-poor-responder patients.
Article
Biotechnology & Applied Microbiology
Yujin Yuan, Xin Xu, Yingqing Luo, Zehao Gong, Xiaowei Hu, Mengbo Wu, Yudong Liu, Fang Yan, Xiaolan Zhang, Wenfa Zhang, Yuwei Tang, Bihong Feng, Zhengguo Li, Cai-Zhong Jiang, Wei Deng
Summary: Tomato trichomes serve as mechanical and chemical barriers against herbivores, and auxin treatment can increase the formation of specific types of trichomes on tomato leaves. Genes SlARF4, SlTHM1, and SlMYB52 play crucial roles in regulating trichome formation and providing tolerance to spider mites in tomato plants. The interplay between these genes and cyclin gene SlCycB2 modulates the formation of trichomes in tomato leaves through the R2R3 MYB-dependent auxin signaling pathway.
PLANT BIOTECHNOLOGY JOURNAL
(2021)
Article
Pathology
Takao Kondo, Yuto Otsuka, Hiromasa Aoki, Yoh Goto, Yohei Kawaguchi, Yuko Waguri-Nagaya, Ken Miyazawa, Shigemi Goto, Mineyoshi Aoyama
Summary: The study revealed the significant role of inducible nitric oxide synthase (iNOS) in osteoclast (OC) differentiation under hypoxia, and nitric oxide plays a regulatory role in OC formation.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Stierschneider, Petra Gruenstaeudl, Katrin Colleselli, Josef Atzler, Christian T. Klein, Harald Hundsberger, Christoph Wiesner
Summary: The study engineered a new optogenetic cell line that can activate NF-kappa B and ERK1/2 signaling pathways upon blue light exposure, providing spatial and temporal control over cellular activity. Light exposure enhanced cell attachment, invadopodia formation, and cell migration in 3D cultures, but did not significantly impact proliferation or viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Won-Gun Kwack, Yoon-Je Lee, Eun-Young Eo, Jin-Haeng Chung, Jae-Ho Lee, Young-Jae Cho
Summary: The study found that simultaneous pretreatment with enteral administration of aspirin and omega-3 fatty acid could alleviate lung injury and reduce inflammatory response in a murine VILI model. This combined pretreatment method may become a preventive strategy for VILI in critically ill patients undergoing mechanical ventilation therapy.
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Maha H. Sharawy, Dalia H. El-Kashef, Ahmed A. Shaaban, Dina S. El-Agamy
Summary: This study demonstrated the hepatoprotective activity of sitagliptin against Con A-induced hepatic fibrosis, potentially through enhancement of the Nrf2 signaling pathway and inhibition of NF-Kappa B. Sitagliptin may be a new candidate for suppressing hepatitis-associated fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Yi-Jung Li, Jiun-Wen Wang, Hsin-Hsu Wu, Hsu-Han Wang, Yang-Jen Chiang, Huang-Yu Yang, Hsiang-Hao Hsu, Chih-Wei Yang, Ya-Chung Tian
Summary: Inhibition of TNF-alpha can attenuate the inflammatory response and viral replication induced by BKPyV infection, providing a potential therapeutic target for BKPyV-associated kidney damage.
Article
Agricultural Engineering
Xiao Li, Yiyao Hou, Mingna Li, Fan Zhang, Fengyan Yi, Junmei Kang, Qingchuan Yang, Ruicai Long
Summary: This study revealed that an HD-Zip I transcription factor (MsHB7) in alfalfa plays a crucial negative regulatory role in response to salt stress. MsHB7 enhances the salt sensitivity in alfalfa by suppressing the expressions of ABA-responsive and antioxidant enzyme coding genes. These findings contribute to a better understanding of the gene regulation mechanism in alfalfa and provide important strategies for breeding salt-tolerant varieties.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Nathaniel Robichaud, Nahum Sonenberg, Davide Ruggero, Robert J. Schneider
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Nina Ripin, Julien Boudet, Malgorzata M. Duszczyk, Alexandra Hinniger, Michael Faller, Miroslav Krepl, Abhilash Gadi, Robert J. Schneider, Jiri Sponer, Nicole C. Meisner-Kober, Frederic H. -T. Allain
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Steven P. Daniels, Andrew D. Schweitzer, Robert Schneider, J. Levi Chazen
AMERICAN JOURNAL OF ROENTGENOLOGY
(2019)
Article
Cell & Tissue Engineering
Christina C. Spevak, Harold K. Elias, Lavanya Kannan, Mohamed A. E. Ali, Gaelle H. Martin, Shanmugapriya Selvaraj, William S. Eng, Amanda Ernlund, Vinagolu K. Rajasekhar, Carolien M. Woolthuis, Guangjie Zhao, Caryn J. Ha, Robert J. Schneider, Christopher Y. Park
Review
Biochemistry & Molecular Biology
Tiffany J. Rios-Fuller, Melanie Mahe, Beth Walters, Dounia Abbadi, Sandra Perez-Baos, Abhilash Gadi, John J. Andrews, Olga Katsara, C. Theresa Vincent, Robert J. Schneider
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Lee-or Herzog, Beth Walters, Roberta Buono, J. Scott Lee, Sharmila Mallya, Amos Fung, Honyin Chiu, Nancy Nguyen, Boyang Li, Anthony B. Pinkerton, Michael R. Jackson, Robert J. Schneider, Ze'ev A. Ronai, David A. Fruman
Summary: This study identified that using SBI-756 in lymphoma cells can synergize with Venetoclax to induce apoptosis, enhancing its efficacy. SBI-756 prevents eIF4E-eIF4G1 association and cap-dependent translation, reducing protein synthesis rates and selectively affecting sensitive cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Medical Laboratory Technology
Nitza Burck, Tal Gilboa, Abhilash Gadi, Michelle Patkin Nehrer, Robert J. Schneider, Amit Meller
Summary: The research presents a rapid nanopore genotyping strategy using solid-state nanopores for identification and classification of ctDNA mutations without amplification. It can effectively detect breast cancer mutations, offering a high sensitivity, multiplexing capability, and low cost approach for early cancer diagnosis.
