The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo

The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule

(2017) Izumi Maezawa et al.   JOURNAL OF ALZHEIMERS DISEASE

A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

(2017) Srikant Rangaraju et al.   Journal of Neuroinflammation

T-type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular-spiking oriens-alveus interneurons

(2017) Elizabeth Nicholson et al.   JOURNAL OF PHYSIOLOGY-LONDON

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Location, Location, Location: Microglia Are Where They Live

(2017) Margaret M. McCarthy   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Quantification of the functional expression of the Ca2+-activated K+channel KCa3.1 on microglia from adult human neocortical tissue

(2016) Linda V. Blomster et al.   GLIA

Differential Kv1.3, KCa3.1, and Kir2.1 expression in “classically” and “alternatively” activated microglia

(2016) Hai M. Nguyen et al.   GLIA

The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke

(2016) Yi-Je Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain trauma elicits non-canonical macrophage activation states

(2016) Charles C. Kim et al.   Journal of Neuroinflammation

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

(2015) Marina A Lynch   BRAIN RESEARCH

Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: A Mechanism for Mitochondrial Dysfunction and Neurotoxicity

(2015) L.-W. Jin et al.   JOURNAL OF NEUROSCIENCE

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Expression and contributions of the Kir2.1 inward-rectifier K+ channel to proliferation, migration and chemotaxis of microglia in unstimulated and anti-inflammatory states

(2015) Doris Lam et al.   Frontiers in Cellular Neuroscience

Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice

(2015) Nicoletta Charolidi et al.   PLoS One

Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis – Xenograft model

(2014) Smriti Kundu-Raychaudhuri et al.   JOURNAL OF AUTOIMMUNITY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Erratum: Corrigendum: Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2014) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory “Barrel” cortex

(2013) Isabelle Arnoux et al.   GLIA

Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

(2013) Ying Peng et al.   NEURO-ONCOLOGY

Kv1.3 Deletion Biases T Cells toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis

(2012) A. R. Gocke et al.   JOURNAL OF IMMUNOLOGY

Long Term Potentiation Is Impaired in Membrane Glycoprotein CD200-deficient Mice

(2011) Derek A. Costello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia

(2011) Tom Schilling et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons

(2010) Valeswara-Rao Gazula et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Ca2+ activated SK3 channel is expressed in microglia in the rat striatum and contributes to microglia-mediated neurotoxicity in vitro

(2010) Lyanne C Schlichter et al.   Journal of Neuroinflammation

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

(2008) Anthony J. Harmar et al.   NUCLEIC ACIDS RESEARCH