Review
Oncology
Xue-Jiao Lu, Lin Li, Xin-Ying Zhou
Summary: This meta-analysis found a significant association between CCR2-V64I polymorphism and cancer risk, particularly among Asians, with a higher risk observed for bladder and oral cancers.
EUROPEAN JOURNAL OF CANCER CARE
(2023)
Article
Neurosciences
Lifei Xu, Qiuping Dong, Liben Xu, Wei Zou, Hui Li
Summary: The study found that the MCP-1 A-2518 G polymorphism is associated with an increased risk of Alzheimer's disease (AD) and higher serum MCP-1 levels in AD patients. The GG genotype was shown to elevate the risk of AD, especially in males, smokers, APOEε4+ carriers, and individuals aged 65 and older. Additionally, there was an interaction between the MCP-1 A-2518 G polymorphism and smoking that contributed to the increased risk of AD in Chinese individuals.
NEUROSCIENCE LETTERS
(2021)
Article
Pathology
Nihal Salah Ibrahim, Manal Mohamed Makhlouf, Gehan Hamed Shahin, Mona Kamal Elghamrawy, Nehad Mohammed Hussein
Summary: This study aimed to explore the frequency and possible effect of MCP1-2518A/G and CCR2-V64I genetic polymorphisms on clinical and laboratory variables in Egyptian Sickle cell disease patients. The study revealed that CCR2-V64I genetic polymorphism was significantly associated with SCD patients compared to the control subjects. The polymorphic genotypes were also found to influence the clinical severity of sickle cell disease.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Cell Biology
Sang-Ah Lee, Deokhwan Kim, Chanhyuk Min, Byeongjin Moon, Juyeon Lee, Hyunji Moon, Susumin Yang, Chang Sup Lee, Gwangrog Lee, Daeho Park
Summary: In this study, it was found that phagocytes are recruited to apoptotic cells being cleared through the Mcp-1-Ccr2 axis, facilitating the clearance of apoptotic cells. Increased secretion of Mcp-1 by phagocytes engulfing apoptotic cells promotes cell migration, while blockade of Ccr2 reduces cell migration to conditioned medium from phagocytes incubated with apoptotic cells.
Article
Endocrinology & Metabolism
Francesca Coperchini, Alessia Greco, Laura Croce, Elena Petrosino, Beatrice Grillini, Flavia Magri, Luca Chiovato, Mario Rotondi
Summary: Vitamin D treatment reduces cell migration and inhibits the secretion of CCL2 and CXCL8 in thyroid cancer cells. This study reveals the significant role of vitamin D in thyroid cancer progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Qiu Du, Ying-xue Fu, An-mei Shu, Xing Lv, Yu-ping Chen, Yu-yan Gao, Jing Chen, Wei Wang, Gao-hong Lv, Jin-fu Lu, Hui-qin Xu
Summary: Loganin protects the kidney from damage in diabetic nephropathy by inhibiting macrophage infiltration and activation. It regulates the RAGE/MCP-1/CCR2 signaling pathway, affecting macrophage phenotypic transformation and expression of inflammatory factors.
Review
Biochemistry & Molecular Biology
Suguru Kadomoto, Kouji Izumi, Atsushi Mizokami
Summary: Chemokines are a family of cytokines that play important roles in cancer progression. The CCL2-CCR2 axis is a major chemokine signaling pathway that impacts tumor progression significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Niki Ghambari Mohammadi, Saeed Namaki, Seyed Mahmoud Hashemi, Mohammadreza Salehi, Sara Ghaffarpour, Tooba Ghazanfari
Summary: This study aimed to assess the relationship between MCP-1 G-2518A and serum MCP-1 levels in Iranian COVID-19 patients and the severity of the disease. The study found that COVID-19 patients had significantly elevated serum levels of MCP-1, which was associated with hospitalization and disease severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hee-Kyung Park, Yun Hee Na, Huong Thi Nguyen, Lan Phuong Nguyen, Sunghoon Hurh, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Summary: CCR2A and CCR2B have different characteristics in terms of cell surface localization and internalization due to their different C-terminal intracellular loops. CCR2A has a stronger response to MCP-1 stimulation and may play an important role in solid cancer progression.