CLINICAL CHEMISTRY
(2021)
Article
Biology
Maud Voisin, Elina Shrestha, Claire Rollet, Cyrus A. Nikain, Tatjana Josefs, Melanie Mahe, Tessa J. Barrett, Hye Rim Chang, Rachel Ruoff, Jeffrey A. Schneider, Michela L. Garabedian, Chris Zoumadakis, Chi Yun, Bara Badwan, Emily J. Brown, Adam C. Mar, Robert J. Schneider, Ira J. Goldberg, Ines Pineda-Torra, Edward A. Fisher, Michael J. Garabedian
Summary: The study demonstrates that reducing phosphorylation at serine 196 of LXR alpha in hematopoietic cells can attenuate atherosclerosis and obesity induced by a high-fat diet in mice by reprogramming the transcriptional activity of LXR alpha in macrophages and T cells to promote an anti-inflammatory phenotype.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Matthias A. Karajannis, Audrey Mauguen, Ekrem Maloku, Qingwen Xu, Erin M. Dunbar, Scott R. Plotkin, Anna Yaffee, Shiyang Wang, J. Thomas Roland, Chandranath Sen, Dimitris G. Placantonakis, John G. Golfinos, Jeffrey C. Allen, Nicholas A. Vitanza, Luis A. Chiriboga, Robert J. Schneider, Jingjing Deng, Thomas A. Neubert, Judith D. Goldberg, David Zagzag, Filippo G. Giancotti, Jaishri O. Blakeley
Summary: Inhibition of mTORC1 signaling with everolimus showed limited antitumor effect in patients with NF2, potentially due to incomplete inhibition of mTORC1 and downstream signaling. These findings provide insights for the design of future studies targeting mTORC1 in meningiomas and schwannomas.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Viviana Volta, Sandra Perez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider
Summary: The differentiation of Treg cells requires non-canonical mRNA translation mechanism involving DAP5 and eIF3d, facilitated by TGF-beta-1 and downregulation of mTORC1 activity.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Cell Biology
Chandan Kumar-Sinha, Arul M. Chinnaiyan
Summary: In breast cancer, the leucyl-tRNA synthetase LARS suppresses transformation and tumour development by increasing tRNA-Leu(CAG) translation of certain tumour suppressor mRNAs.
NATURE CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Preeyam S. Patel, Sandra Perez-Baos, Beth Walters, Margo Orlen, Angelina Volkova, Kelly Ruggles, Christopher Y. Park, Robert J. Schneider
Summary: This article explores the translational regulation of T cells and discovers a previously unknown mechanism of selective mRNA translation in T follicular helper cells (TFH cells). The study demonstrates that this translation mechanism is essential for TFH cell fate-specification and their role in autoimmune pathogenesis.
Article
Biochemistry & Molecular Biology
Mohammad Sadic, William M. Schneider, Olga Katsara, Gisselle N. Medina, Ashley Fisher, Aishwarya Mogulothu, Yingpu Yu, Meigang Gu, Teresa de Los Santos, Robert J. Schneider, Meike Dittmann
Summary: DDX60, an interferon-stimulated helicase, selectively reduces translation from certain viral IRESs to inhibit viral replication.
Article
Cell Biology
Amandine Alard, Olga Katsara, Tiffany Rios-Fuller, Columba de la Parra, Ugur Ozerdem, Amanda Ernlund, Robert J. Schneider
Summary: Cancer cell plasticity enables cell survival and fate transitions, such as epithelial-to-mesenchymal transition (EMT), which are essential for invasion and metastasis. The DAP5/eIF3d complex plays a crucial role in metastasis, EMT, and tumor directed angiogenesis by selectively translating mRNAs encoding EMT transcription factors, cell migration integrins, metalloproteinases, and cell survival and angiogenesis factors. These findings reveal a surprising level of plasticity in mRNA translation during cancer progression and metastasis.
Article
Biochemistry & Molecular Biology
Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S. W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman