The interplay between Siglecs and sialylated pathogens

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

(2013) Takashi Angata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus

(2013) R. S. Prather et al.   JOURNAL OF VIROLOGY

Interferon-Inducible Mechanism of Dendritic Cell-Mediated HIV-1 Dissemination Is Dependent on Siglec-1/CD169

(2013) Wendy Blay Puryear et al.   PLoS Pathogens

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Sialoadhesin Promotes Rapid Proinflammatory and Type I IFN Responses to a Sialylated Pathogen, Campylobacter jejuni

(2012) M. Klaas et al.   JOURNAL OF IMMUNOLOGY

Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

(2012) B. Khatua et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells

(2012) W. B. Puryear et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Campylobacter jejuni Lipooligosaccharides Modulate Dendritic Cell-Mediated T Cell Polarization in a Sialic Acid Linkage-Dependent Manner

(2011) Marieke Bax et al.   INFECTION AND IMMUNITY

Human Siglec-5 Inhibitory Receptor and Immunoglobulin A (IgA) Have Separate Binding Sites in Streptococcal β Protein

(2011) Therése Nordström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Bacterial Meningitis in the United States, 1998–2007

(2011) Michael C. Thigpen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Siglecs Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids

(2011) Zhongcheng Zou et al.   PLoS One

O-Acetylation of sialic acid on Group BStreptococcusinhibits neutrophil suppression and virulence

(2010) Shannon Weiman et al.   BIOCHEMICAL JOURNAL

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

(2010) Huan Cao et al.   IMMUNOLOGY

Characterization of the Specific Interaction between Sialoadhesin and Sialylated Campylobacter jejuni Lipooligosaccharides

(2010) A. P. Heikema et al.   INFECTION AND IMMUNITY

TLR4-Mediated Sensing of Campylobacter jejuni by Dendritic Cells Is Determined by Sialylation

(2010) M. L. Kuijf et al.   JOURNAL OF IMMUNOLOGY

Pseudomonas aeruginosa: Host defence in lung diseases

(2010) Bryan J. WILLIAMS et al.   RESPIROLOGY

The M/GP5 Glycoprotein Complex of Porcine Reproductive and Respiratory Syndrome Virus Binds the Sialoadhesin Receptor in a Sialic Acid-Dependent Manner

(2010) Wander Van Breedam et al.   PLoS Pathogens

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Sialylated ligands on pathogenicTrypanosoma cruziinteract with Siglec-E (sialic acid-binding Ig-like lectin-E)

(2009) Hanna Erdmann et al.   CELLULAR MICROBIOLOGY

Sialic acids acquired byPseudomonas aeruginosaare involved in reduced complement deposition and siglec mediated host-cell recognition

(2009) Biswajit Khatua et al.   FEBS LETTERS

Genetic and biochemical modulation of sialic acid O-acetylation on group B Streptococcus: Phenotypic and functional impact

(2009) S. Weiman et al.   GLYCOBIOLOGY

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression

(2009) Chuan Wu et al.   JOURNAL OF IMMUNOLOGY

Sialoadhesin Expressed on IFN-Induced Monocytes Binds HIV-1 and Enhances Infectivity

(2008) Hans Rempel et al.   PLoS One