Review
Veterinary Sciences
Michaela J. Beasley, Andy Shores
Summary: This article discusses the many non-infectious inflammatory diseases that affect the nervous system in canine patients, which are assumed to be immune-mediated. It focuses on the treatment medications for meningoencephalomyelitis of unknown origin, including their adverse effects, therapeutic monitoring, and effectiveness. The use of a steroid/ Cytosar((R)) or steroid/ cyclosporine treatment protocol is strongly supported by the literature, with the steroid tapered after the acute phase of the disease. The decision on tapering the steroid is dependent on the clinician, as best practices have not been established.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Oncology
Benoit Pilmis, Yousra Kherabi, Pauline Huriez, Jean-Ralph Zahar, Djamel Mokart
Summary: Targeted therapies have revolutionized cancer management, but they come with numerous infectious complications. This review highlights the main infectious complications associated with different targeted therapies and emphasizes the importance of identifying at-risk patients and implementing appropriate strategies to prevent or treat these complications.
Article
Oncology
Laura Moi, Hasna Bouchaab, Nuria Mederos, Tu Nguyen-Ngoc, Matthieu Perreau, Craig Fenwick, Julien Vaucher, Christine Sempoux, Solange Peters, Michel Obeid
Summary: The study found that targeted therapy focusing on T cells, such as using the IL-6 receptor-neutralizing antibody tocilizumab, can effectively alleviate the severity of the disease in patients with CS-refractory irCH, showing promising therapeutic potential. However, further validation in a larger patient population is necessary.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Immunology
David S. Hong, Ajay K. Gopal, Alexander N. Shoushtari, Sandip P. Patel, Aiwu R. He, Toshihiko Doi, Suresh S. Ramalingam, Amita Patnaik, Shahneen Sandhu, Ying Chen, Craig B. Davis, Timothy S. Fisher, Bo Huang, Kolette D. Fly, Antoni Ribas
Summary: This study aimed to estimate the objective response rate of utomilumab in patients with immune checkpoint inhibitor-refractory melanoma and non-small-cell lung cancer. The results showed that utomilumab had good tolerability but low antitumor activity. Efficacy was associated with immune-active tumor microenvironments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anusha Shirwaikar Thomas, Seung Eun Lee, Malek Shatila, Enrico N. De Toni, Helga-Paula Toeroek, Najib Ben Khaled, Nicholas Powell, Ryan Weight, David M. Faleck, Yinghong Wang
Summary: This study evaluated the efficacy of ustekinumab in treating immune checkpoint inhibitor-mediated colitis refractory to steroids plus infliximab and/or vedolizumab.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Shasha Guan, Linlin Zhang, Junyan Zhang, Wenjing Song, Diansheng Zhong
Summary: The use of immune checkpoint inhibitors in cancer treatment can lead to immune-related adverse events, one of which is bullous pemphigoid (BP). This study describes a 69-year-old lung squamous cell carcinoma patient who developed multiple vesicles and tense bullae after receiving a PD-1 inhibitor and chemotherapy. Biopsy confirmed the diagnosis of PD-1 inhibitor-associated BP, with grade 3 severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lili Cheng, Qi Song, Mengke Liu, Yan Wang, Hongmei Yi, Ying Qian, Pengpeng Xu, Shu Cheng, Chaofu Wang, Li Wang, Weili Zhao
Summary: PBL is a rare and aggressive hematological malignancy that commonly occurs in immune incompetent patients, with no specific standard treatment currently available. In some cases, immune therapy may be a potential treatment option for PBL, providing new insights into its management.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hongsik Kim, Hana Kim, Minsang Lee, Minsuk Kwon, Jung Yong Hong, Jeeyun Lee, Ho Yeong Lim, Won Ki Kang, Seung Tae Kim
Summary: The study found that immune checkpoint inhibitors showed similar clinical benefits in patients with refractory advanced gastric cancer in both the third-line and fourth-line settings, suggesting it may be a reasonable treatment approach.
Article
Oncology
Julian A. Marin-Acevedo, Bethany M. Withycombe, Youngchul Kim, Andrew S. Brohl, Zeynep Eroglu, Joseph Markowitz, Ahmad A. Tarhini, Kenneth Y. Tsai, Nikhil I. Khushalani
Summary: Cetuximab is a viable treatment option for patients with advanced cutaneous squamous cell carcinoma who fail or are ineligible for immunotherapy. Immediate use of cetuximab following anti-PD1 therapy progression shows rapid and durable responses, which should be confirmed in larger, prospective studies. If validated, cetuximab could be considered as the preferred second-line therapy after the failure of ICI.
