Neuronal extracellular vesicle derived miR-98 prevents salvageable neurons from microglial phagocytosis in acute ischemic stroke

RNA N6-methyladenosine modification is required for miR-98/MYCN axis-mediated inhibition of neuroblastoma progression

(2020) Junmei Cheng et al.   Scientific Reports

Stroke management — recent advances and residual challenges

(2019) Bo Norrving   Nature Reviews Neurology

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

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Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke

(2019) Jianpei Xu et al.   ACS Nano

miR-98 reduces endothelial dysfunction by protecting blood–brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model

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Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

(2019) Yuqin Men et al.   Nature Communications

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury

(2018) Geoffrey T. Norris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia

(2018) Schuichi Koizumi et al.   NEUROCHEMISTRY INTERNATIONAL

Impact of microRNAs on ischemic stroke: From pre- to post-disease

(2018) Guangwen Li et al.   PROGRESS IN NEUROBIOLOGY

Exosome Therapy for Stroke

(2018) Jieli Chen et al.   STROKE

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

(2018) Amaia Otxoa-de-Amezaga et al.   ACTA NEUROPATHOLOGICA

Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery

(2018) Minako Ito et al.   NATURE

A novel cell-cell communication mechanism in the nervous system: exosomes

(2017) Guan Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors

(2017) Jenni E. Anttila et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery

(2017) Changhong Xing et al.   PROGRESS IN NEUROBIOLOGY

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

(2017) Raffaele Simeoli et al.   Nature Communications

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases

(2016) Anna M. Janas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Exosomes in stroke pathogenesis and therapy

(2016) Zheng Gang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

MiR-132 Is Upregulated by Ischemic Preconditioning of Cultured Hippocampal Neurons and Protects them from Subsequent OGD Toxicity

(2016) Matthew P . Keasey et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

miR-98-5p Acts as a Target for Alzheimer’s Disease by Regulating Aβ Production Through Modulating SNX6 Expression

(2016) Qiushi Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation

(2016) Yin-Feng Dong et al.   Journal of Neuroinflammation

Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis

(2016) M. J. Bellizzi et al.   JOURNAL OF NEUROSCIENCE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Exosomes as a potential novel therapeutic tools against neurodegenerative diseases

(2016) Akvilė Jarmalavičiūtė et al.   PHARMACOLOGICAL RESEARCH

MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

(2015) Jingshu Ni et al.   BRAIN BEHAVIOR AND IMMUNITY

miR-98 and let-7g* Protect the Blood-Brain Barrier Under Neuroinflammatory Conditions

(2015) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

The poly-γ- d -glutamic acid capsule surrogate of the Bacillus anthracis capsule induces nitric oxide production via the platelet activating factor receptor signaling pathway

(2015) Hae-Ri Lee et al.   MOLECULAR IMMUNOLOGY

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons

(2014) Belinda J. Goldie et al.   NUCLEIC ACIDS RESEARCH

Exosomes

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Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of Apoptotic Cells by Macrophages Induces Regulatory Phenotype and Involves Stimulation of CD36 and Platelet-Activating Factor Receptor

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Phagocytosis executes delayed neuronal death after focal brain ischemia

(2013) J. J. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Exosomes are endogenous nanoparticles that can deliver biological information between cells

(2012) Dongmei Sun et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

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Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges

(2011) J. S. McDonald et al.   CLINICAL CHEMISTRY

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

(2011) J. J. Neher et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

(2010) Guy C. Brown et al.   MOLECULAR NEUROBIOLOGY

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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