Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Modeling Sporadic Alzheimer's Disease: The Insulin Resistant Brain State Generates Multiple Long-Term Morphobiological Abnormalities Including Hyperphosphorylated Tau Protein and Amyloid-β

(2017) Melita Salkovic-Petrisic et al.   JOURNAL OF ALZHEIMERS DISEASE

The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease

(2014) Konrad Talbot et al.   Alzheimers & Dementia

Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies

(2014) Alexei Verkhratsky et al.   CELL CALCIUM

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

A Single-Dose Pilot Trial of Intranasal Rapid-Acting Insulin in Apolipoprotein E4 Carriers with Mild–Moderate Alzheimer’s Disease

(2014) Michael H. Rosenbloom et al.   CNS DRUGS

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

(2014) M. Heni et al.   DIABETES

Cortisol, but not intranasal insulin, affects the central processing of visual food cues

(2014) Diana S. Ferreira de Sá et al.   PSYCHONEUROENDOCRINOLOGY

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes

(2013) Vera Novak et al.   DIABETES CARE

Hippocampal calcium dysregulation at the nexus of diabetes and brain aging

(2013) Olivier Thibault et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats

(2013) Tristano Pancani et al.   NEUROBIOLOGY OF AGING

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

(2012) F. Deak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Intranasal Insulin Modulates Intrinsic Reward and Prefrontal Circuitry of the Human Brain in Lean Women

(2012) Stephanie Kullmann et al.   NEUROENDOCRINOLOGY

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes

(2011) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Insulin Reduces Neuronal Excitability by Turning on GABAA Channels that Generate Tonic Current

(2011) Zhe Jin et al.   PLoS One

Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

(2010) C. Benedict et al.   DIABETES

Nasal absorption of mixtures of fast-acting and long-acting insulins

(2010) Dennis J. Pillion et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Aging-Related Gene Expression in Hippocampus Proper Compared with Dentate Gyrus Is Selectively Associated with Metabolic Syndrome Variables in Rhesus Monkeys

(2010) E. M. Blalock et al.   JOURNAL OF NEUROSCIENCE

Insulin receptor signaling in the development of neuronal structure and function

(2010) Shu-Ling Chiu et al.   Neural Development

Effects of Long-Term Pioglitazone Treatment on Peripheral and Central Markers of Aging

(2010) Eric M. Blalock et al.   PLoS One

Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors

(2009) D. R. Marks et al.   JOURNAL OF NEUROSCIENCE

Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors via Protein Kinase B/Akt Phosphorylation of NR2C

(2009) Bo-Shiun Chen et al.   NEURON

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin

(2008) Christian Benedict et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

(2008) Alexis M Stranahan et al.   NATURE NEUROSCIENCE

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL