ESKAPEing the labyrinth of antibacterial discovery

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

(2015) Vincent M. Isabella et al.   CHEMISTRY & BIOLOGY

Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

(2015) Asha S. Nayar et al.   JOURNAL OF BACTERIOLOGY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

(2014) Tony D. Davis et al.   ACS Chemical Biology

The evolution of the regulatory framework for antibacterial agents

(2014) John H. Rex et al.   Annals of the New York Academy of Sciences

Pseudomonas aeruginosa Ceftolozane-Tazobactam Resistance Development Requires Multiple Mutations Leading to Overexpression and Structural Modification of AmpC

(2014) Gabriel Cabot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Systems Biology Analysis To Study the Mode of Action of the Isothiocyanate Compound Iberin on Pseudomonas aeruginosa

(2014) Sean Yang-Yi Tan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global transcriptional response of Acinetobacter baumannii to a subinhibitory concentration of tigecycline

(2014) Xiaoting Hua et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug development: Time for teamwork

(2014) Mike May   NATURE

Genome-Wide Identification of Acinetobacter baumannii Genes Necessary for Persistence in the Lung

(2014) N. Wang et al.   mBio

Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies

(2014) M. D. Valentino et al.   mBio

Genome-Wide Mutant Fitness Profiling Identifies Nutritional Requirements for Optimal Growth of Yersinia pestis in Deep Tissue

(2014) S. G. Palace et al.   mBio

Genome-Wide Saturation Mutagenesis of Burkholderia pseudomallei K96243 Predicts Essential Genes and Novel Targets for Antimicrobial Development

(2014) M. G. Moule et al.   mBio

Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection

(2014) Keith H. Turner et al.   PLoS Genetics

ChIP-Seq and RNA-Seq Reveal an AmrZ-Mediated Mechanism for Cyclic di-GMP Synthesis and Biofilm Development by Pseudomonas aeruginosa

(2014) Christopher J. Jones et al.   PLoS Pathogens

Siderophore conjugates

(2013) Malcolm G. P. Page   Annals of the New York Academy of Sciences

Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa

(2013) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

(2013) Boudewijn L. M. de Jonge et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

(2013) Vincent Hernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New natural products as new leads for antibacterial drug discovery

(2013) Dean G. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines

(2013) Maria Uria-Nickelsen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Toward Understanding the Outer Membrane Uptake of Small Molecules byPseudomonas aeruginosa

(2013) Elif Eren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC–MS based assay to measure intracellular compound levels in Mycobacterium smegmatis : Linking compound levels to cellular potency

(2013) Jyothi Bhat et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing

(2013) D. Skurnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a cation transport pathway inNeisseria meningitidisPorB

(2013) Christof Kattner et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection

(2013) Sargurunathan Subashchandrabose et al.   PLoS Pathogens

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

(2012) Thomas A. Keating et al.   ACS Chemical Biology

Progress toward single cell metabolomics

(2012) Stanislav S Rubakhin et al.   CURRENT OPINION IN BIOTECHNOLOGY

Microbiology and proteomics, getting the best of both worlds!

(2012) Jean Armengaud   ENVIRONMENTAL MICROBIOLOGY

A kinetic Monte Carlo approach to investigate antibiotic translocation through bacterial porins

(2012) Matteo Ceccarelli et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A metabolic network approach for the identification and prioritization of antimicrobial drug targets

(2012) Arvind K. Chavali et al.   TRENDS IN MICROBIOLOGY

Substrate Specificity within a Family of Outer Membrane Carboxylate Channels

(2012) Elif Eren et al.   PLOS BIOLOGY

In VitroandIn VivoProperties of BAL30376, a β-Lactam and Dual β-Lactamase Inhibitor Combination with Enhanced Activity against Gram-Negative Bacilli That Express Multiple β-Lactamases

(2011) Malcolm G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroValidation of Acetyltransferase Activity of GlmU as an Antibacterial Target inHaemophilus influenzae

(2011) Ed T. Buurman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bugs, drugs and chemical genomics

(2011) Terry Roemer et al.   Nature Chemical Biology

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

Genome-Scale Identification of Resistance Functions in Pseudomonas aeruginosa Using Tn-seq

(2011) L. A. Gallagher et al.   mBio

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial EfficacyIn Vivo

(2010) Scott D. Mills et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Atomic-Level Characterization of the Structural Dynamics of Proteins

(2010) D. E. Shaw et al.   SCIENCE

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Siderophores as drug delivery agents: application of the “Trojan Horse” strategy

(2009) Ute Möllmann et al.   BIOMETALS

Aligning Antimicrobial Drug Discovery with Complex and Redundant Host-Pathogen Interactions

(2009) Sarah L. Lebeis et al.   Cell Host & Microbe

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY