期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 89, 期 6, 页码 911-914出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2010.355
关键词
-
资金
- Canadian Institute of Health Research
Isoniazid (INH)-induced hepatotoxicity remains a significant clinical problem, and the current mechanistic hypothesis is incomplete; it is simply referred to as metabolic idiosyncrasy, 1 which is believed to involve cytotoxicity caused by bioactivation of acetylhydrazine, 2 a metabolite of INH. However, this hypothesis is based on animal studies, involving characteristics that are very different from those that pertain to hepatotoxicity in humans, such as delayed onset. This issue therefore deserves a fresh look.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据