Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective

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(2016)   FUNDAMENTAL & CLINICAL PHARMACOLOGY

In Vitro Screening of 50 Highly Prescribed Drugs for Thiol Adduct FormationComparison of Potential for Drug-Induced Toxicity and Extent of Adduct Formation

(2009) Jinping Gan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

(2009) Chi Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Utilizing the Molecular Gateway: The Path to Personalized Cancer Management

(2009) J. B. Overdevest et al.   CLINICAL CHEMISTRY

Metabolite Identification and Profiling in Drug Design: Current Practice and Future Directions

(2009) Zhoupeng Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

Drug Metabolism and Pharmacokinetics in Support of Drug Design

(2009) Wei Tang et al.   CURRENT PHARMACEUTICAL DESIGN

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Immune mediation of hypersensitivity adverse drug reactions: implications for therapy

(2009) Michael J Rieder   Expert Opinion On Drug Safety

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-Throughput Screening and Characterization of Reactive Metabolites Using Polarity Switching of Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry

(2008) Bo Wen et al.   ANALYTICAL CHEMISTRY

The Discovery of Taranabant, a Selective Cannabinoid‐1 Receptor Inverse Agonist for the Treatment of Obesity

(2008) William K. Hagmann   ARCHIV DER PHARMAZIE

Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity

(2008) Danyelle M. Townsend et al.   BIOMEDICINE & PHARMACOTHERAPY

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Peptide-Based In Vitro Assay for the Detection of Reactive Metabolites

(2008) Michael D. Mitchell et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Immune-Mediated Adverse Drug Reactions

(2008) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY

Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose

(2008) LP James et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The State of Innovation in Drug Development

(2008) I Kola   CLINICAL PHARMACOLOGY & THERAPEUTICS

Obstacles and Opportunities in New Drug Development

(2008) KI Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

Recent Advances in High Throughput Screening for ADME Properties

(2008) Timothy Carlson et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery

(2008) Chandra Prakash et al.   CURRENT DRUG METABOLISM

Targeted Drugs and Nanomedicine: Present and Future

(2008) Paul Debbage   CURRENT PHARMACEUTICAL DESIGN

The heterozygous Sod2+/− mouse: modeling the mitochondrial role in drug toxicity

(2008) Urs A. Boelsterli et al.   DRUG DISCOVERY TODAY

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

(2008) H. Takakusa et al.   DRUG METABOLISM AND DISPOSITION

Detection of Novel Reactive Metabolites of Trazodone: Evidence for CYP2D6-Mediated Bioactivation of m-Chlorophenylpiperazine

(2008) B. Wen et al.   DRUG METABOLISM AND DISPOSITION

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

(2008) J. N. Bauman et al.   DRUG METABOLISM AND DISPOSITION

Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States

(2008) Naga Chalasani et al.   GASTROENTEROLOGY

Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases

(2008) Allen D. Brinker et al.   HEPATOLOGY

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV

(2008) Erik De Clercq   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population

(2008) Krishnan Bhaskaran   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS

(2008) Jinchun Sun et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Progress in Brain Penetration Evaluation in Drug Discovery and Development

(2008) X. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Glutathione in liver diseases and hepatotoxicity

(2008) Liyun Yuan et al.   MOLECULAR ASPECTS OF MEDICINE

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry

(2008) Heng-Keang Lim et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology

(2008) Burkhard Hinz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: A case study with melanocortin-4 receptor agonists

(2008) W. Tang et al.   XENOBIOTICA

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran

(2007) Kerstin Kenne et al.   TOXICOLOGY IN VITRO