CELL AND BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Liang Ding, Wenjing Zhou, Jian Zhang, Qingsong Tang, Weizhang Xiao, Ming Chen, Zhenya Shen, Weiqian Chen
Summary: Uncontrolled inflammation can cause sepsis-associated immune disorders, and EVs can be used as drug carriers to target inflammatory monocytes for treatment, showing potential clinical significance.
Article
Immunology
Wei Wang, Jianzhong Ai, Banghua Liao, Kaiwen Xiao, Lede Lin, Huiling Chen, Liang Zhou
Summary: The study demonstrates that M1 macrophages are predominantly observed at the inflammatory stage while M2 macrophages are mainly found during the fibrosis stage in bladder outlet obstruction. Furthermore, M2 macrophages promote BOO-induced fibrosis through the secretion of TGF-beta and transformation into collagen-producing myofibroblasts. Targeting the MCP-1/CCR2 signaling pathway may be a potential therapeutic strategy for bladder fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Virology
Xueyan Xi, Yang Guo, Min Zhu, Yuhui Wei, Gang Li, Boyu Du, Yunfu Wang
Summary: The levels of chemokines, particularly monocyte chemotactic protein 1 (MCP-1), are elevated in mild COVID-19 patients in Shiyan City, China. The high expression of MCP-1 in mild cases may be correlated with inhibition of interferon signaling, providing potential therapeutic targets.
Article
Oncology
Xuancheng Ou, Tianyong Wen, Jinwei Ying, Qing He, Anwu Xuan, Dike Ruan
Summary: The study observed significant upregulation of MCP-1 in NPSCs cultured in vitro, which inhibited migration, proliferation, and chondrogenic differentiation of NPSCs. MCP-1 exerted its effects by enhancing CCR2 expression, and the effects could be reversed by blocking CCR2 with an inhibitor.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Immunology
Li Zhang, Wenrui Xie, Jingdong Zhang, Hailey Shanahan, Raquel Tonello, Sang Hoon Lee, Judith A. Strong, Temugin Berta, Jun -Ming Zhang
Summary: Chronic low back pain is a common condition with high societal costs and often ineffective treatments. This study found that the CCR2/CCL2 system plays a key role in establishing the pain state in this model of inflammatory low back pain and radiculopathy, with different subsets of macrophages potentially influencing the pain state.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Qun Lu, Haoli Yin, Yongming Deng, Wei Chen, Wenli Diao, Meng Ding, Wenmin Cao, Yao Fu, Wenjing Mo, Xiaoqing Chen, Qing Zhang, Xiaozhi Zhao, Hongqian Guo
Summary: This study reveals the regulatory mechanism of circDHTKD1 in lymphangiogenesis and lymph node metastasis in bladder cancer. By interacting with miR-149-5p and regulating CXCL5 expression, circDHTKD1 promotes lymphangiogenesis and recruits and activates neutrophils, contributing to lymph node metastasis in bladder cancer.
CELL DEATH DISCOVERY
(2022)
Article
Psychiatry
Hatice Humeyra Yavuz Gokce, Selcuk Dasdemir, Cem Ismail Kucukali, Elif Sinem Iplik, Bedia Cakmakoglu
ARCHIVES OF CLINICAL PSYCHIATRY
(2020)
Article
Immunology
B. Aydin Ozgur, E. Coskunpinar, S. Bilgic Gazioglu, A. Yilmaz, Y. Musteri Oltulu, B. Cakmakoglu, G. Deniz, A. O. Gurol, M. T. Yilmaz
Summary: The study suggests that protein levels of CD55 and CD59, as well as polymorphisms in SDF-1 and CXCR-4, may play a predictive role in the progression, complications, and susceptibility of type 2 diabetes mellitus (T2DM). Variations in the expression of these genes and proteins were found to be associated with nephropathy, retinopathy, and cardiovascular diseases related to T2DM.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Medicine, Research & Experimental
Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu
Summary: The study found that succinic acid has apoptotic effects on T-ALL cell lines without significant cytotoxic effects on healthy cells. The apoptotic activity of succinic acid on CCRF-CEM cell line is caspase-3 dependent, while it is not for MOLT-4 cell line.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Oncology
Levent Aydemir, Elif Sinem Iplik, Baris Ertugrul, Goksu Kasarci, Merve Nur Atas, Murat Ulusan, Arzu Ergen, Bedia Cakmakoglu
Summary: The study investigated the anti-proliferative and apoptotic effects of the levofloxacin-cisplatin combination in oral squamous cell carcinoma cells. It was found that the combination had a more effective impact on SCC-15 cells compared to single cisplatin treatment, while showing lower toxicity to healthy cells.
Article
Dentistry, Oral Surgery & Medicine
Ozgur Ozturk, Bedia Cakmakoglu, Gizem Nur Ozturk, Meral Unur
Summary: This study investigated the frequency of MCP-1 CCR2 gene polymorphisms in patients with OLP and control participants, finding differences in certain genotypes but no statistically significant results.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Oncology
Goksu Kasarci, Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu
Summary: Studies have demonstrated that succinic acid exhibits significant cytotoxic and apoptotic activity on renal cancer cells, while having no significant impact on healthy cells. This suggests that succinic acid could be a potential therapeutic agent for individualized cancer treatment approaches, warranting further molecular research.
Article
Medicine, General & Internal
Bedia cakmakoglu
Summary: This study investigated the relationship between the genetic polymorphism of MMP9(rs17576) and TIMP1(rs48498) and serum levels, as well as the effect of MMP9 and TIMP1 genotypes on Vitamin D serum levels in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with and without Aspirin-Exacerbated Respiratory Disease (AERD).
JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
(2023)
Article
Environmental Sciences
Baris Ertugrul, Amal Mohammed, Goksu Kasarci, Sinem Bireller, Murat Ulusan, Bedia Cakmakoglu
Summary: This study aimed to investigate the impact of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) gene polymorphisms on oral squamous cell carcinoma (OSCC) patients and non-OSCC healthy controls. Using polymerase chain reaction (PCR) and restriction fragment length polymorphism methods, a case-control study was conducted on 89 OSCC patients and 107 healthy controls, analyzing the genotypes for EGF + 61 A > G (rs4444903) and EGFR R497K (rs2227983). The results showed that the G allele of EGF + 61 A > G polymorphism was associated with OSCC, indicating the need for further investigation into the nature of the interaction between EGF and OSCC using larger populations and functional studies.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Medicine, General & Internal
Merve Nur Atas, Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu, Arzu Ergen
Summary: This study investigates the effects of betulinic acid on autophagy in renal cell carcinoma cells. The results suggest that betulinic acid can modulate autophagy in these cells. The effects of autophagy may vary depending on the origin of the cells and the concentration of betulinic acid used.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2023)
Article
Oncology
Merve Nur Atas, Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu, Arzu Ergen
Summary: Betulinic acid has potential anti-metastatic effects on renal cancer by targeting SNAIL-1 and SDC-2, leading to the suppression of cell migration and invasion.
Article
Urology & Nephrology
Merve Nur Atas, Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu, Arzu Ergen
Summary: This study demonstrates the apoptotic effect of betulinic acid on renal cancer cells and its non-toxic effect on healthy cells. Gene expression analysis reveals a significant decrease in AKT-1 expression level and an increase in mTOR expression level. Therefore, betulinic acid may be a potential anticancer drug worthy of further investigation.
TURKISH JOURNAL OF UROLOGY
(2022)
Article
Oncology
Beste Tacal Aslans, Baris Ertugrul, Elif Sinem Iplik, Bedia Cakmakoglu
Summary: The study demonstrated the anti-tumor and apoptosis-inducing effects of acacetin on colorectal cancer cell lines, with no lethal effect on healthy lung cells.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Surgery
Adem Akcakaya, Nurcan Unver, Tugba Aydogan Kiris, Mehmet Guzel, Fatma Betul Akcakaya, Bedia Cakmakoglu, Mustafa Hasbahceci
Summary: The study found that the -160 C -> A polymorphism may influence the expression of E-cadherin in gastric cancer, but it showed no significant difference in survival rates. There was no significant association between polymorphisms and E-cadherin expression in gastric cancer patients.
TURKISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Arzu Ergen, E. Sinem Iplik, Baris Ertugrul, Merve Nur Atas, Goksu Kasarci, Bedia Cakmakoglu
MARMARA MEDICAL JOURNAL
(2020)
Article
Medicine, Research & Experimental
Cagla Rencuzogullari, Zeynep Birsu Cincin, Elif Sinem Iplik, Yusuf Baran, Bedia Cakmakoglu
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2019)
