Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

(2012) Thomas A. Keating et al.   ACS Chemical Biology

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Perpetual Challenge of Infectious Diseases

(2012) Anthony S. Fauci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyrrolamide DNA gyrase inhibitors: Optimization of antibacterial activity and efficacy

(2011) Brian A. Sherer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Does broad-spectrum  -lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria?

(2011) P. Nordmann et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine

(2011) Hye-Jin Yoon et al.   MOLECULES AND CELLS

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial EfficacyIn Vivo

(2010) Scott D. Mills et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Use of Biochemical and Biophysical Tools for Triage of High-Throughput Screening Hits - A Case Study with Escherichia coli Phosphopantetheine Adenylyltransferase

(2010) J. Richard Miller et al.   Chemical Biology & Drug Design

Hospital and Societal Costs of Antimicrobial‐Resistant Infections in a Chicago Teaching Hospital: Implications for Antibiotic Stewardship

(2009) Rebecca R. Roberts et al.   CLINICAL INFECTIOUS DISEASES

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

New concepts in antimicrobial susceptibility testing: the mutant prevention concentration and mutant selection window approach

(2009) Joseph M. Blondeau   VETERINARY DERMATOLOGY