Article
Oncology
Panagiotis A. Konstantinopoulos, Jung-Min Lee, Bo Gao, Rowan Miller, Jung-Yun Lee, Nicoletta Colombo, Ignace Vergote, Kelly M. Credille, Suzanne R. Young, Samuel McNeely, Xuejing Aimee Wang, Aimee Bence Lin, Ronnie Shapira-Frommer
Summary: This study aimed to evaluate the efficacy and safety of using prexasertib, a CHK1 inhibitor, in treating high-grade serous ovarian cancer. The results showed that prexasertib demonstrated durable single agent activity to a certain extent and its effects were not influenced by clinical characteristics, BRCA status, or prior therapies, including PARPi. The study also emphasized the need for alternative biomarker approaches to identify responders.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Cell Biology
Syn Kok Yeo, Michael Haas, Kanakaraju Manupati, Mingang Hao, Fuchun Yang, Song Chen, Jun-Lin Guan
Summary: This study identified a novel sensitization strategy for breast cancer treatment by activating the TBK-IFN pathway. Disrupting the selective autophagy function was found to activate the AZI2-TBK1-IFN signaling pathway, making breast cancer more responsive to immunotherapy.
Article
Immunology
Mark W. D. Sweep, Martijn J. H. Tjan, Mark A. J. Gorris, Kalijn F. Bol, Harm Westdorp
Summary: A male patient with metastatic melanoma developed life-threatening colitis and duodenitis after receiving ipilimumab and nivolumab therapy. Despite unresponsiveness to three lines of immunosuppressive treatment, the patient showed significant recovery after being administered with tofacitinib, a JAK inhibitor. Cellular and transcriptional data revealed ongoing colitis with high expression of CD8 T cells and PD-L1, suggesting that tofacitinib could be a promising option for ipilimumab/nivolumab-induced colitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Yasuhito Kunogi, Keiichi Tominaga, Keiichiro Abe, Mimari Kanazawa, Takanao Tanaka, Shoko Watanabe, Masayuki Kondo, Akira Kanamori, Makoto Iijima, Kenichi Goda, Yumi Nozawa, Kazuyuki Ishida, Atsushi Irisawa
Summary: ICIs can lead to gastrointestinal adverse effects, which should be managed promptly. In refractory cases where remission is hard to achieve, tacrolimus may be considered as an option.
Article
Immunology
Victor Cervera-Carrascon, Dafne C. A. Quixabeira, Joao M. Santos, Riikka Havunen, Ioanna Milenova, Jan Verhoeff, Camilla Heinio, Sadia Zafar, Juan J. Garcia-Vallejo, Victor W. van Beusechem, Tanja D. de Gruijl, Aino Kalervo, Suvi Sorsa, Anna Kanerva, Akseli Hemminki
Summary: Immune checkpoint inhibitors have revolutionized oncology, but most patients do not benefit from them. Using virotherapy to enhance T-cell activity could improve the efficacy of immune checkpoint inhibitors, even in resistant tumors. The combination of virotherapy with anti-PD-1 therapy led to increased survival in resistant tumors, showing promise in overcoming resistance to immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Edmond Ang, Angela Mweempwa, Campbell Heron, Yeri Ahn, Gareth Rivalland, Leah Y. Ha, Sanjeev Deva
Summary: Checkpoint inhibitor-associated myocarditis and myositis may occur concurrently, and cardiac-specific troponin I may be a more appropriate biomarker for diagnosing and monitoring myocarditis in the context of concurrent myositis.
JOURNAL OF IMMUNOTHERAPY
(2021)
Article
Hematology
Courtney D. DiNardo, Sangeetha Venugopal, Curtis Lachowiez, Koichi Takahashi, Sanam Loghavi, Guillermo Montalban-Bravo, Xuemei Wang, Hetty Carraway, Mikkael Sekeres, Ameenah Sukkur, Danielle Hammond, Kelly Chien, Abhishek Maiti, Lucia Masarova, Koji Sasaki, Yesid Alvarado, Tapan Kadia, Nicholas J. Short, Naval Daver, Gautam Borthakur, Farhad Ravandi, Hagop M. Kantarjian, Bhumika Patel, Amy Dezern, Gail Roboz, Guillermo Garcia-Manero
Summary: The combination of enasidenib with azacitidine showed a 74% overall response rate in newly diagnosed mIDH2 MDS patients, while enasidenib monotherapy achieved a 35% response rate in patients after HMA failure. These findings demonstrate that enasidenib is an effective treatment option for mIDH2 MDS.
Meeting Abstract
Hematology
Jaymeson Gordon, Christopher Haddad, Ishani Nautiyal, Yasuo Kubota, Hetty E. Carraway, Sudipto Mukherjee, Aaron T. Gerds, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Carmelo Gurnari, Valeria Visconte
Letter
Hematology
Tariq Kewan, Waled Bahaj, Arda Durmaz, Mai Aly, Olisaemeka D. Ogbue, Hetty E. Carraway, Mikkael A. Sekeres, Valeria Visconte, Carmelo Gurnari, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Eric Padron, Sara M. Tinsley-Vance, Amy E. DeZern, Hetty E. Carraway, Marlise R. Luskin, Gail J. Roboz, Onyee Chan, Meagan Horton, Aaron T. Gerds, David A. Sallman, Andrew Kuykendall, David Steensma, Maria E. Balasis, Jeffrey E. Lancet, Mikkael A. Sekeres, Rami S. Komrokji
Meeting Abstract
Hematology
Tariq Kewan, Waled Bahaj, Mai Aly, Arda Durmaz, Olisaemeka Ogbue, Hetty E. Carraway, Abhay Singh Singh, Suresh Kumar Balasubramanian, Mikkael A. Sekeres, Valeria Visconte, Carmelo Gurnari, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Fauzia Ullah, Danai Dima, Carmelo Gurnari, Suresh Kumar Balasubramanian, Olisaemeka Ogbue, Hussein Awada, Naomi Kawashima, Najiullah Omar, Swapna Thota, Hetty E. Carraway, Valeria Visconte, Jaroslaw P. Maciejewski
Meeting Abstract
Hematology
Nicholas Short, Tae Kon Kim, Rustin Lovewell, Elizabeth A. Griffiths, Hetty E. Carraway, Stephanie Zeidan, Elizabeth Knowles, Megan Nelson, Jahangheer Shaik, Chelsea Zhou, Emilia Alina Barbu, Zachary Cusumano, Subhadip Kundu, Sasan Sharee, Ron Copeland, Dallas Flies, Solomon Langermann, Han Myint, Jessica K. Altman, Farhad Ravandi
Article
Hematology
Amer M. Zeidan, Uwe Platzbecker, Jan Philipp Bewersdorf, Maximilian Stahl, Lionel Ades, Uma Borate, David Bowen, Rena Buckstein, Andrew Brunner, Hetty E. Carraway, Naval Daver, Maria Diez-Campelo, Theo de Witte, Amy E. DeZern, Fabio Efficace, Guillermo Garcia-Manero, Jacqueline S. Garcia, Ulrich Germing, Aristoteles Giagounidis, Elizabeth A. Griffiths, Robert P. Hasserjian, Eva Hellstrom-Lindberg, Marcelo Iastrebner, Rami Komrokji, Austin G. Kulasekararaj, Luca Malcovati, Yasushi Miyazaki, Olatoyosi Odenike, Valeria Santini, Guillermo Sanz, Phillip Scheinberg, Reinhard Stauder, Arjan A. van de Loosdrecht, Andrew H. Wei, Mikkael A. Sekeres, Pierre Fenaux
Summary: The initial response criteria developed by the International Working Group (IWG) in 2000 have limitations in their application to higher-risk MDS and their ability to fully capture the clinical benefits of novel investigational drugs. Therefore, an international panel of MDS experts used a modified Delphi process to develop consensus recommendations for updated response criteria that would be more reflective of patient-centered and clinically relevant outcomes. The updated criteria should lead to a better correlation between patient-centered outcomes and clinical trial results.
Meeting Abstract
Hematology
Julia H. Joo, Yanwen Chen, Aaron T. Gerds, Anjali Advani, Sophia R. Balderman, Hetty E. Carraway, Abhay Singh Singh, Sudipto Mukherjee
Meeting Abstract
Hematology
Tariq Kewan, Arda Durmaz, Waled Bahaj, Carmelo Gurnari, Hussein Awada, Olisaemeka Ogbue, Ramsha Ahmed, Simona Pagliuca, Hassan Awada, Yasuo Kubota, Minako Mori, Ben Ponvilawan, Bayan Al-Share, Bhumika J. Patel, Hetty E. Carraway, Jacob Scott, Suresh Kumar Balasubramanian, Taha Bat, Yazan F. Madanat, Mikkael A. Sekeres, Torsten Haferlach, Valeria Visconte, Jaroslaw P. Maciejewski
Meeting Abstract
Oncology
Sudipto Mukherjee, Weichuan Dong, Aaron T. Gerds, Hetty E. Carraway, Abhay Singh, Anjali S. Advani, Siran M. Koroukian
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Farhad Ravandi-Kashani, Ashwin Kishtagari, Hetty Carraway, Emily Curran, Gary Schiller, Alex Cacovean, Bhagyashree Yadav, Thomas Butler, Jeffrey Lancet
Meeting Abstract
Oncology
Farhad Ravandi, Hetty Carraway, Jack Khouri, Ashwin Kishtagari, Emily Curran, Gary Schiller, Bhagyashree (Kelshikar) Yadav, Steve Morris, Alex Cacovean, Sanchita Mourya, Thomas Butler, Jeffrey Lancet
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Meeting Abstract
Oncology
Farhad Ravandi, Ashwin Kishtagari, Hetty E. Carraway, Gary J. Schiller, Steve Morris, Alexandru Cacovean, Bhagyashree Kelshikar Yadav, Thomas Butler, Jeffrey E. Lancet
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Farhad Ravandi, Hetty E. Carraway, Lilia Taningco, Eric Laille, Jing Gong, Thomas Prebet, Daniel Lopes De Menezes, Andrew H. Wei
JOURNAL OF CLINICAL ONCOLOGY
(2022)